Duzallo, a new American drug
On Aug. 2, 2065438, Kloc-0, the FDA approved Duzallo(Ironwood) to treat gout-related hyperuricemia in patients who did not reach the target serum uric acid level, in which allopurinol with a medically appropriate daily dose was used alone. Duzallo is not recommended for the treatment of asymptomatic hyperuricemia.
This fixed dose compound product combines uric acid transporter 1 inhibitor (URAT 1) with allopurinol and xanthine oxidase inhibitor in one tablet. Allopurinol can selectively inhibit UA transporter URAT 1 which is responsible for most renal UA reabsorption, and reduce uric acid production, while sphingosine can increase uric acid excretion.
2. Acid-lowering artifact: uric acid oxidase
Uricase is grayish white or brownish green crystal or bright transparent sheet, which is almost insoluble in water and slightly soluble in alkaline buffer. It can quickly oxidize uric acid into allantoic acid, which is no longer absorbed by renal tubules and excreted. It has a good curative effect on hyperuricemia caused by nodular gout, urinary calculi and renal failure.
3. A new Japanese drug: Topiramate
Tropistat is a selective inhibitor of non-purine xanthine oxidase, which can selectively and reversibly inhibit xanthine oxidoreductase and reduce serum uric acid level. Tropistat is a mixed inhibitor, which shows a dual inhibitory effect based on structure and mechanism (it is the suicide substrate of XOR). The binding mode is the same as that of febuxostat, which binds to the same hydrophobic cavity of the enzyme, but the difference is that it can form amo -O-C * * valence bond with the molybdenum pterin center of the enzyme, which inhibits the combination of the enzyme and the substrate, thus playing an anti-gout role. It is precisely because of the long decomposition half-life of topiramate -XOR complex that it shows a long-term uric acid reduction effect, which is better than that of budistat.
4. The natural enemy of gout: Yifengqing
Yifengqing used carnosine and four experts to regulate patients' uric acid. Low-molecular-weight goose carnosine was extracted from deep-sea tuna, and made into uric acid-reducing products by scientific blending, which had remarkable effect in animal experiments. As a functional food, its effect was supported by a large number of cases.