Yuting instruction
Drug name
Product name: Yuting
Generic name: levonorgestrel tablets
English name: fat emulsion injection
composition
Each tablet of this product contains 0.75 mg of levonorgestrel as the main component. The auxiliary materials are starch, lactose, sucrose, dextrin, magnesium stearate and sodium carboxymethyl starch.
indicate
Used for female emergency contraception, that is, when there is no protective measures or other contraceptive methods fail unexpectedly.
dosage
Oral, take 1 tablet 72 hours after sexual intercourse, and take the second tablet every 12 hours.
counteraction
1. Menstrual changes can be seen, most of which are manifested as early or late menstruation in the month of taking medicine. 2. Mild nausea, vomiting, breast tenderness, headache, dizziness, fatigue and other symptoms may occur, generally without treatment, and may disappear after 24 hours. If the symptoms are severe or persistent, you should consult a doctor. 3. There may be abnormal uterine bleeding. If the bleeding can't disappear by itself, you should go to the hospital in time and be alert to the existence of ectopic pregnancy.
taboo
Known or suspected pregnancy is prohibited.
Breast cancer, reproductive organ cancer, abnormal liver function or recent history of liver disease or jaundice, venous thrombosis, cerebrovascular accident, hypertension, cardiovascular disease, diabetes, hyperlipidemia, mental depression and women over 40 years old are prohibited.
Matters needing attention
1. This product is an emergency remedy contraceptive for contraceptive errors, not an induced labor drug. 2. This product cannot be used as a routine contraceptive method, and frequent use is not recommended. Reliable contraceptive measures should be taken after taking medicine and before the next menstruation. 3. If vomiting occurs within 2 hours after taking the medicine, you should take 1 tablet immediately. 4. If menstruation is overdue 1 week, and there is a possibility of pregnancy, it is necessary to have a pregnancy test or consult a doctor further. 5. If irregular uterine bleeding or severe abdominal pain occurs about 3-5 weeks after taking the medicine, you should seek medical advice in time to rule out ectopic pregnancy. 6. This product is used for people over 17 years old. /kloc-Please consult a doctor if you need to use it under 0/7 years old. 7. It is recommended that lactating women stop breastfeeding for at least 3 days after taking this product, during which they should regularly express milk. 8. It is forbidden for those who are allergic to this product, and those who are allergic.
Medication for special population
Precautions for children:
Precautions during pregnancy and lactation:
Pregnant and lactating women are prohibited.
Precautions for the elderly:
drug interaction
When used with other drugs (especially phenobarbital, phenytoin sodium, rifampicin, carbamazepine, macrolide antibiotics, imidazole antifungal drugs, cimetidine and antiviral drugs, etc.), drug interactions may occur. ). Please consult a doctor or pharmacist for details.
pharmacological action
This product is a quick-acting and short-acting contraceptive. Its contraceptive mechanism is to significantly inhibit ovulation and prevent the implantation of pregnant eggs, increase the viscosity of cervical mucus and increase the penetration resistance of sperm, thus playing a quick contraceptive role.
store
Light-proof seal.
term of validity
60 months.
Registration authentication number
National medicine standard word H 10983 129
Explain the revision date of the manual.
2006/ 12/25 0:00
Production enterprise
Enterprise name: Beijing Zizhu Pharmaceutical Co., Ltd. Production address: No.27, Chaoyang North Road, Chaoyang District, Beijing Tel: 0162250612 If you have any questions, you can contact the manufacturer.
Yu ting's introduction
composition
The main component of each tablet of this product is levonorgestrel 0.75 mg. The auxiliary materials are starch, lactose, sucrose, dextrin, magnesium stearate and sodium carboxymethyl starch.
Character; Role; letter
This product is a white tablet.
Functional category
This product is an over-the-counter oral contraceptive.
indicate
Used for female emergency contraception, that is, when there is no protective measures or other contraceptive methods fail unexpectedly.
standard
0.75 mg.
dosage
Oral, take 1 tablet 72 hours after sexual intercourse, and take the second tablet every 12 hours.
counteraction
Visible menstrual changes, mostly manifested as early or delayed menstruation in the month of taking medicine.
Symptoms such as mild nausea, vomiting, breast tenderness, headache, dizziness, fatigue and so on. , generally do not need treatment, can disappear after 24 hours. If the symptoms are severe or persistent, you should consult your doctor.
There may be abnormal uterine bleeding. If the bleeding can't disappear by itself, you should go to the hospital in time and be alert to the existence of ectopic pregnancy.
taboo
Breast cancer, reproductive organ cancer, abnormal liver function or recent history of liver disease or jaundice, venous thrombosis, cerebrovascular accident, hypertension, cardiovascular disease, diabetes, hyperlipidemia, mental depression and women over 40 years old are prohibited.
Matters needing attention
1. This product is an emergency remedy contraceptive for contraceptive errors, not an induced labor drug.
2. This product should not be used as a routine contraceptive, and reliable contraceptive measures should be taken after taking the medicine and before the next menstruation.
3. If vomiting occurs within 2 hours after taking the medicine, take 1 tablet immediately.
4. This product may advance or postpone the next menstrual period. If menstruation 1 week is still overdue, you should go to the hospital for examination immediately to rule out pregnancy.
5. It is forbidden for those who are allergic to this product, and should be used with caution for those who are allergic.
6. It is forbidden to use this product when its characteristics change.
7. Please keep this product out of the reach of children.
8. If you are using other drugs, please consult a doctor or pharmacist before using this product.
drug interaction
When used with other drugs (especially phenobarbital, phenytoin sodium, rifampicin, carbamazepine, macrolide antibiotics, imidazole antifungal drugs, cimetidine and antiviral drugs, etc.), drug interactions may occur. ). Please consult a doctor or pharmacist for details.
pharmacological action
This product is a quick-acting and short-acting contraceptive. Its contraceptive mechanism is to significantly inhibit ovulation and prevent the implantation of pregnant eggs, increase the viscosity of cervical mucus and increase the penetration resistance of sperm, thus playing a quick contraceptive role.
store
Light-proof seal.
parcel
Aluminum-plastic packaging, per board 1 capsule, per box 1 board.
term of validity
60 months
executive standard
China Pharmacopoeia (20 10 Edition) Part II
Registration authentication number
National medicine standard word H 1 102 1372
Production enterprise
Beijing zizhu drug co., ltd
Revision date
20 10 10 0 1 day
Several common misunderstandings in the use of Yuting
Myth 1: Taking emergency contraceptives will seriously disrupt the menstrual cycle.
Clinical verification shows that 70% of women will have their next menstruation on time after taking Yuting, and 80% of women have no obvious changes in menstrual days and menstrual volume. A few women will have early or overdue menstruation, and it is normal to advance or postpone menstruation for about 7 days.
Emergency contraceptives, such as Yuting, mainly prevent ovulation, prevent sperm from combining with eggs and prevent implantation. After taking levonorgestrel as an emergency contraceptive, menarche is the most common one, which is also called withdrawal bleeding in medicine. Although it has the characteristics of menstruation, it is not really menstruation. Is this how Yu Ting plays the role of emergency contraception? Virtual menstruation? To complete, so it is normal to have certain changes in menstruation after taking emergency contraception, because individual differences may or may not be obvious. It will return to normal in a short time after stopping taking medicine, so there is no need to worry that emergency contraception will disrupt the menstrual cycle. One of the main reasons why the World Health Organization and the national family planning department promote the use of levonorgestrel as a remedial measure is that this drug has strong reversible characteristics. Its reversibility is reflected in the fact that the signs can return to normal in a short time after stopping the drug, and the menstrual changes are no exception.
Myth 2: You can take emergency contraceptives such as Yuting at any time.
As an oral drug, Yuting is well absorbed in the gastrointestinal tract, and its blood concentration can reach the peak after 1 hour. In order to effectively maintain the drug concentration, according to the requirements of pharmacokinetics, Yuting can take it within 72 hours to ideally ensure the best contraceptive effect of the drug. The earlier she takes it during this period, the better the effect.
As a new family planning project in China, emergency contraception has gradually become familiar to women of childbearing age, but there have been many misunderstandings in its use for a long time, leading to contraceptive failure. The most important thing to use emergency contraception is to grasp the time, that is, take it within 72 hours after the event, and the sooner you take it, the better the effect, rather than taking it at any time after the event.
The contraceptive mechanism of emergency contraceptive represented by Yuting is to significantly inhibit ovulation and prevent pregnant eggs from implantation, increase the viscosity of cervical mucus and the resistance of sperm penetration, thus playing the role of quick-acting contraception. This mechanism itself determines that medication must be timely and effective.
In order to give full play to the role of emergency contraception, in addition to correctly understanding the use time, we should also pay attention to the following points:
First, if you are sure that you are pregnant, there is no need to take emergency contraceptives such as Yuting. Although it will not affect the health of the fetus or cause abortion after taking it, there is no need to reinvent the wheel.
Second, if you have unprotected sex again after taking Yuting, there is still the possibility of pregnancy, because all emergency contraceptives are? Remedy afterwards? Its effectiveness is not as good as one-time living. At this time, if you need emergency contraception, you need to take another emergency contraceptive.
Third, some women will vomit after taking the medicine. Remember, if vomiting occurs within 2 hours, you should take another tablet.
Myth 3: Vomiting after taking emergency contraception can be avoided.
Taking emergency contraception such as Yuting is a well-known remedy afterwards, but many people don't know much about the method of taking it, and some people fail to use contraception in the wrong way. In China, the levonorgestrel emergency contraceptive represented by Yuting belongs to over-the-counter drugs and can be obtained from social pharmacies conveniently and quickly. Therefore, users must master the correct method of taking medicine by reading the instructions themselves or through other channels, such as taking supplementary drugs within 2 hours after taking medicine, so as to avoid contraceptive failure. Many people mistakenly believe that everything will be fine if they take emergency contraception within 72 hours. In fact, due to individual differences, a few people may have slight dizziness, nausea, vomiting and other symptoms after taking emergency contraceptives such as Yuting. Although the duration is short and the incidence is low, if vomiting occurs within a short time after taking the medicine, the curative effect will be affected, and the same dose of medicine must be taken in time to solve it, otherwise the probability of contraceptive failure will increase. The specific supplementary method is: if vomiting occurs within 2 hours after taking the medicine, you should take the same dose of the medicine immediately, and the time for taking the medicine for the second time remains unchanged. It is worth noting that if you take a small amount of medicine, you can reduce or avoid nausea and vomiting.
Myth 4: Emergency contraceptives can replace conventional contraceptives.
In order to avoid unwanted pregnancy after unprotected sex, taking emergency contraception such as Yuting is the best remedy, which is not only convenient and fast, but also has ideal contraceptive effect. In addition, emergency contraception is an important supplement to conventional contraception, because every conventional contraception has the possibility of failure, such as condom rupture, loss of short-acting contraceptives, intrauterine device slippage and so on. At this time, emergency contraception is the best remedy.
However, a survey shows that there are many irregularities in the use of emergency contraceptives by many women, and many people don't know much about the methods of taking them. The vast majority of users take it by themselves after purchasing it in social pharmacies, and quite a few people don't read the instructions. Without the guidance of doctors, pharmacists in pharmacies failed to fulfill their educational responsibilities, and misunderstandings and irregular use occurred from time to time. Some people mistakenly think that emergency contraception is a routine contraceptive method, but it is not.
No serious adverse consequences were reported among women who took levonorgestrel emergency contraception more than once in a menstrual cycle.
However, experts still remind the majority of women of childbearing age that emergency contraception is only an emergency remedy and cannot replace conventional contraception, but it is not because of the health risks of emergency contraception, but because of the consideration of contraceptive success rate, because taking it many times in a short time may reduce the success rate of contraception. However, for women who share unprotected rooms or whose contraceptive methods fail, timely application of emergency contraception is the only way out.
Myth 6: Yuting has a great influence on the fetus and lactating women.
The Handbook for Family Planning Service Providers of the World Health Organization is a popular science book compiled by the National Family Planning Commission. In the manual, it is specially set. Emergency contraception question and answer? Column one. One of the problems is. If women use emergency contraception during pregnancy, is it harmful to the fetus? The answer is yes. No, high-level evidence has shown that emergency contraception will not cause birth defects, and if a woman is pregnant when taking the medicine, it will not endanger the health of the fetus? .
As a specific medicine for emergency contraception, Yuting is mainly composed of levonorgestrel, which is a simple progestogen. The pharmaceutical composition is safe and low in dosage. After 48 hours, it can be quickly discharged from the human body without adverse effects on the human body. Not to mention that Yuting will cause miscarriage. Progesterone and antiprogesterone are definitely different, and only a large dose of antiprogesterone can lead to abortion.
At the same time, Yuting only contains a pure progesterone, and does not contain estrogen that affects milk secretion. So? Yu ting? It is an emergency contraceptive suitable for lactating women.
Myth 7: As long as you eat Yuting, you can prevent unwanted pregnancy.
Since the emergency contraception was listed as an over-the-counter drug, the Clinical Research and Training Center of Shanghai Institute of Family Planning Science has monitored and studied the safety of emergency contraception after it was listed, which is a national tenth five-year plan project. The goal of this project is to explore the safety of over-the-counter emergency contraception after marketing, how to prevent and reduce drug misuse and abuse, and provide guidance for future emergency contraceptive technical services.
This study was organized by Shanghai Family Planning Technical Guidance Institute, in conjunction with social pharmacies, and also organized a surgical monitoring point in Shanghai. In addition, emergency contraceptive manufacturers have set up a 24-hour reproductive health hotline to study the safety of emergency contraceptives after they are put on the market. Results: We investigated 3269 cases of abortion in three hospitals in Shanghai. Among these 3269 cases of abortion, 446 cases, 13% were pregnant after using emergency contraception. This shows that emergency contraception also has a failure rate, but more importantly, why is the failure rate higher in reality and only 2% in clinical verification?
When analyzing the specific situation, experts found that the reasons for the failure are concentrated in the following aspects: First, 22% of the methods failed, and they were taken 72 hours later and taken beforehand;
Second, 78% people failed to use it, such as having sex without contraception after taking medicine;
Third, it's over time to eat the second tablet.
The survey also asked people about the source of emergency contraceptives, and nearly 98% were pharmacies. Do I have to get the guidance of a pharmacist to buy medicine? 98% of women said they didn't get guidance. A questionnaire survey was conducted among women under the age of 59 1 name 19 in 6 hospitals, 3 fourth-class hospitals and 3 maternal and child health hospitals. Their average age is a little over 17 years old, and 2 1% of them have used emergency contraception. Among them, the method failure only accounts for 18%, and the use failure accounts for 8 1%. Therefore, the vast majority of pregnant girls are caused by the failure of use. They should read the instructions carefully before taking the medicine. In order to get the emergency contraceptive in time, it is best to leave it at home in case something goes wrong.
Myth 8: After emergency contraception, you can have contraception in the same room again.
Yuting is the most widely used emergency contraceptive, but after investigation, a considerable number of people misuse Yuting, so that they regret their contraceptive mistakes. The most common one is taking Yuting as a preventive measure beforehand, or having unprotected sex after taking it, even though you know you must use it within 72 hours afterwards. It must be pointed out that this is the wrong way to use it, and it is also a misunderstanding of emergency contraception. The emergency contraceptive represented by Yu Ting refers to an emergency remedial contraceptive method used to prevent unintended pregnancy in unprotected sex or after contraceptive failure for a period of time. Visible in ting is? Remedy afterwards? , not? Prevention beforehand? In other words, it only protects the last sexual intercourse and is invalid for the next sexual intercourse. This is different from condoms and must be paid enough attention to. Of course, it is correct to take Yuting in time after the condom falls off and breaks, which is the proper meaning of Yuting's emergency contraception.
Besides defining emergency contraception? Remedy afterwards? In addition to the characteristics, it is also important to remember that if you have unprotected sex many times and only take Yuting once, you may also fail to use contraception because you may have been pregnant in your previous sexual life. Now that you are pregnant, it is meaningless to talk about contraception.
Myth 9: Taking emergency contraception can lead to acne or obesity.
As an after-the-fact remedy, emergency contraception has made outstanding contributions to reducing the rate of unwanted pregnancy and abortion since it was invented in the middle and late last century. Emergency contraception with levonorgestrel has been promoted by the World Health Organization and the national family planning department.
Yuting is the earliest emergency contraceptive listed in China. Its contraceptive mechanism is: inhibiting ovulation, preventing fertilization and preventing implantation. It has been used in China for 13 years, with 400 million users and achieved good social benefits. In recent years, with the opening of social concept, the demand for emergency contraceptives represented by Yu Ting is strong. No side effects leading to obesity or acne were found after being tested by national specialized institutions after listing.
In fact, it is untenable to say that emergency contraceptives have the above side effects, whether from the perspective of drug mechanism or drug dosage. Take Yu Ting's two capsules as an example. The dosage of each capsule is 0.75mg of levonorgestrel. The strong activity of progesterone will be eliminated from the body within 2448 hours after being absorbed by the human body, and it will not stay in the human body, and it will not lead to obesity and acne. It takes effect quickly, metabolizes quickly, gives full play to the role of emergency contraception, and takes it in time afterwards, which is a major feature of emergency contraception.
Those who think that taking emergency birth control pills will cause acne or gain weight are all misunderstandings, and strictly speaking, they are somewhat ignorant? Doctor? Misleading results. At the press conference held by China Medical Accounting Family Planning Branch in Beijing on August 20 10, famous family planning experts, researchers from the State Family Planning Commission and gynecologists from Peking University Hospital once again clarified many misunderstandings about emergency contraceptives such as Yuting. Of course, a small number of people will have physical reactions such as vomiting and nausea after taking the medicine. Some people who take medicine will have their menstruation advanced or delayed, but they will return to normal next month. These are normal reactions.
The latest report of the World Health Organization also pointed out that the emergency contraceptive containing levonorgestrel can be completely metabolized out of the body within three days after entering the human body, and there is no known health risk for repeated use. Even if it is taken more than once in a menstrual cycle, there are no reports of serious adverse consequences and no long-term effects on the human body. If a woman has a pregnancy plan, she can get pregnant in any subsequent one-time behavior. Myth 10: Emergency contraception is effective after 72 hours.
For any serious matter, it is terrible to know one thing and not know the other. Contraception seems out of place in China, but it is undeniable that it is a very serious matter, especially emergency contraception, because it can be done with a little carelessness? Murder? .
Yuting is the most famous and widely used emergency contraceptive in China. Thirteen years after listing, quite a few people in China have known that taking Yuting in time after the event can prevent pregnancy. But most people don't have a correct understanding of when to take emergency contraception. Grasping the time of taking emergency contraception is the most critical place to take emergency contraception. Whether it is clinical verification or post-marketing testing, the conclusion is that taking Yuting in time within 72 hours after the event can prevent unwanted pregnancy, which has long been proved by the practice of hundreds of millions of people. Within 72 hours after the event, the earlier the contraceptive effect, the better, which is also a * * * knowledge. Because emergency contraception, as a remedial measure afterwards, must be urgent in time. If vomiting occurs within 2 hours after taking it, you need to take the same dose of medicine as soon as possible.
Whether Yuting is effective after 72 hours is still under study in medicine. Some studies have increased the time range to 120 hours (five days). From the preliminary results, the effective rate of medication has not decreased significantly, but its effect needs to be further confirmed. But the overall conclusion is clear, that is, the shorter the time from unprotected sex and contraceptive failure, the better the effect.
Myth 1 1: Human factors will not affect the effect of emergency contraception.
Some women take it for granted that they have mastered all the true meaning of taking emergency contraception after mastering the time and method of using Yuting. In fact, a series of human factors can also lead to contraceptive failure, which must be paid enough attention to.
If users of emergency contraceptives suffer from diseases such as colds, fever and acute enteritis, which lead to vomiting, their efficacy will be affected. The following drugs will also have an impact on the efficacy of emergency contraceptives, such as penicillins, macrolides, anti-tuberculosis drugs, anti-epileptic drugs and so on. However, these drugs are widely used in daily life, and if they are not reminded, it is easy to cause emergency contraception failure.
In addition to the above drug interference, the following factors will also directly affect the curative effect, which should attract the attention of users:
1. Smoking can accelerate the metabolism of Yuting, a special emergency contraceptive, and affect its efficacy.
2. Taking emergency contraception many times in the same menstrual cycle will reduce the efficacy of emergency contraception.
3, after taking emergency contraception, before the next menstruation, unprotected sex again.
4. Unprotected sex has occurred many times, and emergency contraceptives such as Yuting have been used only once.
It's too late to take emergency contraception such as Yuting, which exceeds the best effective time of 72 hours.
6. The second medication time exceeds the prescribed interval.
Myth 12: the side effects of emergency contraceptives are particularly great.
This may be the biggest misunderstanding of emergency contraceptives and even all contraceptives in society. At present, all emergency contraceptives available on the market without prescription are composed of levonorgestrel. In addition to the earliest and most well-known royal court on the market, there are many similar products.
The contraceptive mechanism of levonorgestrel emergency contraceptive is: inhibiting ovulation; Prevent sperm from combining with eggs; Prevent fertilized eggs from implanting. Some women will have normal physiological reactions such as vomiting and nausea after taking the medicine, and will recover immediately after stopping taking the medicine. Some women will have their menstrual period advanced or postponed, which is a prominent manifestation of emergency contraception, which becomes withdrawal bleeding in medicine and returns to normal the next month.
The society's one-sided understanding of the side effects of emergency contraception is mainly influenced by irresponsible media reports. Some media quoted doctors unilaterally, ignoring that emergency contraception is an emergency contraceptive method supported and promoted by the World Health Organization and the National Family Planning Commission. Of course, in today's fierce commercial competition, it is often some competitive industries, such as abortion institutions and condom industry, that deliberately discredit emergency contraceptives.
Official website, the World Health Organization (WHO), published the 88th Bulletin of 20 10, which also wrote in particular,? Accurate news reports play an important role in spreading information such as health risks, health behaviors and new products, while sensational and terrible reports may have the opposite effect. As far as emergency contraception is concerned, there have been many well-designed and closely followed multi-center research results around the world. Many years of clinical application have proved that levonorgestrel single dose emergency contraception is safe and reliable, and there is no need to repeat the research. Our urgent task is how to explain and spread science in an easy-to-understand way. ?
Myth 13: Repeated use of emergency contraception can lead to infertility.
Although some women know that emergency contraception can be used as an emergency remedy, even once or twice, when they need it or need it again, they will hesitate: can't emergency contraception be taken multiple times? Will having children in the future be affected? Many people hesitate to have an abortion because they missed the opportunity. In fact, it was compiled by the National Family Planning Commission and published by China Population Publishing House on page 54 of the WHO Handbook for Family Planning Service Providers? Questions and answers about emergency contraception? Li has answered this question horizontally. It is clearly pointed out in the instructions that ECPS (levonorgestrel emergency contraceptive such as Yuting) is also safe to take many times, and its action time is very short. At the press conference held by Family Planning Branch of Chinese Medical Association in August, 20 10, Professor Zheng, a researcher of the National Family Planning Commission and an expert in gynecology in Peking University Hospital, answered this question again. The answer is that emergency contraceptives such as Yuting are safe and reversible, can be metabolized from the body quickly, and can be pregnant normally after stopping taking drugs.
Pharmacologically speaking, the dosage of emergency contraception represented by Yuting is very small, and the dosage taken once is only 1.5mg, which can be excreted from the human body within 24-48 hours, which is not enough to adversely affect the human body and will not affect the future fertility of women. And it is its rapid metabolic characteristics that ensure it? Urgent? The effect of contraception.