Can Enshi travel in April 2022?

Of course.

As long as they don't come from the risk area, as long as the health code is green and they haven't been to the middle and high risk area in travel itinerary, they can enter.

Enshi Tujia and Miao Autonomous Prefecture belongs to the monsoon mountain climate, which is not too hot in summer and too cold in winter. It is suitable for sightseeing all year round, but it is best to visit in April-May.