Decrease in oxygen saturation, what are the possible causes:
1, right shift, the reason for the right shift: decrease in pH, increase in partial pressure of carbon dioxide, increase in temperature.
2. Elevated 3DPG.
Implication of right shift in curve: lower affinity of Hb for oxygen. (For the same partial pressure of oxygen, a right-shifted curve corresponds to a smaller oxygen saturation of Hb, i.e., a lower affinity.)
The oxygen dissociation curve is a curve that shows the relationship between the partial pressure of oxygen and the oxygen saturation of Hb. The curve is similar to an "S" shape, and can be divided into the upper, middle, and lower sections.
Expanded Information
The significance of partial pressure of oxygen:
Tissue hypoxia due to insufficient supply of oxygen or obstacles to ventilation and gas exchange in the lungs; due to the patient's anemia, hemoglobin decreases, and the oxygen carried by the blood decreases;
Due to cardiac failure, shock, etc., the blood circulation is stagnant, and the blood flowing through the tissues is insufficient. Insufficient volume leads to tissue hypoxia; in severe acidosis and alcoholism, the tissues utilize less oxygen; in carbon monoxide poisoning and methemoglobinemia, the ability of hemoglobin and oxygen to right-synthesize is reduced.
Blood oxygen saturation and blood oxygen content is the blood oxygen saturation refers to the amount of hemoglobin with the combination of oxygen as a percentage of the total amount of hemoglobin, the blood oxygen content is the total amount of oxygen dissolved in the blood and hemoglobin combined oxygen, the two together with the partial pressure of the blood oxygen can be applied to determine the degree of tissue hypoxia and respiratory function.
Baidu Encyclopedia - Oxygen Saturation
Baidu Encyclopedia - Oxygen Dissociation Curve