Parkinson’s disease (PD) is a progressive neurological disorder that is a degenerative disease of the nervous system. Symptoms begin gradually, sometimes with only a slight tremor in one hand. The incidence of Parkinson's disease continues to increase around the world, with high disability and mortality rates, which seriously affects the quality of life of patients and places a heavy burden on families and society. The main purpose of current treatment for Parkinson's disease is to relieve symptoms and achieve a normal life. For Patkinson's treatment, doctors ultimately rely on the hospital, and no matter how good the doctor is, he cannot do without the hospital.
Parkinson’s disease is a disease of the central nervous system. Its treatment is mainly drug therapy and non-drug therapy. Drug therapy is the first choice and is the main method throughout the entire treatment process. Among them, levodopa is still the "gold standard" for the treatment of PD symptoms:
● Compared with other oral drugs, levodopa is more effective in treating PD
For most PD patients Response to levodopa treatment;
is also often used as one of the diagnostic criteria for PD.
● Levodopa has similar adverse reactions to dopamine receptor agonists, reflecting the level of dopamine stimulation
● Levodopa has 50 years of clinical use experience and has treated millions of patients. Benefits
For Parkinson's disease, neurology mainly uses drugs to treat Parkinson's disease. According to the clinical disciplines of Peking University, the evaluation and release of China's best clinical discipline evaluation rankings, among which the ranking of neurology hospitals is as follows:
However, as the disease progresses, the duration of action of a single dose of levodopa shortens, which is related to the continued degradation of dopaminergic energy, changes in levodopa/dopamine reserves, increased striatal pulse-like stimulation, and surge levels. The control of dopaminergic neurotransmission is less dependent. Therefore, non-drug treatment has become a new idea for the treatment of Parkinson's disease. Non-drug treatment mainly includes transcranial magnetic stimulation, deep brain stimulation, and mobile medical treatment.
1. Transcranial Magnetic Stimulation (TMS)
The treatment targets used for PD include the cortical main motor area (M1), the supplementary motor area (SMA), and the dorsolateral prefrontal cortex. District (DLPEC). Studies have shown that TMS treatment can improve the motor symptoms of PD patients and is safe.
2. Deep brain stimulation (DBS)
DBS therapy can continuously and effectively control the symptoms of movement disorders and improve patients' daily living abilities through long-term electrical stimulation of the brain's motor nuclei. , improve the quality of life. The 2014 American Lasko Medical Award was awarded to Professor Benabid, who invented the DBS device, and Professor Delong, who elucidated the mechanism of DBS treatment of PD. DBS technology is increasingly recognized.
3. Mobile medical treatment
Based on scientific and technological monitoring (TOMs), professional doctors can monitor and collect the daily motor symptoms of PD patients. In recent years, TOMs have turned to research on using wearable devices so that doctors can remotely monitor changes in patients' conditions at home.
Non-drug treatment is mainly a method commonly used in neurosurgery hospitals, and the ranking of neurosurgical diseases is slightly different:
? The best hospital for Parkinson's disease in the world
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For Parkinson's disease, Germany's Hannover Medical School (MHH) is very well-known for its treatment. MHH (Hannover Medical School) was founded in 1965 and is a world-leading medical center and regional medical center. center. The annual scientific research funding received by Hannover Medical School has always ranked first among German medical schools, and it is one of the most research-intensive schools in German universities. The medical major ranks third in Germany, behind Heidelberg University and Munich University. Hannover Medical School is a well-known independent medical school in Germany, the other is Lübeck Medical University.
Professor Joachim K. Krauss of the Hannover Medical School (MHH) in Germany is particularly good at the treatment of Parkinson's disease. He is one of the world-renowned professors who is very good at treating Parkinson's disease. Professor Joachim K. Krauss and France Professor Coubes improved deep brain stimulation (DBS) in the late 1990s and pioneered its use in the treatment of dystonia. The professor also won the German Oppenheim Prize for Dystonia in 2002 for his contribution.