Thrombolytic effect. Hirudin can inhibit platelet aggregation and dissolve thrombus caused by thrombin. Hirudin is a methanol extract, which can activate the chemical fiber dissolution system in vitro and in vivo. The salivary gland secretion of leech has strong antithrombotic effect after intravenous injection in rats. Platelet suspension. Hirudin can inhibit the combination of thrombin and platelets, promote the dissociation of thrombin and platelets, and inhibit the release of platelets stimulated by thrombin and the reaction induced by thrombin. Effect on hemorheology. Feed leech extract 0. 45g/kg can reduce blood viscosity and shorten erythrocyte electrophoresis time. Leech decoction can also reduce the whole blood specific viscosity, plasma specific viscosity, hematocrit and fibrinogen content in rats with abnormal hemorheology.
Hypolipidemic effect. Leech powder (65438 0g/animal) gaves the stomach to hyperlipidemic rabbits every day. Both preventive and therapeutic drugs can reduce the contents of cholesterol and triglyceride in blood, and at the same time, the lesions of aorta and coronary artery are lighter than those in the control group, and the plaques are obviously subsided, which is characterized by collagen fiber proliferation and cholesterol crystallization reduction. Effect on cardiovascular function. Intraperitoneal injection of hirudin (30g/kg) can obviously increase the ability of myocardial uptake of 86Rb in mice, indicating that it can increase myocardial nutrient blood flow. Termination of pregnancy. Leech wide body can terminate the early, middle and late pregnancy in mice.