1, Five Ways to Eat Liver Injured by Drugs
Hepatotoxicity of the drug itself. The liver is the "detoxification factory" of the human body, which is responsible for detoxifying almost all foods and drugs that enter the human body. Drugs with "three-point toxicity" are more likely to directly harm the liver. Statistics show that there are more than 900 kinds of drugs that can cause drug-induced liver injury. Especially anti-tuberculosis drugs, lipid-lowering drugs, antibiotics, anti-tumor drugs, antipyretic and analgesic drugs, sleeping pills and other six kinds of drugs. In the process of metabolism, the chemical components of the above drugs will destroy liver cells. For example, anti-tuberculosis drugs and their metabolites have strong affinity for macromolecules, which will interfere with or destroy the normal metabolism of these macromolecules, such as genetic materials such as DNA and RNA, thus causing liver damage. Therefore, the use of these drugs must be in accordance with the doctor's advice to avoid excessive dosage or long medication time.
An overdose. Dr. Molly Cook, president of the American College of Physicians, once stressed that the overuse of prescription drugs has reached the most serious situation in the past 10~ 15 years. Clinically, cold medicine, sleeping pills, antiasthmatic drugs, painkillers, antibiotics and so on. Most likely an overdose. These drugs all have one thing in common: many patients take them according to the instructions, but the symptoms are not eliminated in time as expected, so they will take them again at intervals other than the doctor's advice, resulting in overdose. Drugs such as paracetamol (acetaminophen) are found in many cold medicines and painkillers with different trade names, which is easy to cause overlapping use. Patients are advised not to take multiple similar drugs at the same time. Read the instructions carefully before taking them. If you are not sure, you'd better consult a doctor or pharmacist.
Multiple drugs are used together. Many drugs themselves will not cause obvious damage to the liver, but if used with other drugs, the impact on the liver may become greater. When two or more drugs act at the same time, it is difficult for the liver to resist the "double blow" and the probability of injury is naturally greater. For example, the combination of allopurinol and mercaptopurine can increase the hepatotoxicity of drugs. Ethanol can also aggravate the hepatotoxicity of drugs, so it is not advisable to drink alcohol during taking drugs that damage the liver. The US Food and Drug Administration (FDA) has also warned that when taking statins such as simvastatin, atorvastatin and pravastatin, drinking a lot of grapefruit juice or fresh grapefruit may promote the accumulation of drugs in the body and increase liver damage.
Improper use of traditional Chinese medicine. Many people think that Chinese medicine is mild in temperament and has little toxic effect on the body. In fact, Chinese medicine pays attention to syndrome differentiation, compatibility and attenuation, and reduces the impact on the liver. However, some medicinal materials also have hepatotoxicity, such as Zhuanggujie Pill, Xiaoyin Tablet (Pill), Liushen Pill, Gegen Decoction, Fangfeng Tongsheng Powder, Shiduqing, Xiaokechuan Tablet, Niuhuang Jiedu Tablet and Tianma Pill. Moreover, Chinese medicine must be strictly distinguished by Chinese medicine, and the quantity must be well grasped in order to reduce the toxicity as much as possible. Therefore, when taking Chinese medicine or proprietary Chinese medicine, you must consult a professional Chinese medicine practitioner, and you must not believe in folk remedies and take Chinese herbal medicines indiscriminately.
Children and adults use drugs. When there is no special dosage form for children, adult medicine can be given to children. At this time, you must follow the doctor's advice to reduce the amount. This is because children's liver metabolic ability is not as good as that of adults, and it is difficult for adults to grasp the dosage of drugs given to children, which may lead to liver damage. Such as paracetamol and erythromycin. It has been proved that it is more likely to cause liver damage in children. Parents are advised to choose a special dosage form for their children, not to give them drugs simply by experience, and not to give them adult drugs easily. When there is no dosage form suitable for children, it is necessary to seek medical attention in time, and under the guidance of a doctor, accurately calculate the dose according to the kilogram weight to prevent liver damage in children.
2. Do you take medicine after breakfast?
1. Drugs that must be taken before meals
Some drugs need to be taken before meals, usually 10- 30 minutes before meals. At this time, there is no food in the stomach, and the absorption and utilization rate of drugs is the highest, which can maintain the blood concentration of the body and quickly play the role of drugs.
Generally, these drugs have little stimulation to the gastrointestinal tract, and the drugs often taken before meals include drugs to protect the spleen and stomach, drugs to stop diarrhea, drugs to protect the stomach wall, and nourishing drugs. In addition, most Chinese medicines need to be taken before breakfast.
2. Drugs that must be taken with meals
There are very few drugs that need to be taken when eating. Generally, these drugs are digestive AIDS, which can help the digestion of the stomach when taken at meals. Such as multienzyme tablet, pepsin mixture, etc.
3. Drugs that need to be taken after meals
Most drugs need to be taken after meals, especially western medicine. It is usually taken 30 minutes after meals. At this time, there are some foods in the stomach, which can reduce the stimulation of the gastrointestinal tract after the food enters the stomach.
In addition, take it half an hour after meals, at this time, some food has entered the intestine, and the medicine will not be mixed with food after entering, which will affect absorption.
4. Drugs that need to be taken on an empty stomach
Some drugs should not be taken before or after meals, which can not only avoid the influence of food on drugs, but also make drugs enter the intestine quickly and maintain a high concentration, which has good curative effect.
For example, some anthelmintics need to be taken on an empty stomach, and parasites are mostly in the intestines. Taking medicine on an empty stomach can quickly reach the lesion site, with rapid absorption and high blood concentration.
5. Drugs that need to be taken on time
The taking of some drugs has little to do with before and after meals, because it takes a certain time to maintain a certain blood concentration. For example, some sustained-release tablets release drugs at a uniform speed, and if they are not taken again after a certain period of time, the blood concentration in the body will decrease and the food efficacy will decrease. However, some antibiotics can last 4-6 hours. After this time, the blood concentration in the body will drop and it will not play a role in treating diseases.
Therefore, different drugs have different medication methods, and many times they should be taken according to the doctor's advice and cannot be used blindly.
Every drug has a prescribed way of taking it. If you take the medicine incorrectly, it will do some harm to your body, but your personal performance is different. Some people taking the same medicine will have great side effects, but some people will be fine. This is a manifestation of individual differences. Five ways of taking medicine will harm the liver, please stay away.