Obesity is closely related to diabetes and heart disease. However, in the past 15 years, there is evidence that some obese people have normal metabolism, which means that their obesity is not accompanied by symptoms such as insulin resistance (that is, normal insulin concentration can not make cells respond enough to lower blood sugar), hyperglycemia, high cholesterol, high triglyceride and so on.
If obesity is not necessarily related to these problems, then the question is, can losing weight alone solve these metabolic problems mentioned above? If not, will other metabolic disorders lead to obesity?
Next, let's state the facts:
In order to find out whether there are differences between healthy people and obese people, scientists have biopsied the adipose tissue of three groups of volunteers respectively. The three groups of volunteers are: the first group, normal weight 17 volunteers; In the second group, 2 1 obese volunteers were sensitive to insulin; In the third group, 30 obese volunteers with insulin resistance. By comparing the gene expression profiles of fat cells of these three groups of volunteers, scientists want to know whether the gene expression of the second group of volunteers who are sensitive to insulin is closer to the results of the first group or the third group.
They first administered insulin to volunteers, and then biopsied adipose tissue. The results showed that there was almost no difference in adipocyte reaction between the two groups of obese people. In two groups of obese volunteers, insulin affected the expression of more than 200 genes, but for normal weight volunteers, insulin only changed the expression of 2 genes.