Medicine was known in ancient India from a very early stage. A variety of medicines have also been found in the Harappan cultural sites, such as pentelin, a dark brown solution, for the treatment of indigestion, liver disease, rheumatism, etc.; bird quill bone, external application can be used to cure diseases of the ears, eyes, throat and skin, etc., and internal use of appetizing; antelope horns, antlers, coral, and nymphaea leaves, etc., which can also be used as medicines. At that time, people already knew that in the skull perforation, to treat headaches and other diseases, which is a difficult brain surgery, which shows that the medical technology and equipment has reached a fairly high level.