After graduating from West China Medical University in 2000, Zhou Xianxin was assigned to a pharmaceutical factory in Guangzhou, where she was the minister of arts and culture, and couldn't stand the dull atmosphere. It was at this time that Japan's Fuji Television held a beauty contest in Guangzhou, and she took the attitude of trying to participate in it, but she took home the trophy and went to Japan for cultural exchange. After returning to Guangzhou, Zhou Xianxin quit her job at the pharmaceutical company and began to concentrate on acting: she took on commercials, worked as a TV host, and so on, officially entering the acting world. In the same year, Zhou Xianxin was admitted to the acting department of the Central Academy of Drama as a publicly-funded graduate student.
In 2001, Zhou Xianxin became popular with the movie "Zhou Fisherman's Train"; in 2002, she played the lead role of Xu Wanyun in the TV series "Oath of Silence" (which won the first prize of the 23rd Golden Eagle Award and Feitian Award for long-running TV dramas), and the lead role of Meizuo in the movie "Copper Drum" (which won the "Best Ethnic Movie" award from the CCTV-6 Movie Channel). " award).
In 2003, she played the lead role of Liu Xiaoning in the movie "No Horizon in the City" (which won the "Top Ten Digital Movies" award at the China University Film Festival), and played the lead role of Su Qi in the TV series "Red Pink Family", which was adapted from author Zhang Henshui's novel "Man Jiang Hong" (满江红).
In 2004, she appeared in the TV drama "Love is Innocent" as the female lead Wu Yi Fan and the 30-episode TV series "Windy House" as the female lead Ru Yue.
In 2005, she starred in the movie "Monster" and played the role of Chen Li; in the same year, she played the role of Wu Yi Fan in the TV drama "Love is Innocent", and won the Outstanding Performer Award of the 16th TV "Peony Award" in Zhejiang Province for the drama; in the same year, she also starred in the movie "The Wizard of Fairy Girl"; in March 2006, she starred in the movie "Ghosts of Souls" as the female lead, Xiao Yu; in March 2006, she starred in the movie "Ghosts of Spirits" as the female lead, Xiao Yu. In March 2006, she appeared in the movie "Ghosts and Souls", playing the female lead role of Xiaoyu; in the same year, she also played the female lead role of Pan Zhuxiang in the TV drama "Escape from Shangri-La".
In 2007, she played the role of Dahong in the TV series "Misty Willow Town"; in 2008, she played the female lead role of Xiaoxiao in the movie "Little Li Guang Hua Rong"; and she also played the roles of Chen Xiaojun and Sunflower in the TV series "A Drop in the Ocean".
In 2009, Chen Qiong, the female lead in the movie "Gaokao 1977", won the 13th Huabiao Award for Outstanding Feature Film, and was nominated for Best Screenplay and Best Film at the 18th Golden Rooster Awards, as well as the Golden Angel Award at the Fifth China-US Film Festival. In the same year, she played the lead role of Tang Mengyun in China's first large-scale domestic detective mystery and deduction drama "Detective Story".
In 2010, she appeared in the movie "The River Chief" as the lead actress Cheng Chen, the TV series "Da Sheng Kui" as the lead actress Sun Xiangyu, and the play "The Unexpected Guest", which won a full house, and was very popular among Shanghai drama fans (the play toured Shanghai in 2012).
In 2011, she played the role of Qin Xiaoyang in the hit CCTV drama "Destiny of the Nation", a 29-episode documentary epic about the development of China's "Two Bombs and One Star", which was a hit; in the same year, she starred in the horror movie "Midnight Fierce Dreams" in the controversial role of Fang Lei; and she played the role of Ji Hao in the historical TV drama "Da Shun", in which she played the lead role of Sun Xiangyu. Ji Hao.
In March 2012, Zhou Xianxin disguised as a "Russian girl" in the Oriental Satellite TV "Dance Congress" to a song "Moscow Nights" challenge standard cha-cha-cha, and Zhou Xianxin performance of a small mistake also made her become the "most controversial" contestants, triggering the judges' opinions. In June of the same year, she was invited to be the female guest of "Thank God You're Here" and appeared in the Republic of China high-intelligence suspense action movie "National Treasure Doubt" as the female lead Xiang Yun. In September of the same year, she played the role of Shen Lan in the urban family comedy "Mother-in-Law's Happy Life".
In 2013, she played the lead role of Luo Tianqing in the financial espionage drama "The Golden War", Zhao Xiaofei in the TV drama "Marriage Time Difference", and the lead role of Liu Yue in the urban emotional comedy "Place Your Order for Happiness" in September of the same year.