How big are the side effects of playing growth hormone?

The earliest auxin was extracted from the pituitary gland of a person who had just died (the first generation of auxin). Because different people die for different reasons, it is entirely possible to be infected with sexually transmitted diseases. Now auxin is the fifth generation, which is completely synthesized by genetic engineering in the factory and cannot cause infectious diseases. The other side effects you mentioned are all on the premise of overdose. Any drug overdose may lead to serious side effects. When we study pharmacology, the lethal dose of most drugs is half, that is, when that dose is reached, half of people will die. Using this amount to evaluate the safety of drugs, there will be no available drugs in the world. Under the normal therapeutic dose, these side effects you mentioned will hardly appear. Auxin was initially approved for auxin deficiency, and then used for small for gestational age infants, Turner syndrome and so on. Auxin has good safety. In 2003, the US Food and Drug Administration (FDA), the strictest institution in the world, officially approved auxin for the treatment of non-auxin deficiency. One must be safe and the other must be effective, and both are indispensable. In recent years, auxin has also been used to treat cardiovascular diseases, and it has been found to have a good therapeutic effect in the fields of weight loss and anti-aging. In recent years, there is evidence that auxin is beneficial to intellectual development. In the United States and Japan, auxin therapy for auxin deficiency has been included in the national health plan, and the European Endocrine Association officially announced in 1993 that recombinant human growth hormone (rhGH) is safe and effective in the treatment of short stature. If it is like what you said, why did the country approve the use? Why do doctors use auxin to treat people? The doctor will also consider the pros and cons for you when he treats you. If it is auxin deficiency, it is more appropriate to treat it with auxin. If that has side effects, won't normal people have side effects because of auxin? But auxin is a prescription drug, and no one can use it without any inspection. It can only be used after strict inspection. The application of auxin, like other drugs, can't be absolutely safe, just as you can't be absolutely sure that the plane won't fall on your head at home. The whole world knows that it is wrong to "give up eating because of choking", but we often meet people who are more serious than "giving up eating because of choking" when taking drugs. They only care about the side effects, not its effects. In that case, isn't it more reassuring to get sick without treatment? Our most common and safest penicillin antibiotics can still kill people after the skin test is negative. Can we deny their effects just because very few people have serious side effects? The average life expectancy of modern people has been extended, and antibiotics have contributed!

Adolescence is a normal physiological process. The peak of auxin secretion in adolescence is generally more than twice that of normal adults, and the total secretion in one day is more than three times that of normal adults. That is to say, under normal physiological conditions, doubling auxin will not affect health, and there is still a certain gap between our therapeutic dose and doubling. This is also one of the theoretical foundations that auxin can be approved for people who are not short of auxin.

For patients with auxin deficiency, we are used to calling them pituitary dwarfs. Because dwarfism is discriminatory, we don't use this name now, but it doesn't mean that there is no such disease. If auxin is deficient, it will do great harm if it is not supplemented in time. It will not only cause short stature, but also lead to osteoporosis, muscular and sexual dysplasia, easy aging, cardiovascular diseases and metabolic abnormalities. Children lack zinc and calcium and need to be supplemented. Why don't auxin deficiency need to be supplemented? However, auxin deficiency is not obvious, unlike diabetes and insulin deficiency, which will be fatal if it is not supplemented in time.

Because auxin for injection is exogenous after all, it is not secreted by itself, and there are still some side effects. For example, the injection site is often red and swollen. At the same time, because the growth rate of auxin users in the past was generally slow, the growth rate accelerated after use, and the demand for thyroxine increased accordingly. Sometimes the thyroxine is not adjusted in time, or it is over-adjusted, or it may be that the thyroxine is lower or slightly higher. At the same time, because auxin inhibits glucose metabolism, occasionally there will be people with slightly higher blood sugar, and these two drugs need to be reviewed regularly. Others may have headaches, joint pains, etc. , are generally mild. It will be good to reduce the amount or stop for a few days, but it will not be obvious after a period of time. Other serious side effects are extremely rare, and there have been some reports of femoral head slippage abroad recently.

Can auxin promote bone age growth?

It is often said that auxin can promote the growth of bone age. In fact, this view is obviously a misunderstanding. Some people have this view, which is mainly caused by one-sided understanding. Auxin is mostly used in children with auxin deficiency, and their bone age is often lower. After auxin is basically normal, the backward bone age tends to be close to normal bone age, which is easily mistaken for promoting bone age growth. Many children who use auxin have entered adolescence, and the rapid growth of adolescent bone age is easily mistaken for auxin. Because of the medication period, it is easy to consider the influence of drugs if there is any problem. At present, there is enough evidence to show that the bone age of boys can hardly increase after they use aromatase inhibitors (because girls are not suitable and easy to be boyish) so that androgens can not be converted into estrogen (because they have not been officially approved, they have not been used in clinic at present, but only in scientific research), but the dosage of aromatase inhibitors can not resist the secretion of auxin and inhibit the sensitivity of auxin receptors like GnRHa. It shows that the increase of bone age is mainly related to estrogen (boys have estrogen). In addition, if auxin can promote bone age growth, will FDA approve the use of auxin to improve lifelong height? Will so many people spend so much money for long-term use?

Another easy-to-understand example is gigantism. The growth hormone secretion of patients with gigantism is often dozens or even hundreds of times that of normal people. If auxin promotes the growth of bone age, gigantism patients cannot become giants.