1(HBsAg- hepatitis B virus surface antigen) is a sign that the virus has been infected, but it does not reflect whether the virus has been replicated, the degree of replication and infectivity.
2(HBsAb- hepatitis B virus surface antibody) is the sign of neutralizing antibody and the main sign of recovery or drug resistance. Hepatitis B vaccination, if only this positive, should be regarded as a normal phenomenon after hepatitis B vaccination;
3(HBeAg- hepatitis B virus E antigen) is a sign of virus replication. Persistent positive for more than 3 months tends to be chronic;
4(HBeAb- hepatitis B virus E antibody) is the stop sign of virus replication. Virus replication is reduced, and its infectivity is weak, but it is not completely non-infectious;
5(HBcAb- hepatitis B virus core antibody) is a sign of being infected or being infected. The core antibody IGM is a sign of recent infection or virus replication, and the core antibody IgG will be produced after infection, which is of certain significance to assist the two-and-a-half examination.
Another index of pre-S 1 antigen triple virus replication has little clinical significance.
Because the core antigen is not easy to be detected in blood, there are not enough kits at present, and there are two and a half antigens and antibodies left, which is often called "hepatitis B two and a half" test or "hepatitis B five" test.
The following are the clinical significance of hepatitis B virus serum markers (commonly known as hepatitis B five or two and a half):
[Edit this paragraph] Clinical significance
Clinical significance of serial number HBsAg HBsAb HBeAg HBeAb HBcAb
9 common patterns
1- I have never been infected with HBV before and now.
No anti-HBs was detected in 2-+( 1) previous infection; (2) HBsAg has disappeared and anti -HBs has not appeared in the recovery period; (3) asymptomatic HBsAg carrier.
3-++( 1) has been infected with HBV；; Before; (2) recovery period of acute HBV infection; (3) A few specimens are still infectious. ①HBV infection has passed; ② Window period before anti -HBs appears.
4-+-( 1) immunized with hepatitis B vaccine; (2) previous infection; ③ False positive.
Rehabilitation after 5-+++ acute HBV infection.
6+-+( 1) acute HBV infection; (2) chronic HBsAg carriers; (3) Weak infectivity.
7-+++ infection in the past, still have immunity. HBV infection, recovery period.
8+++(1) acute HBV infection tends to recover; (2) chronic HBsAg carriers; (3) Weak infectivity. Commonly known as "Xiao Sanyang".
9++-+ Acute or chronic hepatitis B infection. This indicates that HBV replication is highly contagious. Commonly known as "three suns".
Six or seven years ago, the doctor said that I had hepatitis B antibody (not vaccinated).
Yes, what the doctor said was.
No anti-HBs was detected in 2-+( 1) previous infection; (2) HBsAg has disappeared and anti -HBs has not appeared in the recovery period; (3) asymptomatic HBsAg carrier.
3-++( 1) has been infected with HBV；; Before; (2) recovery period of acute HBV infection; (3) A few specimens are still infectious. ①HBV infection has passed; ② Window period before anti -HBs appears.
But in July this year, I went for a physical examination and said I was infected.
Yes, a single 5- Yang and 4-5- Yang Can can be converted into a small 3- Yang and a large 3- Yang.
Became a semi-carrier (that is, antibodies have been destroying antigens)
The term "semi-carrier" is relatively new, but it is not standardized. (That is to say, antibodies have been destroying antigens. ) Who invented this term?
After people are infected with HBV virus, people who are not cleared within 6 months are called chronic HBV infection. Age at the time of infection is the most important factor affecting chronic disease. In perinatal period and infancy, 90% and 25%~30% of HBV infected people will develop chronic infection [11] (Ⅰ). The natural history of HBV infection can generally be divided into three periods, namely, immune tolerance period, immune clearance period and inactive or low (no) replication period [12]. During the immune tolerance period, HBV replication was active, serum HBsAg and HBeAg were positive, HBV DNA titer was high (> 105 copies /ml), serum alanine aminotransferase (ALT) level was normal, and liver histology was normal. In the immune clearance period, the serum HBV DNA titer was >: 105 copy /ml, but it was generally lower than that in the immune tolerance period. The ALT/ aspartate aminotransferase (AST) increased continuously or intermittently, and the liver histology showed necrosis and inflammation.
In the inactive period or low (no) replication period, HBeAg is negative, anti -HBe is positive, HBV DNA can not be detected (PCR method) or below the detection limit, ALT/AST level is normal, and there is no obvious inflammation in liver histology. It is called a carrier.
How can you be infected with antibodies?
That depends on what kind of antibody it is. HBsAb- hepatitis B virus surface antibody will not be infected, and HBeAb- hepatitis B virus E antibody is a sign that virus replication is reduced or stopped. HBcAb- hepatitis B virus core antibody is a sign of being infected or being infected. These three antibodies are different.
In this case, when is it most likely to be infected? Is it possible that it was in the last six months or a month or a few days, or a few years ago? )
I have been infected for a long time, maybe a few years ago or when I was born.
The Guide to Prevention and Treatment of Chronic Hepatitis B states:
China is a high epidemic area of HBV infection, and the positive rate of HBsAg in general population is 9.09%. The positive rates of HBsAg in people vaccinated with and without hepatitis B vaccine were 4.565438 0% and 9.565438 0% [8] (Ⅲ) respectively. The prevalent HBV serotypes in China are mainly adrq+ and adw2, and a few are [9]ayw3 (mainly found in Xinjiang, Tibet and Inner Mongolia Autonomous Region). Genotypes are mainly C and B [7].
HBV is mainly transmitted through blood and blood products, mother and baby, damaged skin and mucosa and sexual contact. Perinatal (perinatal) transmission is the main mode of mother-to-child transmission, mostly through the blood and body fluids of HBV-positive mothers during childbirth (ⅰ). Transdermal transmission mainly occurs in the use of medical instruments and syringes that are not strictly disinfected, invasive diagnosis and treatment operations and operations [1, 10] (II-2), and intravenous drug use (I). Others, such as pedicures, tattoos, earrings, accidental exposure of medical staff at work, use of razors and toothbrushes, can also spread (Ⅲ). Sexual contact with HBV-positive people, especially those with multiple sexual partners, will significantly increase the risk of HBV infection (ⅰ).
In my opinion, you are a carrier infected with hepatitis B virus for a long time. At present, your condition fluctuates slightly, so you don't need to take medicine for the time being. You should check four liver functions every three months, namely, cereal, cereal, total bilirubin and indirect bilirubin. If problems are found, the scope of examination can be expanded and symptomatic treatment can be given.
Look at this more: /view/ 10823.html? tp=0_00