Generally, it contains 4 ~ 8 amino acids and has no specificity. Its function is to help nucleophilic proteins enter the nucleus. The difference between nuclear entry signal and peptide guide is that it is identified by water-containing nuclear pores; Nucleation signal is a permanent part of protein, which is not removed in the process of nuclear conduction and can be reused, which is beneficial to the re-entry of nuclear protein after cell division.
There are many kinds of nuclear localization signals, all of which have a positively charged peptide core. The protein of the first NLS sequence is the T antigen (MW=92kDa) of SV40, which is synthesized in the cytoplasm and rapidly accumulated in the nucleus, and is the necessary protein for viral DNA replication in the nucleus.
Its wild-type amino acid sequence is Pro-Lys-Lys-Arg-Lys-Val, and even the mutant NLS (Pro-Lys-Tyr-Lys-Arg-Lys-Val) produced by a single amino acid mutation can prevent this protein from entering the nucleus and staying in the cytoplasm. If this signal is connected to the side chain of random Lys of non-nuclear protein, non-nuclear protein can also be transformed into nuclear protein.
Amino acid introduction:
There are 20 kinds of known basic amino acids, including lysine, threonine, leucine, isoleucine, valine, methionine, tryptophan and phenylalanine, which cannot be manufactured by human body. We call them essential amino acids, which need food to provide. In addition, the human body's ability to synthesize arginine and histidine is not enough to meet its own needs, and it needs to take some from food, which we call semi-essential amino acids. The other ten amino acids can be made by human body, which we call non-essential amino acids.
The balance and proper supply of amino acids is the basic premise of human health. Lack of any kind of amino acid supply will affect the immune system and other normal functions, making people in a sub-health state and more prone to illness. Wuda Hongyuan Amino Acid Capsule (Guangpu type) contains 12 amino acids and 3 vitamins, which can promote the absorption and utilization of amino acids, provide a variety of amino acids for the human body, maintain the basic balance of amino acids in the body and improve the health level of the human body.