1. Three * * identical pathological factors related to the occurrence and development of modern chronic diseases (three * * * identical pathological factors)
Let's talk about lesions first. The occurrence and development of diseases need a process, which cannot be achieved overnight. Whether it is exogenous pathogenic factors, such as polluted air, water, unreasonable diet, or endogenous factors, such as stress and fatigue, the diseases caused by them will first cause some abnormal pathological changes in the body and then evolve into symptomatic diseases. Therefore, abnormal pathological changes constitute a very important pathogenesis basis and condition. Now common chronic diseases, such as heart disease, Alzheimer's disease, cancer, diabetes and so on. There doesn't seem to be much correlation between them, but in fact the pathological changes they experienced before onset are the same. In order to prevent and treat diseases, we must first eliminate these abnormal lesions, and then we can really restore health.
After more than 30 years of scientific research, Professor Kang summed up three important abnormal pathological changes, which are the basis of a series of modern chronic diseases. They are: chronic low-grade inflammation, increased lipid synthesis and disorder of intestinal flora.
(1) Chronic low-grade inflammation
The occurrence of inflammation is originally good, and it is a defensive process for immune cells in the body to remove some foreign bodies or necrotic cells. But usually this process is very fast, coming and going in a hurry, reflecting a dynamic balance. However, when the body produces too many proinflammatory substances, or the mechanism of resisting inflammation weakens, this balance will be broken; If this imbalance persists, it will turn the inflammatory defense process that can be solved quickly into a protracted war, and the inflammatory reaction that lasts for a long time will eventually evolve into chronic inflammation. What deserves our attention is not chronic inflammation caused by acute inflammation, but chronic systemic low-grade inflammation.
This kind of inflammation is usually caused by metabolic disorder or "internal injury" of cells in the body, and generally does not show symptoms, so it is not easy to be detected, so its threat to human health is silent and extremely risky.
Consequences of chronic systemic low-grade inflammation: on the one hand, persistent inflammation may cause damage to cells and tissues in our body;
On the other hand, the substances it produces can induce the expression of some pathological genes, thus forming the material conditions and foundation needed for the occurrence and development of diseases. For example, it can cause cell DNA damage and induce cancer; It will cause damage to islet cells and cause diabetes; It will cause damage to the blood vessel wall and cause cardiovascular diseases; It can cause brain cell damage, Alzheimer's disease and so on.
So, usually, this gradual and slow change is like boiling a frog in warm water. Although there are no obvious symptoms, its existence is like a fuse, which can detonate many chronic diseases at any time.
(2) Increased lipid synthesis.
How to control and eliminate chronic systemic low-grade inflammation is the key to prevent and treat diseases. Lipid metabolism plays an important role in the occurrence and development of chronic inflammation, and its abnormality is the second most important abnormal pathological change. Fat synthesis is also in dynamic equilibrium under normal circumstances. At present, the unreasonable diet structure promotes the rapid and massive synthesis of fat, and excess fat can be stored in the liver and become fatty liver; Stored under the skin and abdomen, causing obesity; Swimming to the cardiovascular and cerebrovascular diseases, leading to cardiovascular and cerebrovascular diseases.
Excessive fat synthesis is often an important condition for the rapid growth of tumor cells, which creates a suitable "hotbed" for tumor growth. Therefore, the increase of fat synthesis is the second important pathological change.
(3) Intestinal flora imbalance
The third important pathological change is intestinal flora imbalance. With the deepening of research, researchers found that the composition, quantity and proportion of intestinal bacteria played a decisive role in the occurrence and development of diseases. Because the composition and quantity of intestinal flora will not only affect the digestion and absorption of nutrients, but also affect the chronic inflammatory reaction and fat synthesis, producing many small molecules, which enter the body fluid through the intestinal mucosa and flow to the whole body, thus changing the expression of related pathological genes and affecting the metabolic balance in the body. For example, when the intestinal flora is disordered, a large number of harmful bacteria produce endotoxin and enter the body fluid circulation, further promoting chronic inflammation. Therefore, once the intestinal bacteria are disordered, it will not only cause discomfort in the intestine itself, but also cause changes in the physiological functions of other organs.
To sum up, chronic low-grade inflammation, increased fat synthesis and disorder of intestinal flora are the basis of a series of chronic diseases. It is worth noting that these three diseases are closely related to nutritional factors, which coincides with the saying that "the disease enters from the mouth". Therefore, these three diseases are very critical and sensitive intermediate links between diet nutrition and disease. Finding out which nutrients are excessive and which nutrients can prevent and correct these three diseases is the key to determine effective nutritional intervention programs and prevent and correct these three diseases.