According to the scientific basis of combining work and rest, all activities should be completed by a healthy body. Now people pay more and more attention to the lifestyle of combining work and rest. Good health is the foundation of our life. The following is the scientific basis for combining work and rest.
The scientific basis of the combination of work and rest 1 the combination of work and rest has a scientific basis. "Too hard" cells can cause cancer, but restoring the biological clock can inhibit cancer. Like human beings, cells also have a "biological clock", which regulates the high and low expressions of various protein according to the natural "day and night alternation" cycle, thus controlling metabolism. Surprisingly, however, cancer cells are working overtime in secret, which can consume a lot of nutrients regardless of the circadian rhythm and accelerate their expansion.
Recently, a research report entitled "Restoring molecular clock has tumor inhibitory effect on neuroblastoma" was published in Nature Communication, which revealed the key mechanism of circadian rhythm disorder of cancer cells.
Researchers at Baylor Medical College pointed out that at least in neuroblastoma (NB), MYCN oncogene discovered earlier opened a "back door" for cancer cells. Overexpression of such genes can increase biological clock inhibitors, thus destroying the circadian rhythm and making cancer cells become "workaholics" successfully. If the activator is used to restore the cellular biological clock, it will inhibit tumor growth and make patients more sensitive to conventional chemotherapy.
Transcription factor BMAL 1 is the main driving factor of mammalian molecular clock, which regulates the expression level day and night alternately, thus regulating the orderly expression of downstream genes. Retinoic acid receptor-related orphan receptor α(RORα) and nuclear receptor REV-ERBα are the activation and inhibition factors of BMAL 1 respectively.
In this experiment, the researchers used the gene sequencing data of three groups of neuroblastoma (NB) patients with overexpression of MYCN gene to explore the mechanism behind the regulation of cellular biological clock by MYCN oncogene.
Among more than 1,000 patients with 1000, NB patients with high expression of RORα and BMAL 1, that is, patients with normal biological clock, have better clinical outcome, while patients with over-expression of biological clock inhibitor REV-ERBα have generally poor clinical outcome. In addition, when MYCN gene is overexpressed, the expression levels of RORα and BMAL 1 are inhibited, the biological clock is destroyed, and patients face worse clinical results.
Does this mean that MYCN can change the expression of circadian rhythm related genes? To test this hypothesis, the researchers examined the expression levels of RORα and REV-ERBα in MYCN overexpression and silencing. It was found that when MYCN was overexpressed, the expression of REV-ERBα was significantly up-regulated, while the expression of RORα and BMAL 1 was significantly down-regulated. When MYCN gene is silenced, the situation is just the opposite. In addition, enhancing the activity of RORα can make the inhibited biological clock return to the right track.
These data show that MYCN weakens the influence of circadian rhythm by regulating the down-regulation of RORα expression, and the imbalance of circadian rhythm affects the therapeutic effect of cancer. In this case, can restoring circadian rhythm inhibit the development of cancer?
Researchers treated MYCN overexpressed cells with RORα activator SR 1078 and found that cell growth almost stopped. RNA sequencing results showed that the activation of RORα restored the expression of BMAL 1 and restricted the expression of adipogenic genes, thus inhibiting the survival of NB cells. This result was confirmed in mouse model, and the recovery of BMAL 1 expression inhibited the growth of tumor.
It is worth noting that the recovery of biological clock not only limits the growth of tumor, but also improves the sensitivity of cancer cells to chemotherapy drugs. If SR 1078 is combined with conventional chemotherapy drug etoposide (VP 16), the cancer cells that were originally insensitive to VP 16 in xenotransplantation mice will accelerate apoptosis, indicating that regulating the molecular biological clock may be a feasible cancer treatment method.
In fact, as early as 20 15, a study in Cell Metabolism suggested that cancer cells could not follow the biological clock because a group of oncogene MYC genes discovered earlier opened the "back door" and destroyed cell metabolism and circadian rhythm. In this new article, the researchers further revealed the function of MYCn gene in myc family protein in regulating biological clock, and explored the method of restoring biological clock.
"The strategy of restoring the expression of BMAL 1 has prevented the growth of tumor, which indicates that inhibiting the molecular biological clock can indeed lead to cancer," said Dr. Evelyn Barbieri, assistant professor of pediatric hematology oncology at Baylor Medical College. "If we can develop clinically available drugs to restore the biological clock, it may increase the power of cancer treatment and drug resistance."
Scientific basis of combining work and rest. Combine work and rest, study hard and have a good rest.
Sleep is an important manifestation of human life movement. It is not advisable to reduce sleep and prolong study time. In the end, it may not be worth the loss.
Speaking of sleep, some people will advocate reducing sleep time in order to have more time to work.
Scientists disagree with this view. Pierre, a scientist, said, "You don't have to sacrifice sleep to be a genius." For a few people who have a particularly vigorous experience, it may be feasible to moderately reduce sleep time, but it is not suitable for most people. In any case, irreversible physiological characteristics.
Generally speaking, children and teenagers must get enough sleep for 8 hours every day to meet the needs of physical development; Adults are slightly reduced and must sleep for about 6 hours a day; Old people can sleep for 4-5 hours every day. It is precisely because of the different physiological characteristics that the elderly seldom sleep late at ordinary times, and almost all children fall in love with the bed.
The method of reducing sleep time has limited effect. The most important thing is to start from sleep itself and see how to improve sleep quality in these hours.
Everyone has a biological clock, which will not change easily in his life, so it is necessary to understand his sleep cycle. Finding out the exact duration of the cycle can make better use of time.
Pierre's calculation method is this: people will feel tired and weak at regular time every day.
Write down the time when you feel tired and the time difference between the two fatigue periods in a week, so that you will find that the fatigue period occurs almost at the same time every day, and the time difference between the two fatigue periods is basically the same.
Find your own sleep cycle. You can actively plan your sleep time during the sleep cycle and never use it for sleep during the intermission. This is your own efficient learning period. This will not only make sleep more comfortable, but also fully restore physical strength and energy.
Reasonable arrangement of sleep time can greatly improve the learning efficiency of non-sleep time and save time in practical effect.
Scientific basis of combining work and rest. Work and life should be combined with rest.
Excessive tension and busyness or excessive comfort are not conducive to our physical and mental health, nor to the development of work. The best working condition is "taking time off from work and being nervous during leisure".
Learning to relax in busy work and enjoying the fun of relaxing life is an art, which can bring you a higher quality of life and higher work results. When you realize that you are under too much pressure because of busy work, you must learn to lower your blood pressure. For example, if you do a good job in planning and planning, your pressure will be much less; Taking part in physical exercise at ordinary times, improving physical resistance and keeping energetic at all times are all effective ways to reduce work pressure.
Of course, we should also avoid excessive comfort, otherwise it will make us slack off and be very unfavorable to our work. When you are free, take a good rest first and prepare for the next work. You can also go to the library to read books and improve yourself to meet various challenges in your work. Believe a word: the opportunity always belongs to those who are prepared at ordinary times.
Write down or say how you feel about your job. This is your last suggestion. If you really feel that work has brought you great unhappiness, please write down or tell your feelings. After all, we have to admit that modern work does face a lot of pressure and many things that are not smooth. On the one hand, the competition is too fierce, on the other hand, the society is changing too fast. More often, stress is also beneficial, but it should be noted that stress can not be transformed into negative emotions such as complaints and depression, but should be transformed into motivation for progress.
We say that people should not complain, but it is beneficial to express their pain under great pressure. However, when we calm down, don't be disturbed by the reasons for complaining and let ourselves go. Of course, be tolerant when dealing with things.
There are many ways to vent, for example, you can find someone to talk to, talk about your worries, so that your mood can be relieved and people can relax. Don't let yourself be overwhelmed.
In addition, you can achieve this goal through self-reflection. For example, you can ask yourself: What if the work is not finished? What should I do if I can't do this thing well? For a positive person, asking yourself this question can make you prepare for the worst and be psychologically calm. Writing down your worries is also a way to relieve stress, such as keeping a diary and so on.