A: In view of the short time of popularization and application of donor artificial insemination, it is difficult to make a comprehensive evaluation of the physical intelligence of donor artificial insemination infants. The existing follow-up results show that the development, physique and intelligence of artificial insemination babies are slightly better than the average level of babies born in natural population. Some people think that the intelligence and physique of infants who are artificially inseminated with frozen semen are better: the reason may be that semen freezing has the function of "selecting the best". In recent years, there have been detailed reports on the super intelligence of frozen donor artificial insemination babies abroad, but the number of follow-up visits is small, so it is difficult to explain the problem accurately. But generally speaking, human sperm banks have strict conditions when choosing sperm donors. Therefore, from the genetic point of view, the physical and intellectual conditions of artificial insemination babies may be better.
U Q: Is the cost of artificial insemination of husband's sperm high?
A: The cost of artificial insemination of husband's sperm varies from place to place and from hospital to hospital. The expenses include husband and wife's examination, ovulation monitoring and artificial insemination. Some even include the cost of semen washing and ovulation induction. It is estimated that the cost of each treatment is between 500- 1000. Of course, the earlier you succeed, the less you spend, but the patient should be prepared psychologically and economically for a course of treatment (6-8 cycles) that is unsuccessful, especially if the man's semen is abnormal.
U Q: What is the success rate of husband's sperm artificial insemination?
A: The success rate of artificial insemination depends on the following factors. First, the cause of infertility is very important. The success rate of artificial insemination is higher in men with good sperm quantity and vitality but unable to have sex than in men with abnormal sperm. Second, the woman's age also plays an important role. If the woman is over 35 years old, the probability of pregnancy is significantly reduced; Third, the predictability of ovulation is also very important. The more regular menstruation, the higher the success rate of pregnancy; Fourthly, endometriosis, pelvic infection or tubal diseases reduce the success rate, but those who have had a previous pregnancy history have a higher success rate.
In a word, in the monthly artificial insemination, the pregnancy success rate of each cycle is about 10% to 15%.
Q: What are the mental burdens of artificial insemination with husband's sperm?
A: The mental burden of husband's sperm artificial insemination is usually as follows: (1) The man may feel that he has lost his self-esteem; (2) The man may be worried about losing his wife due to infertility; (3) The woman may blame or lose her temper with the man because of infertility; (4) The woman may feel inferior or even despair; (5) Artificial insemination may make both husband and wife feel that someone will interfere with their sexual life, thus affecting their intimate relationship; (6) Once pregnant, worry about abortion and congenital malformation. If you encounter the above problems, you can consult a specialist or psychologist and the corresponding social organizations, or you can talk to someone with the same experience to relieve your psychological pressure.
U Q: Which is better for artificial insemination of vagina, cervical canal or uterine cavity?
A: Each of the three methods has its own indications, advantages and disadvantages, and it cannot be considered that one is better than the other. Intravaginal artificial insemination is closer to physiology, and the sperm is screened layer by layer, which achieves the effect of survival of the fittest and avoids the potential dangers such as bleeding and infection caused by the latter two. Once pregnant, the abortion rate and deformity rate are also lower than the latter two in theory. Intrauterine artificial insemination makes some sperm directly enter the cervical canal, which increases the chances of sperm entering the uterine cavity, thus increasing the chances of pregnancy. In practical application, the first two are often combined. That is, a part of sperm is injected into the cervical canal (because the capacity of the cervical canal is limited, generally around 0.3 ml). While the rest is placed on the cervix. Intrauterine artificial insemination is more suitable for severe oligozoospermia, cervical abnormality, abnormal interaction between sperm and cervical mucus, unexplained infertility, etc., but it is limited in practical application because of its potential risks such as bleeding, infection, abortion rate and deformity rate. In short, we must strictly control all indications.
U Q: How many times can I get pregnant after artificial insemination?
A: We know that normal people can't get pregnant as soon as they get married. According to statistics, healthy people and couples live a regular sex life without using contraceptive measures, and the pregnancy rate within half a year is 80%. Accordingly, 6-8 cycles (each cycle 1-2 artificial inseminations) are usually regarded as a course of artificial insemination at home and abroad. Because the ovulation period is specially selected during artificial insemination, as long as there is no abnormality in semen and female reproductive tract, the success rate should be higher than the natural pregnancy rate (more than 80% in half a year). If you are not pregnant after a course of treatment, don't do it blindly, but look for the reasons, and then carry out targeted artificial insemination or other methods.
Q: How many times should I do artificial insemination in January?
A: If you just catch up with ovulation, artificial insemination once is enough, and many times is also a waste, and there may be some interference (especially artificial insemination from different sources), but you can't determine the exact ovulation time. Clinically, you can only determine the ovulation period of one week, so it is feasible to conduct artificial insemination once or twice a month in practical work.
Q: When is artificial insemination?
A: Theoretically, artificial insemination should be performed during ovulation. But at present, there is no accurate method to determine the ovulation time. After ovulation, the fertilization ability can be maintained for 24 hours and the sperm can be maintained for 48 hours. Therefore, artificial insemination can be carried out during ovulation (easy pregnancy), which is equivalent to three days before ovulation and one day after ovulation. Clinically, ovulation can be judged according to the change of basal body temperature, LH peak, ovulation monitored by B-ultrasound and the change of cervical mucus.
U q: who is suitable for artificial insemination?
Answer: Suitable for artificial insemination: (1) incurable azoospermia or severe oligozoospermia; (2) The man has a genetic disease; (3) If the woman is Rh negative and the man is Rh positive, and both husband and wife have given birth to children with congenital anemia, the semen of Rh negative donors should be used; (4) The husband's artificial insemination failed repeatedly for a long time and the reason could not be found.
Q: What tests should the man do before artificial insemination?
A: Before artificial insemination with husband's sperm, it should be clear whether the cause of infertility is suitable for this treatment, including whether the man's semen is suitable. The doctor will ask the medical history of both husband and wife in detail and conduct a comprehensive physical examination of the man. The doctor will ask the man to provide several semen for analysis or other tests, such as sperm antibody test and sperm motility test, and may also check the man for human immunodeficiency virus (HIV), hepatitis B and hepatitis C virus and sexually transmitted diseases.
Q: What kind of examination should a woman have before artificial insemination?
A: The woman's examination includes a detailed medical history, a comprehensive physical examination, focusing on pelvic examination, as well as the examination of hepatitis B and hepatitis C virus, human immunodeficiency virus, rubella virus and other diseases. It is also important to determine the ovulation time. Commonly used methods include: determination of basal body temperature curve, cervical mucus examination, determination of luteinizing hormone (LH) peak. Dynamic monitoring of follicular changes by B-ultrasound. If the patient has infection, fallopian tubes, uterine diseases or endometriosis in the medical history or physical examination, the doctor will choose hysterosalpingography, hysteroscopy or laparoscopy. In addition, endometrial biopsy will be used to determine whether the hormones produced by ovaries are appropriate.
U Q: Who is suitable for artificial insemination with husband's sperm?
Answer: It is suitable for artificial insemination of husband's sperm: (1) The man pours semen into the woman's vagina, such as impotence, paraplegia, hypospadias, retrograde ejaculation, etc. (2) The woman's cervix is abnormal, such as bad cervical mucus and serious cervical erosion; Or abnormal interaction between sperm and cervical mucus; (3) Men with abnormal sperm, such as high or low sperm count, low motility or abnormal sperm morphology; (4) If the woman ovulates irregularly or does not ovulate, the husband's sperm is artificially inseminated under supervision or after ovulation is promoted; (5) As a part of the "sperm bank", if the pre-stored sperm is artificially inseminated after vasectomy, testicular surgery or chemotherapy.
Q: What kinds of artificial insemination are there?
Answer: Artificial insemination is divided into husband artificial insemination, donor artificial insemination and mixed artificial insemination according to the semen used, that is, husband semen, donor semen and the first two semen are mixed together for artificial insemination. According to different methods, it can be divided into vaginal artificial insemination, cervical artificial insemination and intrauterine artificial insemination, and different methods are used for different patients.
What is artificial insemination?
A: Artificial insemination refers to injecting semen into female reproductive tract by artificial injection, so that infertile couples can have children. Human sperm bank, also known as human sperm bank, is the equipment and place for cryopreservation of human sperm, which generally refers to the medical or scientific research units that store, supply and use human sperm for artificial insemination to treat some male infertility. Artificial insemination and sperm bank are usually remedial measures to treat infertility.
U q: why do infertile couples have to have a comprehensive examination before medically assisted conception?
A: There are two purposes to conduct a comprehensive examination of infertile couples before medically assisted conception. The first is to determine whether it is necessary for medical assistance to conceive. Because medical assisted pregnancy is troublesome, the success rate is low and the cost is high, if it is not necessary, it can alleviate the unnecessary pain and economic burden of patients. The second is to find out the causes of infertility, so as to take corresponding medical assistance measures.
Q: Under what circumstances should medical assistance be considered for pregnancy?
A: Medical-assisted pregnancy is very troublesome to operate, with low success rate and high cost. Therefore, not all infertility is considered, but only after the failure of traditional treatment methods or when there is no other choice. For "unexplained" infertile couples, a comprehensive examination should be conducted before considering medical assistance for pregnancy. If there is no abnormality, the couple should be allowed to try pregnancy for at least two years. It is necessary to fully understand the situation of infertile couples after deciding to carry out medically assisted conception.
Q: What is medical assisted conception?
A: Medical assisted conception, also known as assisted reproduction, is a new concept with the rapid development of reproductive medicine in recent years. It refers to the conception of infertile patients through medical means, including previous artificial insemination, newly emerged tubal transplantation, fertilized egg tubal transplantation, gametophyte fertilization (IVF) intrauterine transplantation, sperm microinjection and other new technologies.
U Q: Will men really be laid off?
A: If there are more and more single women in the world one day, please don't be surprised, because men should also be laid off. Scientists believe that in the near future, with the development of high technology, those infertile women or men can also have a healthy baby and taste the feeling of being parents. So far, scientists have developed various methods to meet the needs of women who are infertile for different reasons.
1. Use adult cells
At the beginning of this year, two teams of scientists from the United States and Australia announced that they had carried out experiments on mice to make them pregnant without sperm, and the results were very successful. Eggs can be "fertilized" with an adult cell without sperm, and this method will be used for infertile men one day in the future.
2. Artificial insemination
Artificial insemination refers to the implantation of male sperm into female reproductive organs through test tubes. In the case of artificial fertilization, the effect is the same whether it is fresh sperm or frozen sperm. Of course, frozen sperm should be frozen first.
It will not be effective until it is thawed. After learning that they have cancer, some men will first store their sperm in the sperm bank and freeze them, and then take them out when they want to have children. This process must be carried out before the patient receives chemotherapy, because chemotherapy may affect the quality of sperm to some extent.
3. Use donated sperm to get pregnant
Using this method, the sperm used by women for artificial insemination comes from anonymous sperm donors instead of their sexual partners. This method is to put the sperm donated by the sperm donor into the sperm bank, freeze it in liquid nitrogen and take it out when necessary.
4. In vitro fertilization
From 65438 to 0978, after the birth of the first test-tube baby luis brown, artificial insemination has been the most basic method of unnatural pregnancy. Before in vitro fertilization, women usually inject or take some hormonal drugs. With the help of these drugs, women can excrete a large number of mature eggs. Doctors take these eggs out of women and take them to the laboratory for artificial insemination. Sperm usually belongs to her husband. After that, the doctor will implant multiple fertilized eggs into the woman's uterus at the same time.
5. In vitro fertilization before implantation
This method is suitable for the situation that one or both husband and wife suffer from hereditary diseases at the same time, and this hereditary disease will be transmitted to the baby through pregnancy.
6. Intracytoplasmic sperm injection
This method is different from artificial insemination. First of all, this method is suitable for men who cannot ejaculate normally. Therefore, doctors need to remove sperm from their testicles or epididymis by surgery, then implant a single sperm directly into the cytoplasm of an egg in the laboratory to fertilize it, and then implant the fertilized egg into a woman's uterus by normal methods.