Ulcer is a non-granulomatous inflammation.
Ulcer pathology
Active phase and remission phase have different manifestations:
1.
active stage
① Diffuse and chronic inflammatory cells, neutrophils and eosinophils infiltrated in intima;
② Acute inflammatory cell infiltration in crypt, especially neutrophil infiltration between epithelial cells, cryptitis,
Even form a crypt abscess, which can break into the lamina propria;
③ Epithelial hyperplasia of crypt,
Goblet cells decreased;
④ mucosal surface erosion can be seen,
Ulcer formation,
Granulation tissue hyperplasia.
2. Remission period
① Neutrophils disappeared and chronic inflammatory cells decreased;
② The size and shape of the depression are irregular,
grade
Disorder. ③ The gap between glandular epithelium and muscularis mucosa is enlarged;
④ Paneth cell metaplasia.
Pathological examination, naked eye and histology of surgical specimens can reveal the above characteristics of ulcerative colitis.