Helicobacter pylori is one of the most popular topics in the field of health science in the past two years, and through a series of popularization of H. pylori has attracted enough attention, and even a small-scale panic. Experts had to come out to continue to popularize: H. pylori is not so terrible, reasonable and proper treatment will not affect the health.
So in the end, the relationship between this bacterium and human beings is how, it is really a hundred harm and no good? Today is ready to give the subject and everyone to bring some cutting-edge information about Helicobacter pylori and expert *** knowledge, so that we can be more dialectical to look at Helicobacter pylori infection this problem, so as to avoid blind panic at the same time, but also timely detection of the problem, to ensure that the body's health.
Helicobacter pylori witnessed human migration tens of thousands of years ago, and it's not all bad. It has been reported in the literature that H. pylori has a high probability of originating in East Africa, where it began to spread outward from about 58,000 years ago.1,2 Based on the article's description, it can be concluded that about 50,000 to 70,000 years ago, H. pylori accompanied the migration of modern humans outward from Africa, witnessing a a mass migration in human history.By understanding this history, we can realize that H. pylori is not a recent phenomenon, and that it has accompanied human survival and development for tens of thousands of years. Then we naturally begin to think of a question, accompanied by our so many years of flora, free to get rid of whether it will cause the body of other adverse reactions? Is it really all harmful to the body?
At present, some researchers have begun to pay attention to this aspect of the study, and there has been initial progress: some studies have reported that the process of eradicating H. pylori by oral medication (mainly proton pump inhibitors, such as omeprazole, etc.) may cause disruption of the gastrointestinal flora and lead to an increase in the number of other pathogenic bacteria, which raises the risk of intestinal infections.3 At the same time, the study of whether it is also beneficial in the body is also being carried out feverishly. feverishly underway.
? H. pylori is a protective factor against some diseases, reducing the incidence of asthma and reflux esophagitis Researchers have confirmed, based on a variety of studies, that H. pylori is not always bad for the body, and that in addition to some negative effects when it is cleared, H. pylori itself may be a protective factor against some diseases.Wang Qiang from Tongji Hospital, affiliated with Huazhong University of Science and Technology (HUST), summarized the mechanism of H. pylori in preventing asthma in an article published in 2012, and through reading a large number of Chinese and foreign literatures, she put forward the viewpoint that H. pylori has a positive role in preventing asthma in children.4
The process of asthma attack in human beings involves two kinds of cells, Th-1 and Th-2, and we can simply understand that the Th-1 cell is the one that causes asthma, which is the most important cell in the human body, and that it is the one that causes asthma. We can simply understand that Th-1 suppresses asthma attacks and Th-2 vice versa. Infection with H. pylori in humans protects the body by enhancing the role of Th-1 cells and suppressing Th-2 cells, which promote asthma attacks, through a series of complex reactions.5,6,7 Studies have shown that infection with H. pylori at a young age can be effective in suppressing the development of asthma and other allergic diseases, and this is supported by published *Meta-analyses*.8
These studies have shown that H. pylori infection at a young age can be effective in suppressing the development of asthma and other allergic diseases.
Others have studied the relationship between H. pylori and reflux esophagitis, analyzing retrospectively 374 patients admitted over a 1-year period and comparing them, and found that patients with reflux esophagitis infected with H. pylori had a significantly lower rate of recurrence after cure than those who were H. pylori-negative, and the time to recurrence was significantly longer than that of the latter. Therefore, the authors concluded that H. pylori is a protective factor for reflux esophagitis.9 Similar studies have been done abroad, and the conclusions are basically the same.10 According to the analysis, the main reason is that the urease and other substances secreted by H. pylori can change the acidity and alkalinity of the stomach and at the same time antagonize the relaxation of the esophageal sphincter, which can avoid the damage caused by the reflux of gastric acid into the lower esophagus and play a preventive role in the attacks and recurrences of reflux esophagitis. It plays a preventive role in the attack and recurrence of reflux esophagitis.
Not only these benefits, but H. pylori has also been shown to have a positive effect on the prevention of pediatric obesity.11 Therefore, there has been an ongoing academic debate about whether H. pylori should be eradicated without discrimination.
Helicobacter pylori eradication is still a controllable means of preventing gastric cancer, and the timing and conditions of eradication are important. Although H. pylori appears to have some benefits for humans, the conclusions need to be refined through further research. What is known in the academic world, or what has been demonstrated by a large number of studies and literature, is that H. pylori is a class of carcinogens, and the eradication of H. pylori plays a definite role in preventing the occurrence of gastric cancer.Professor Sugano, a leading authority in the field, pointed out that eradication of Hp reduces the risk of gastric cancer by 54%, and that about 4.3% (480/11149) of the control group without Hp eradication developed gastric cancer in 10-15 years.12 Professor Liu Wenzhong of the Renji Hospital affiliated with the School of Medicine of the Shanghai Jiaotong University, in his interpretation of the "Kyoto **** Awareness Report on Hp Gastritis", also mentioned that, compared to the negative effects of the eradication, high levels of gastric cancer were observed in the control group, and the risk of gastric cancer was also high.
The development of gastric cancer is the result of multifactorial ****action, and a large number of studies have confirmed that H. pylori has a high probability of causing cancer in people with a family history of gastric cancer or gastric diseases (especially atrophic gastritis or gastric ulcers) and that failure to eradicate it will lead to a lot of trouble. Therefore, experts neither advocate indiscriminate eradication of H. pylori, but for high-risk groups, it is recommended to always follow the doctor's advice to actively deal with.
Research on H. pylori is still ongoing, and many conclusions need to be supported by more data, but at least with the current research we know that H. pylori does not cause harm, and that it is important to be more careful about the timing and conditions of its eradication.
Helicobacter pylori eradication has its own priorities, and the following groups of people need to focus on In summary, not all people in the detection of Helicobacter pylori infection should be blindly eradicated treatment, through the various types of literature, *** knowledge and diagnostic and therapeutic programs, it is recommended that the following groups of people to focus on and actively eradicate Helicobacter pylori:
1. People with gastric diseases such as chronic atrophic gastritis, peptic ulcer and MALT lymphoma;
2.? People with gastric cancer, post-gastric surgery or a relevant family history;
3.? People who plan to take proton pump inhibitors (omeprazole, etc.) or non-steroidal anti-inflammatory drugs (aspirin, etc.) for a long period of time;
4.? Others who have been diagnosed by a gastroenterologist and recommended aggressive radical treatment.
As for children and elderly or infected people without gastric symptoms, there is no need to be nervous and it is enough to keep an eye on your health.
Helicobacter pylori is a colony of bacteria that has existed with humans*** since ancient times, and its presence is not a demonic threat to people's daily lives. Some data show that more than half of our population is infected with H. pylori, but it is well known that the incidence of stomach cancer is much lower than this figure.
It is hoped that we do not talk about so-and-so, but rather learn about it through formal channels and look at the various problems associated with it dialectically. As with H. pylori infection, not everyone needs to be actively treated, nor can we just leave it alone, learn more about some of the relevant science, listen to the doctor's advice, in order to guard our own health and family happiness.
Nouns:*Meta analysis: Meta-analysis, also known as "Meta-analysis", is a comprehensive collection of literature on research topics from all over the world, and draws conclusions by analyzing big data. The conclusions drawn are more reliable than traditional statistical methods.
*Professor Sugano First author of the Hp Gastritis Kyoto*** Awareness Report
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2 Ma, J. (Translation). Karma that began 5.8 years ago - using Helicobacter pylori to infer the history of the great human migration J. Sci. World, 2007(6):87-87
3 ImhannF, BonderMJ, VichVilaA, etal. Proton pumpinhibitors affect the gutmicrobiomeJ.Gut, 2016, 65(5):740-748
4 Wang Q. Helicobacter pylori against the occurrence of asthma and its development mechanism[J]. Chinese Journal of Aesthetic Medicine, 2012, 21(8):237-238.
5 Codolo G, Mazzi P, Amedei A, et al. The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma [J]. Cell Microbiol. 2008, 10(11) 2355-63.
6 Mathias Oertli DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance,and asthma protection [J]. Clin Invest.2012,122(3):1082-1096.
7 Mike Tsz Hin Ng, et al. Increase in NF-k B Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9-1237T/C Polymorphism Is Associated with Helicobacter pylori-Induced Gastric DiseaseJ].Infect Immun. 2010, 3(78): 1345-1352.
8 Leah Mok. A meta-analysis of the correlation between Helicobacter pylori infection and the development of bronchial asthmaD
9 Xue, R. W.. Analysis of the correlation between Helicobacter pylori and recurrence rate of reflux esophagitis[J]. Modern Instrumentation and Medicine, 2015(6):28-29.
10? A liM A, AbdellatifA A. Prevention of sevoflurane related em ergence agitation in children undergoing adenotonsillectomy: a comparison ofdexmedetom idine andpropofol[J].SaudiJAnaesthe, 2013, 7(3):296-300.
11? Graham DY. Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits [J]. Gastroenterology 2015,148(4):719-731.e3.
12? Sugano K, Hiroi S, Yamaoka Y. Prevalence of Helicobacter pylori Infection in Asia: Remembrance of Things Past?[J]. Gastroenterology, 2017, 154(1):257.
13? Liu WZ. Interpretation of the "Helicobacter pylori gastritis Kyoto global **** knowledge"[J]. Gastroenterology, 2015(8):449-456.