What effect does low progesterone have on pregnant women and fetuses?

The content of progesterone in pregnant mothers is low, and progesterone is produced in the early pregnancy. The function of placenta in early pregnancy is not very good, and there will be low progesterone, and the baby is very prone to threatened abortion. If progesterone is particularly low, it is also prone to fetal abortion. If there is luteal insufficiency before pregnancy, progesterone test should be carried out early after pregnancy. Before threatened abortion, be sure to find out whether progesterone is normal or not, and make up if it is slightly lower. Especially on the premise that intrauterine pregnancy has been confirmed by B-ultrasound, progesterone or progesterone tablets should be supplemented as soon as possible to maintain a normal and relatively stable indoor environment of the uterus, which is conducive to the normal development of IVF.

The low level of progesterone is generally mainly caused by insufficient luteal function. Because lutein metabolism is insufficient after ovulation, estrogen secretion is reduced, and the metabolic transformation of uterine wall is insufficient, it is easy to cause dysfunctional uterine bleeding during ovulation, and sperm-egg combination is not easy for embryo implantation or infertility and recurrent abortion. The causes of luteal insufficiency are insufficient secretion of lutein and follicle stimulating hormone by pituitary gland, or excessive metabolism of prolactin. The specific clinical manifestations are menorrhagia, infertility and abortion, which can generally be distinguished by taking blood to detect estrogen during ovulation.

Progesterone can promote the growth and development of in vitro embryos and intrauterine babies. When progesterone is low, the growth of test-tube embryos will be affected, which will make the fetal development lower than normal and even lead to embryo abortion. Progesterone can not be used as the main index to distinguish the survival of embryos in vitro. However, if there are factors such as insufficient corpus luteum function, too low progesterone may lead to abortion, so it is necessary to protect the fetus as soon as possible. When progesterone is less than 5ng/ml, the effect of fetal protection treatment is not good. The fundamental reason is that progesterone can make the glandular ducts in the uterine mucosa grow and develop, and the uterine hematoma and endometrium thicken, so that the baby can grow and develop safely. When progesterone is too low, the uterine sarcoplasmic reticulum cannot be relaxed, and estrogen is not enough to soften the uterine wall, which is not conducive to embryo implantation and embryo development in vitro, so it may lead to threatened abortion.

Progesterone can reduce the body fluid regulation and sensitivity of uterus during pregnancy. If progesterone is slightly lower, it may not be able to inhibit the regulation of body fluids in the uterus, thus causing premature delivery and causing certain interference to the baby. Patients with threatened abortion and habitual abortion can take estrogen for protective abortion. Pregnant mothers need to pay attention to rest on time in daily life, prevent staying up late often, prevent excessive exercise, reasonably match their diet and ensure nutrition. You also need to maintain a stable mood at ordinary times and go to a big hospital for regular check-ups.