2 English reference Teapol
Tea polyphenols [Xiangya Medical Dictionary]
3 Overview of Tea Polyphenols Tea polyphenols are the general name of phenolic substances and their derivatives in tea, not a substance, so they are often called polyphenols. Tea polyphenols used to be called tea tannin and tea tannin. The content of tea polyphenols in tea is generally 15%-20%.
The main component of tea polyphenols is flavanol, and flavanol is catechin. The content of catechin accounts for about 70% of the total amount of tea polyphenols.
Tea polyphenols are polyphenolic compounds separated and purified from natural plant tea. It accounts for about 25% of the dry weight of tea, including catechins, flavonoids and flavonols, anthocyanidins, phenolic acids and peptides. A large number of studies have shown that tea polyphenols have a variety of health care functions and pharmacological effects, such as antibacterial, antiviral, antitoxin, cancer prevention, antimutagenesis, lowering blood lipid and blood sugar, preventing arteriosclerosis and thrombosis, protecting the liver, anti-aging, caries prevention and anti-allergy. In addition, it also has a good preventive and therapeutic effect on immune system diseases, especially AIDS.
Clinical study on tea polyphenols 1. Antibacterial effect
As a broad-spectrum, potent and low-toxic antibacterial drug, tea polyphenols have been recognized by scholars in many countries around the world. In many antibacterial tests, it has been found to be effective against Proteus vulgaris, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Botox, Lactobacillus, Vibrio cholerae, Vibrio flavus, Vibrio parahaemolyticus, Bacillus cereus, subspecies hydrophilis, Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa, Shigella flexneri, Shigella sonnei, Salmonella typhi, Bacillus paratyphi and Staphylococcus haemolyticus. At the same time, it can effectively prevent the infection of drug-resistant staphylococcus, and has inhibitory activity on hemolysin, electrocardiogram and EGCG. In addition, tea polyphenols also have a strong inhibitory effect on pathogenic fungi that can cause human skin diseases, such as tinea capitis, tinea versicolor, tinea sweating and stubborn tinea.
Although tea polyphenols have a very powerful killing and inhibiting effect on bacteria in the intestine, they have a protective effect on beneficial bacteria in the intestine. For example, it can promote the growth and reproduction of Bifidobacterium in the intestine, improve the microbial structure in the intestine, improve the immune function of the intestine, and play a positive role in improving human health.
From the research reports so far, the research on the antibacterial active components of tea polyphenols mainly focuses on catechins (EC, ECG, EGC, EGCG) and flavonoids, especially catechins, which are the most extensive and thorough.
2. Antiviral effect
Tea polyphenols is not only an effective broad-spectrum antibacterial drug, but also has a strong antiviral effect. The extracts of green tea and black tea can inhibit influenza A and B viruses. These two viruses penetrate into the cells of animals by using the protrusions on their surfaces, and infect and reproduce in the cells. In addition, tea polyphenols also have strong antagonistic and inhibitory effects on gastroenteritis virus, hepatitis A virus and plant virus.
Studies have confirmed that tea polyphenols are indeed strong inhibitors of human immunodeficiency virus reverse transcriptase.
3. Anti-cancer and antimutagenic effects
Many countries at home and abroad have reported studies on the anti-cancer, anti-cancer and anti-mutation of tea. A large number of studies have confirmed that tea can not only inhibit a variety of chemical carcinogens (benzopyrene, aflatoxin, nitrosomethylurea (NMU), acetamido (AAF), 3-methyl cholanthracene (3Mea), dimethyl benzoanthracene (DMBA), 12O tetradecyl amyl acetate B(TPA), ethyl nitrosamine (DENA), N-methyl. Therefore, tea has different preventive and therapeutic effects on esophageal cancer, gastric cancer, liver cancer, intestinal cancer, lung cancer, skin cancer, breast cancer and cloned cancer, especially on gastric cancer and liver cancer of digestive system. According to the principle of superoxide dismutase, Zhao Zezhen and Huang Minti tested the mutagenicity of tea and the inhibitory effects of six anti-tumor drugs (mitomycin C(MMC), Pingyangmycin, fluorouracil, cisplatin, cytarabine and nitrogen mustard hydrochloride). The results show that tea has no mutagenic effect on cancer, but has antimutagenic effect, and also inhibits the mutagenic toxicity of six anticancer drugs.
4. Antioxidant activity
In normal life activities, people will constantly produce harmful free radicals due to metabolism. Free radicals are very active in nature and have strong oxidation ability, which can induce the oxidation of unsaturated fatty acids in vivo and produce lipid peroxide (LPO). The continuous production and accumulation of LPO in the body will weaken and destroy the normal function of biofilm, affect the normal metabolism of active substances, and promote the occurrence of hepatitis, cancer, aging and cardiovascular diseases. Therefore, eliminating harmful free radicals in the body is of great significance to protect people's health.
Tea polyphenols extracted from tea are a kind of chemical substances containing polyphenol hydroxyl groups, which are easily oxidized into quinones to provide protons H+, so they have remarkable antioxidant properties. It is precisely because of the strong hydrogen supply ability of tea polyphenols that it can obviously eliminate harmful free radicals in the body. Experiments show that tea polyphenols have a strong scavenging effect on reactive oxygen radicals (OFR) in human polymorphonuclear leukocyte system (PMIV), and its scavenging ability is much higher than that of known antioxidants ve and VC. The specific research shows that the antioxidant capacity of tea polyphenols is 18 times of VE and 3 ~ 10 times of VC. Using this strong oxidation ability of tea polyphenols, it can eliminate free radicals in the body, block the generation of N nitroso compounds, and inhibit the activities of lipoxygenase and lipid peroxidation, so that it shows superior therapeutic effects in many aspects such as cancer prevention, anticancer, mutation resistance, anti-aging, prevention and treatment of cardiovascular diseases and hepatitis.
Tea polyphenols can inhibit lipid peroxidation damage caused by oxygen free radicals and imbalance of free radical metabolism in vivo. At the same time, antioxidant components can also prevent and inhibit toxic cells and cell infections. Therefore, it also has the functions of protecting the normal metabolism of the liver and detoxifying.
5. cardiovascular diseases
Cardiovascular disease is the most common disease with the highest mortality in the world. Its incidence rate is very high, especially among middle-aged and elderly people. This is because with the increase of age, the functions of various tissues and organs of the body begin to decline, cholesterol begins to accumulate in the body, blood lipid content increases, blood viscosity increases, and fluidity decreases, which easily leads to blood examination, thickening of blood vessel wall, narrowing of lumen, decreasing toughness of blood vessel wall and increasing brittleness, thus leading to cardiovascular diseases, such as hypertension, coronary heart disease, atherosclerosis, myocardial infarction and hyperlipidemia. In recent years, a large number of scientists at home and abroad have proved that tea polyphenols have the functions of anticoagulation, fibrinolysis, platelet aggregation, blood pressure reduction, blood lipid reduction, prevention and treatment of atherosclerosis, myocardial protection and so on.
The antihypertensive effect of polyphenols in tea is also obvious.
6. Anti-allergic and anti-inflammatory effects
Tea polyphenols have anti-allergic effect.
Tea polyphenols not only have the above pharmacological effects, but also have gastrointestinal protection function, and also have certain effects on lowering blood sugar and treating diabetes. In addition, it is reported that tea polyphenols can be used to resist dental caries, eliminate bad breath, lose weight, and beautify.
5 instructions for tea polyphenols 5. 1 drug name tea polyphenols
5.2 English name Teapol
5.3 The alias of tea polyphenols can protect the heart and brain; Tian Li Sports Insurance; Heart and brain health
5.4 Classification of Blood Drugs >: Anticoagulants
5.5 dosage form100 mg; ;
2. Capsule: 100mg.
5.6 Pharmacological Effects of Tea Polyphenols Tea Polyphenols are extracted and separated from tea leaves, which have the functions of anticoagulation, promoting fibrinogen dissolution, preventing platelet adhesion and reducing plasma fibrinogen.
1. has a strong scavenging effect on harmful free radicals.
2. Anti-aging effect.
3. radiation resistance.
4. Inhibitory effect on cancer cells.
5. Antibacterial and bactericidal effects.
6. Inhibitory effect on HIV.
5.7 Pharmacokinetics of tea polyphenols (unclear)
5.8 Indications of tea polyphenols 1. It can be used for treating cardiovascular diseases such as atherosclerosis, high fibrinogen and leukopenia caused by tumor radiotherapy and chemotherapy.
2. Treat dizziness, chest tightness, shortness of breath, listlessness and other symptoms.
5.9 Contraindications of tea polyphenols (unclear)
5. 10 Precautions (unclear)
5. 1 1 tea polyphenols have fewer adverse reactions.
5. 12 tea polyphenols usage and dosage 200mg each time, 3 times a day. 1 month is 1 course of treatment for cardiovascular patients; For tumor patients undergoing radiotherapy and chemotherapy, 2 months is 1 course of treatment.
5. 13 drug interaction (unknown)
5. 14 Expert opinion