Y, my two sisters both suffered from progressive muscular dystrophy when they were twenty years old, and it has been more than ten years now. My daughter, now 33 years old, neither my brother nor my p

Y, my two sisters both suffered from progressive muscular dystrophy when they were twenty years old, and it has been more than ten years now. My daughter, now 33 years old, neither my brother nor my parents have this disease. Both my sister and my father have them. ... There are many kinds of progressive muscular dystrophy, which may occur at all ages. If you say that your parents are not sick, they should carry genetic disease-causing genes (unless the previous generation had disease-causing genes). Your two sisters have the same blood type as your father, so your father is more likely to carry the disease-causing gene. In this case, your two sisters are either recessive or dominant. If a disease-causing gene comes from your father, your mother should.

The diagnosis is 1. Often have a family history. X chromosome 2. The diseased muscles first involved the proximal limb muscles, with pseudohypertrophy on both sides, weakness of lower limbs, gait swing and positive Goyle sign; It is difficult to lift the arm of the upper limb.

3. Normal skin perception, no tendon reflex and hyperreflexia, no muscle tremor.

4. The significant increase of blood CPK is the most sensitive index, which is helpful for early diagnosis; Alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase can be increased.

5. EMG is consistent with muscle thickness injury; Muscle biopsy revealed fibrosis; Dystrophin content determination and PCR technology are helpful for diagnosis.

I suggest you have a diagnosis once a year. It's hard to say when the pathogenic gene works, but the incidence of this disease is higher in men than in women, so your brother should be more dangerous than you. In fact, it is good to go to a big hospital for a chromosome examination.