(1) API equipment and machinery;
(2) preparation machinery;
(3) pharmaceutical crushing machinery;
(4) tablet machinery;
(5) pharmaceutical water equipment;
(6) pharmaceutical packaging machinery;
(7) drug testing equipment;
(8) other Pharmaceutical machinery and equipment (pharmaceutical auxiliary equipment)
1, pharmaceutical equipment according to the form of production can be divided into which two? Pharmaceutical equipment is divided into two forms:
1, single production
※ by the operator articulation and transportation of materials, production scale can be large or small, more flexible, but low production efficiency. (Tablet press,
High efficiency coating machine)
2, linkage production line
Larger scale of production, high efficiency, but the operation and raw material requirements are high, a failure will affect the entire linkage production. (Aqua needle washing, drying, filling and sealing linkage system)
2, pharmaceutical equipment, three-level maintenance or four-level maintenance, the cycle of maintenance at all levels and the person in charge. Equipment three-level maintenance rules 1, daily cleaning and maintenance
period: every day or every shift Responsible person: operator 2, the first level of maintenance
period: monthly, quarterly or semiannually
Responsible person: the operator (equipment officer, maintenance staff guidance) 3, the second level of maintenance cycle: every year
Responsible person: maintenance staff (operator to participate)
☆☆Some companies will be divided into four levels of equipment maintenance: routine maintenance, minor repairs (1-3 months), medium repair (3-6 months), major repairs (1-3 years)
1, the definition and composition of machinery
Definition of machine: used to transform energy or transfer of energy, materials, and information to perform mechanical movement of the device. The composition of the machine: 1 power part 2 executive part 3 transmission part 4 control part 2, pharmaceutical equipment commonly used materials which metals can be divided into: ferrous metals (iron and steel), non-ferrous metals (aluminum, copper and titanium and its alloys) non-metallic materials can be divided into: polymer materials, engineering ceramics, composite materials, 3, the use of the performance of the material mainly refers to those Mechanical properties, physical properties, chemical properties, 5, the common lubrication of the machinery What are the common lubrication methods for machinery?
Manual oil lubrication, drip lubrication, oil bath lubrication and splash lubrication, oil ring lubrication, pressure cycle lubrication 6, steel and cast iron with the difference between the composition of the
Industrial cast iron is generally 2% to 4% carbon content. Steel is 0.04%-2.3% carbon content
1, the main crushing forces are?
Impact, extrusion, grinding, splitting, shearing
2, universal crusher, hammer mill, ball mill rely on what force to crush materials?
Universal pulverizer: impact grinding shear hammer mill: impact shear ball mill: impact grinding 3, universal pulverizer safety operation points?
First lubricate the bearings before starting the machine to check the integrity of the pull to the belt to turn to the smooth start-up idling, to confirm the normal and then feeding, feeding to be uniform, do not add more than the hand or the machine should not be reached into the machine operators can not leave the post, found abnormal sounds immediately shut down the machine to check
4, Chaitian crusher in the role of the baffle
Control of the drug coarseness and crushing speed
Control of the drug coarseness and crushing speed
5, Colloid Mill: impact grinding Shear: ball mill: grinding p>5, the scope of application of the colloid mill, how to control the fineness of grinding
Solid crushing suspension emulsion preparation Principle: the use of high-speed rotation of the stator and the rotor can be adjusted gap between the material by a strong shear, friction and high-frequency vibration, etc. Crushing fineness control: adjust the distance between the stator and the rotor
6, the use of the ball mill and the characteristics of the air flow mill
Ball Mill p>Ball mill: closed operation to prevent dust flying to prevent the soaking of moisture to prevent the volatilization of drugs Air flow pulverizer principle: compressed air through the nozzle, the formation of high-speed airflow, resulting in a huge kinetic energy driven by the collision of materials with each other and crushed Characteristics: compressed gas through the nozzle when the nozzle sprayed expansion of cooling effect, so that crushing is carried out at low temperatures
1, sieve screen according to the different methods of production classification and use
woven sieve (dense mesh) punched sieve (more durable) 2, the specifications of commonly used medicine sieve
*** divided into nine, the larger the sieve number, the smaller the inner diameter of the sieve holes 3, the definition of mesh
number of mesh holes per inch of length
4, mixing equipment according to the classification of whether or not the container is rotated by the classification of the nature of the material mixture
according to the form of movement of the container is divided into: return to form, fixed type Fixed According to the nature of the material is divided into: wet and dry machine, wet mixing machine Mixing equipment are intermittent operation 5, the transformation of the types of mixing equipment
Rotary mixer (one-dimensional movement mixer): up and down turning two-dimensional movement mixer: self-rotating, rotating cylinder with the swing swinging frame swinging three-dimensional movement machine: the container for the radial, axial circular movement 6, commonly used fixed-type mixing machine equipment which
Trough Mixer double screw conical mixer gravity mixer flow mixer rotary disc mixer 7, the working principle of the tank mixer
The horizontal groove of the ∽-type screw belt low-speed rotation of the material from the ends to the center, and from the center to the ends, the material is constantly in the groove up and down and mixing uniformly.
1, the classification of fluid conveying equipment
Centrifugal reciprocating rotary fluid-acting
2, centrifugal pumps, impeller classification, various impellers suitable for conveying that type of liquid
Impeller pump casing Shaft shaft Shaft seals (packing) Impeller open (low effectiveness) Semi-open (suitable for conveying easy to precipitate or granular liquids) Closed (high efficiency, difficult to clean)
2, the centrifugal pumps, impellers, impellers, pumps, pumps, pumps, pumps, pumps, pumps, pumps, pumps and pumps. /p>
3, start the operation of the pump what attention
1. check whether the rotating part of the pump is flexible 2. filling the pump exhaust 3. close the vacuum gauge, manometer, pressure valve, outlet valve 4. Start the centrifugal pump 5. run smoothly open the pressure gauge, vacuum gauge , after observing no abnormality, slowly open the outlet valve 6. adjust the working parameters (pressure parameters) Conveyance is complete shut off the outlet valve, shut off the vacuum gauge, pressure gauge, stop the pump 4, centrifugal pumps produce the cause of vapor corrosion, how to avoid the vapor corrosion
Low pressure area liquid produces saturated vapor pressure. High pressure area bubble rupture, the surrounding liquid quickly rushed into the bubble space, the impeller. Pump casing produces a large instantaneous local impact 5, rotary pump types
Gear pumps, screw pumps
6, gear pumps and screw pumps are suitable for conveying those liquids
Principle of gear pumps: inlet at the two gears out of mesh, the formation of low-pressure suction of the material, discharged from two gears meshing with each other to form a high-pressure extrusion of liquid. Suitable for high viscosity liquid or paste materials, but not suitable for solid particles of the suspension
Screw pump principle: the internal thread, screw and screw mesh will be the liquid axial propulsion. Finally discharged Suitable for conveying viscous liquids
7, peristaltic pump characteristics
Principle: through the rotating rollers to make the hose peristaltic to transport the liquid Not in contact with the liquid, to avoid liquid contamination of the pump body Suitable for sensitive, viscous, highly corrosive, high purity requirements, containing a certain amount of particles of the material
1, classification of ventilators
Axial flow and centrifugal type Axial and centrifugal type is suitable for workshop ventilation centrifugal type is suitable for air conditioning system air supply device 2. Roots blower mechanism composition housing, waist rotor or triangular rotor working principle: the rotor rotates in the opposite direction so that the shell to form a low-pressure and high-pressure area
3, the types of compressors centrifugal reciprocating 4, vacuum pump classification
Reciprocating (for dry, not suitable for pumping gas containing more condensable vapors) rotary pumps, the vacuum pumps are classified
Reciprocating (for dry, should not pumping gas containing more (condensable vapor gas) rotary vane water ring (suitable for pumping corrosive flammable and explosive gases. (Not easy to danger) Jet type (pumping corrosive gases or toxic gases) 5, list the types of commonly used valves
By driving force (automatic valves, drive valves) By structure (gate-shaped, gate-shaped, plug-shaped and spherical, butterfly) By purpose (open and close valves, check valves, regulating valves, distribution valves, safety valves, traps, venting valves, sewage valves) 6, diaphragm valves, the characteristics
Easy to clean, suitable for injecting water, water, water and other materials. Diaphragm valve is easy to clean, suitable for the delivery of water for injection Diaphragm above the valve stem and other parts are not subject to corrosion, do not need packing seal, the media will not leak Diaphragm is a wearing parts should be replaced periodically depending on the medium by the media is limited to low-pressure and relatively low-temperature occasions
1, what are the commonly used filter aids
Diatomaceous earth activated carbon, perlite, asbestos
2, the classification, characteristics and scope of application of the vertical melting glass filter
2, the classification, characteristics and scope of application of the glass filter Classification, Characteristics and Scope of Application
Funnel, Filter Ball, Filter Rod Characteristics: Sintered from hard glass, chemically stable, small adsorption effect on the drug solution, no chemical interaction with the drug solution, does not affect the pH value, easy to wash, can be hot-pressing sterilization. Used for fine filtration or preheating before the membrane 3, those filtration equipment can only be coarse filtration, those filtration equipment can be fine filtration
Crude filtration: plate and frame filter press sand filter rods can be used as fine filtration: pendant glass filters 4, the classification of microporous membrane components
plate and frame, tube, roll, hollow fiber type
1, listing the components of the multifunctional extraction tank
Tank body Fork (moving up and down to turn the medicine) feeding port jacket device sieve plate (slag) discharge port 2, the advantages of multi-stage countercurrent extraction
Saving solvent, saving energy to improve the rate of active ingredients 3, supercritical extraction of common solvents
CO2 (non-toxic, odorless, non-corrosive, easy to recycle) 4, supercritical extraction process of the main equipment
Solvent storage tank Extraction kettle Separation kettle Compressor pressure reducing valve solvent circulation pump refrigeration unit
1, multi-effect evaporation and single-effect evaporation, what are the advantages
Single-effect evaporation evaporation evaporation, heat transfer area is large, but multi-effect evaporation: increase the number of effects can save energy, but the more the number of effects of the larger the investment cost of the equipment
2, multi-effect evaporation of the process
parallel flow against the current, advection
3, Circulating evaporator and single program evaporator in the use of the difference
Single program evaporator: suitable for heat-sensitive materials Circulating evaporator: liquid circulation fast, evaporation rate is high 4, evaporator defoamer device and the role of the "atmospheric leg"
Defoamer device: separation of liquid droplets and spray foam, reduce losses Atmospheric leg: Atmospheric leg: prevent the condenser below the role of atmospheric pressure into the water
1, dry bulb temperature, wet bulb temperature measurement and its relationship with the relative humidity
The greater the difference between the dry bulb temperature and the wet bulb temperature, indicating that the lower the relative humidity 2, the drying process can be divided into that several stages? Characteristics of each stage
Preheating Constant speed drying Reduced speed drying 3, drying equipment, energy-saving measures
Wet material pretreatment (as much as possible before drying to remove moisture in the material) Adoption of lower exhaust gas outlet temperature and higher humidity operating conditions will be recycled (but will reduce the impetus) will be the exhaust gas before the exhaust gas exhaust into the preheater to heat up the cold air pay attention to the warmth of the equipment and piping
4, which kinds of heat source of tunnel dryer
Electric steam far infrared microwave
5, the operation of boiling drying precautions First open the fan, then heating First off the heating, to be close to the temperature of the air temperature at room temperature, and then shut off the fan Close the fan for about 1min before the bag can be pressed to shake the bag device, to prevent the bag from tearing To be sealed after the depression, you can pull out the boils unloading 6, the atomizer of the spray dryer atomizer Types of spray dryer atomizer
Airflow type pressure type centrifugal type
7, spray drying in the droplets relative to the flow of air in several ways
Across the stream: drying the material temperature is not high, the product is often a non-spherical particles, the texture of the looser Mixed flow: stay a long time, for high temperature materials countercurrent: high thermal efficiency, suitable for non-heat-sensitive materials
1, the role of distillation, the distillation of the classification
1, the role of steam, distillation Classification
Distillation: based on the volatility of the components have different separation process Distillation (multiple distillers in series): for high separation can be divided into: plate tower, packed tower 2, the pharmaceutical industry in the types of process water
Drinking water (tap water) Purified water Water Water for Injection Sterilization of water for injection, 3, purified water preparation methods and their advantages and disadvantages
Ion exchange method (advantages and disadvantages)
Ion exchange method (advantages, disadvantages, and disadvantages, applicable to non-thermal sensitive materials)
Ion exchange method (advantage: high rate of salt removal) Disadvantage: resin regeneration consumes a large amount of concentrated hydrochloric acid and sodium hydroxide, resulting in higher water production costs, pollution of the environment) distillation method electrodialysis method (power consumption, salt removal rate is not high, only for the primary desalination of the pure water production process) reverse osmosis (bacteria, pyrogens, viruses, and the removal of organic matter up to 100%, but the desalination rate of 90%, the high salt content requirements of raw water) electrodes to remove the salt content of the raw water, and the water is used as the raw material to remove the salt content of the raw material. Ion exchange membrane is divided into how many types
Can be divided into: frame type tubular rolled hollow fiber type
5, ionization ionization method is a combination of those two water production methods, divided into how many processes
Electrodialysis + Ion exchange When the raw water enters the DC field, ion migration, ion exchange
Ion migration, ion exchange, ion exchange, ion exchange, ion migration, ion exchange, ion exchange, ion migration, ion exchange, ion exchange, ion exchange, ion exchange, ion exchange, ion exchange, ion exchange, ion exchange, ion exchange, ion exchange and ion exchange. Ion migration, ion exchange
1, physical sterilization and chemical sterilization methods include what
Physical sterilization (dry heat, moist heat, radiation, filtration) Chemical sterilization (gas sterilization, chemical sterilization) 2, the meaning of the FO value
A certain temperature sterilization temperature Z for 10 ℃ produced by the sterilization effect of 121 ℃ Z for 10 ℃ produced by the sterilization effect of the same equivalent when The sterilization effect of a certain temperature sterilization temperature Z is 10 ℃ and 121 ℃ Z is 10 ℃ produced by the sterilization effect of the same equivalent time.
3, steam sterilization equipment verification of specific items and judgment criteria
Instrumentation calibration heat distributor test heat penetration test bio-indicator validation test 4, sterilization equipment need to be re-validated
Change of prescription, sterilization process sterilization equipment; generally done once a year in the validation of the 5, the operation of high-pressure steam sterilizers
Open steam valve, open the exhaust valve Pre-sterilization of the steam valve, open the exhaust valve. Steam valve, open the exhaust valve Preheating 10-15min (Fly, when there is no foggy water droplets in the exhaust hole is to close the exhaust valve) Heating to close to the temperature, adjust the exhaust valve to maintain the sterilization temperature. After reaching the sterilization time, close the inlet valve, gradually open the exhaust valve, the table pressure drops to zero after slightly opening the cabinet door, 10min after opening the cabinet door out of the material. Sterilization time from all the liquid to reach the sterilization temperature when counted after sterilization is completed, it is strictly prohibited to open the cabinet door immediately to prevent the pressure difference and the temperature difference is too large to burst bottles and injuries
6, the advantages of the water bath type sterilizer
Relying on the circulating water (deionized water) to indirectly lower the temperature to reduce the burst bottles. Burst bag phenomenon to avoid the cooling process after sterilization due to the cooling water is not clean, resulting in secondary pollution
7, according to the sterilization process, the tunnel dry sterilization machine is divided into several parts of the interior
Preheating part of the high-temperature sterilization part (300 ℃ -350 ℃) Cooling part of the comparison of the two tunnel-type dry heat sterilization characteristics
Hot air circulation tunnel dry heat sterilization Machine: uniform heat sterilization effect is good; but the high efficiency filter must be resistant to high temperature, the price is high Radiation dry heat sterilization machine: no hot air circulation in the high temperature sterilization area, the material on both sides of the tunnel is not uniformly heated, the sterilization effect is a little worse; but do not need to set up a high temperature resistant high efficiency filters, the cost is low.
1, according to the nature of the equipment, the method of making granules, there are several kinds of
Granulation method: wet granulation dry granulation Boiling dry granulation method 2, commonly used wet granulation equipment which
Swinging granules Rotary granulator Rapid mixing machine
3, the working principle of the swinging granule machine, factors affecting the quality of particles
The use of rack and pinion mechanism, so that the roller reciprocating rotation, the soft material from the sieve mesh forced out, imitating the artificial in the sieve mesh by hand rubbing sub. It can make wet granules or whole granules The influencing factors of granule quality: the diameter of the sieve holes the stock of soft materials in the hopper and the tightness of the installed sieve mesh The binder concentration is high, the dosage is large, and the number of times it passes through the sieve is large; the granules are even and solid 4. The working principle and operation flow of the rapid mixing and granulating machine
The stirring paddles make the materials in the granulating cylinder flip up and down and turn around quickly and uniformly, and the mixture is cut under the cutting of the high-speed rotary granulation knife, and then cut into wet granules. The mixture is cut into wet particles operation: check before starting disinfection feeding mixing (stirring paddle) soft material (spray binder) granulation (granulation knife) discharge
5, the working principle of the boiling granulator, why also known as one-step granulation
Principle: the material powder by the purification of the role of the hot air, in the fluidized bed in the fluidized state, and into the preheating and mixing, atomization of sprayed into the binder, the particle Aggregation into granules, due to the hot air on the material is constantly drying, the water in the granules evaporate, forming uniform porous spherical particles because it will be mixed, granulation, drying three steps in one
6, the role of compressed air in the Boiling Granulator
The role of the compressed air: the formation of the spray pressure of the spray gun to control the switch of the gun to control the lifting of the piston to control the pulse valve to control the alternating blowback jitter filter bag < /p>
7, boiling granulator gun installation position and purpose
Top spray: to avoid the material will be clogged gun (granulation, coating) bottom spray: so that the heart of the tablets wet and uniform (coating) Tangent spray: gun mounted on the wall of the container (pills, granulation, coating)
1, multi-stroke rotary tableting machine general structure (five parts) feeding part, tablet part of the composition
Feeding part, tablet part
The tablet part, tablet part suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction, suction. >Charging part of the tablet part of the suction part of the control part of the power and transmission part of the 2, the role of the moon shaped reflux grille feeder
filling, quantitative discharge of tablets
3, multi-punch rotary tablet press of the three working processes, as well as upward and downward stroke of the law of motion
Working process: the filling process, the pressing process, the process of the film upward stroke trajectory: parallel downward, upward, downward, and then upward, downward, and then upward. Punching process: downward and then upward, slightly downward and then upward, upward Tablet pressing process: filling, pressing, tablets out of tablets 4. What is the function of pre-pressure wheel
Pre-pressure and then loosening, so as to make the air escape and prevent from cracking. 5. What device is used to regulate the weight of the tablets and the hardness of tablets
Tablet weight regulating device, tablet thickness regulating device. 6. The structure and working principle of backfill regulating device
Principle: Change the filling thickness in the hole of lower die, and change the filling thickness in the hole of middle die. Principle: change the position of the lower punching bar in the hole of the middle die, so as to change the loading volume in the hole, so as to regulate the filling volume of the die hole (i.e. tablet weight) Structure: filling rail, screw, nut (outside worm gear), worm gear, handwheel. 7. Composition and working principle of the tablet thickness regulating device
Principle: change the position of the lower pressure wheel, so as to change the distance between the lower punching bar and the upper punching bar when the tablets are pressed, so as to regulate the thickness of the tablets, and the pressure (i.e. tablet hardness) is regulated as well. Structure: lower press wheel lower press wheel crankshaft worm worm wheel 8, What are the two common pressure overload protection
Pre-pressure overload protection Filling volume overload protection 9, Problems that may occur during pressing and how to deal with them
Check whether the die and the punch are broken or not before installing the punch before starting the machine and install the shield, and don't dismantle the shield during operation. Do not use, otherwise the lower punch leakage, accelerate the wear and tear of machine parts and loss of raw materials Water content exceeding the standard of raw materials can not be used, otherwise it will affect the fluidity of the particles and cause sticking punch The production process staff can not be away from their posts when dismantling and assembling molds can only be operated by one person When the production is about to end, should pay attention to the amount of residual material, close to the absence of material should be to reduce the speed of the car or shut down
1, types of coatings
Sugar coated films (gastrolysis, enteric coated, etc.), and the production process can not be used. Clothing (gastrointestinal coating, enteric coating) 2, commonly used coating equipment
coating pot spray coating machine high efficiency coating machine boiling spray coating machine 3, high efficiency coating machine composition
mainframe control system spraying system hot air cabinets exhaust cabinets stirring dosage system feeding and discharging device 4, high efficiency perforated coating machine working principle
sheet core in the rotating drum for turning movement, the coating medium through the peristaltic pump from the spray gun to sprinkle the coating medium, the coating medium through the peristaltic pump, the coating medium through the peristaltic pump to the coating machine. Peristaltic pump from the gun sprinkled to the piece of core, clean hot air through the piece of core from the bottom of the sieve hole discharge, the piece of core surface drying into a thin film 5, perforated coating machine and non-perforated coating machine on the difference between the use of the machine
Perforated: tablets. Coating of plastic pills Non-porous: small pills? The coating of dropping pills (using the air channel distributor exhaust to avoid the drug falling into the sieve hole
6, the focus of quality control in the coating operation
Mastering the relationship between the pot temperature, spraying speed, speed of rotation
7, coating liquid spraying speed, pot temperature and speed of rotation on the quality of coating
Spraying speed and the control of the temperature of the hot air: the surface of the tablets should be slightly wet, the temperature is too low or the spraying speed is too fast: the tablets are easy to stick the temperature is too low, the temperature is too low. : tablets are easy to stick Temperature is too high: too fast drying, film formation is rough. Tablet color is not uniform Control of pot speed: low speed: film adhesion is strong High speed: film adhesion is poor, easy to peel
1, syrup agent commonly used in the production of equipment which
Sugar dissolving filtering equipment (sugar dissolving pot filters) dosage equipment (liquid dispensing tanks, filters, storage tanks) Filling and sealing equipment 2, syrup agent filling equipment according to the different stations can be divided into which two
Can be divided into: Linear turntable type
3, syrup filling machine is mainly composed of those parts
Principle: the container through the bottle organizer through the bottle conveyor to the filling station plunger pump metering filling filling sent out of the filling machine by the bottle conveyor filling mechanism blocking the bottle power mechanism
1, the specifications of the hard capsule
000, 00 (veterinary use) 0,1,2,4,5 (human) 2, hard capsule filling process (7 steps)
Preparation process: empty capsule preparation Filling Sealing Polishing Packaging Crushing of raw materials Addition of excipients Mixing of granules
Filling process: empty capsule drop and powder supply Direction correction Cap separation Drug filling Striking waste Cap closure Capsule delivery
3, capsule directional arrangement has which two Steps
Horizontal correction Vertical correction
4, filling type filling automatic capsule filling machine has the two rotary disk, what are their respective roles
Capsule rotary disk: 12 or ten stations (to complete the capsule row direction, separation, ticking, closure, discharge, and other operations) Powder rotary disk: 6 stations (the punching rod will be the powder to fill the powder into the body of the capsule) 5, automatic capsule filling machine, the capsule rotary disk: 12 or 10 positions (complete capsule direction, separation, ticking, closure, discharge and other operations) The capsule rotary disk of the automatic capsule filling machine, 10 stations play a role
Spread capsule and capsule separation of the lower module quickly down and outward micro-pill filling pill column filling residual expansion of the station ticking waste under the module inward and upward locking the capsule discharged module cleanup
6, automatic capsule filling machine, the amount of medicine should be adjusted, the scale of the readings on behalf of what
Adjustment of the amount of medicine: Adjustment of the filling lever Into the depth of the dose (the deeper the greater the load) Scale reading: the distance between the lower plane of the filling lever and the lower plane of the dose tray
1, according to the preparation method of pills can be divided into several categories
according to the method of preparation: plastic pills, pan-fabricated pills, drops of pills, according to the excipient: water pills, honey pills, pudding pills, wax pills, concentrated pills, 2, plastic method of the preparation of pills in the block (soft materials) of the equipment
Kneading machine, trough mixer
3, plastic method of filling the pills in the capsule filling machine, the filling rod is not a good idea, but it is a good idea. /p>
3, the composition of the pill-making part of the automatic pill-making machine
Pill strips and two parts of the granulation, rounding Principle: the use of screw propellers will be extruded from the soft material from the circular holes on the strips, the formation of pill strips, the use of opposing knife wheel staggered back and forth movement, the pill will be rounded, the pill in the alcohol lubrication of the knife wheel out of the fall in the discharge chute 4, the pan-production system of pills using the equipment < /p>
coating pot Principle: fine powdered drugs by water (or wine, juice, liquid paste and other liquid binder) exchange wetting, spread in the machinery, tumbling layer by layer to increase 5, the composition of the drip pill production equipment (4 parts)
drip tube insulation device coolant temperature control device coolant containers Principle: the liquid and the substrate through the heating tank heating and mixing, by the drip tip into the condensate incompatible with the substrate Incompatible condensate, droplets in the surface tension of the force of contraction condensation into a spherical, driven by the coolant out of the outlet, collected through the screen 6, production factors affecting the quality of the drop
Pill weight: drop caliber (within a certain range of large diameter of the tube drop of pills is also large, and vice versa is small) Temperature (temperature increases, the viscosity decreases, the surface tension decreases, the weight of the pill is smaller) drop outlet and the coolant surface distance (distance is too large due to gravity, the coolant surface is too small) Distance (the distance is too large due to gravity is falling apart and produce fine particles, the distance between the two should not be more than 5cm) such as drop out of the coolant immersed in the drop system, the drop must overcome the buoyancy to drop, the weight of the pill will increase
Roundness: droplet speed in the coolant (the faster the speed, the greater the force, the flatter the shape) Adjustment method: reduce the difference in the density of the liquid and the coolant, improve the viscosity of the coolant) Droplet size (the ability of small pills to shrink into a ball, roundness is better than large pills) Coolant temperature (droplets cooled too quickly so that the pill is not round, resulting in hollow or drag the tail Adjustment: gradient cooling, so that the coolant temperature is gradually lowered (on the hot under the cold)) 7, Automatic Pill Making Machine
1, the pill type is not round (① pill knife is not the right way to make the right pill knife, re-rectification of the pill making knife. ② out of the strip and the pill knife does not match, replace the match. (③ powder is too coarse, re-crushing, micro-powder, to ensure that the fineness of the powder.)
2, out of the strip speed and cut the speed of the pill is not synchronized (self-control failure, the inductor switch and the self-control of the metal piece of the skewer is not in contact.) 3, out of the strip is not smooth (① heating ring is not heated, out of the strip piece of low temperature. ② multiple extrusion, so that the density of the drug strip increased). 4, the pill shape is cylindrical (out of the strip and the pill knife does not match, expand the strip hole).
5, the square box abnormal sound (① knife shaft and gear research injuries, oil shortage. ② bearing may be damaged.) 6, push the material leakage (replacement of PTFE pads.)