First, in the fermentation process, oils and fats are often added to the culture medium as the nutritional components of cephalosporins to promote the growth of cephalosporins and improve the yield of cephalosporins C. After the fermentation is completed, cephalosporins C are obtained through membrane filtration, resin adsorption purification and crystallization, and finally 7-ACA is obtained through chemical cracking or enzymatic cracking. It needs to be separated and purified many times in the production process, so the substances in the culture medium will not affect the quality of 7-ACA products.
Secondly, 7-ACA is only an intermediate for the production of cephalosporins. Using 7-ACA as raw material to produce antibiotics requires multi-step chemical reaction and repeated separation and purification, and finally the purity of antibiotic drugs can be achieved. Scientifically speaking, the nutritional source of microorganisms is basically not directly related to the quality of 7-ACA, the quality of related drugs and the health of drug addicts.
The function of culture medium is to provide nutrition for the normal growth of microorganisms, and the target product of fermentation is the secretion of microorganisms, so the quality standard of culture medium can only meet the requirements of normal growth of microorganisms. Generally speaking, the culture medium is the food of microorganisms, and their control standards are definitely not as good as human food. Therefore, the quality of industrial microbial culture medium can only meet the requirements of national industrial microbial culture medium, and it is not necessary to be based on human food standards.
Drug safety is closely related to human health, and drug production is a complex chain. We should strictly control every link in the production process to ensure the safety of people's medication. However, different links should have different quality standards, and all links should not be required by other high standards, which will seriously waste social resources and reduce the competitiveness of products, which is extremely unfavorable to the benign development of ethnic medicine industry.