Tricalcium phosphate is a safe nutritional fortifier, mainly added to food to enhance calcium intake, and can also be used to prevent or treat symptoms of calcium deficiency. At the same time, tricalcium phosphate can also be used as an anti-caking agent, pH regulator, buffer, etc. in food. Such as flour anti-caking agent (dispersant), milk powder, candy, pudding, condiments, meat additives, animal oil refining aids, yeast food, etc.
Microencapsulated tricalcium phosphate, one of the best sources of calcium for the human body
Microencapsulated calcium (LIPOCAL) produced by the Spanish Lipofoods company is a calcium-based tricalcium phosphate. A calcium product that uses calcium as raw material, is ultrafinely crushed, and then wrapped with lecithin into microcapsules with a diameter of 3-5 microns.
LIPOCAL’s high absorbability is due to its use of lecithin for encapsulation. Since the molecular structure of lecithin is similar to that of phospholipids in the cell membrane of intestinal epithelial cells, when lecithin is exchanged with the cell membrane or directly embedded, it can increase the fluidity of the intestinal epithelial cell membrane, thus enhancing the absorption of nutrients. When calcium is released from the microcapsules, it can easily penetrate the intestinal mucosa or intercellular spaces and enter the blood circulation. An experiment by the University of Barcelona in Spain showed that the bioavailability of tricalcium phosphate can be increased by 41% after microencapsulation.
In addition, as one of the daily calcium sources, tricalcium phosphate has the advantage over other calcium supplement products that it can provide both calcium and phosphorus. It is very important to maintain a balance of calcium and phosphorus in the body, because these two minerals are essential substances for bone formation. Therefore, if the balance of the two substances cannot be achieved, and only calcium supplementation is performed, it is usually difficult to achieve the ideal calcium supplementation effect. Tricalcium phosphate has good biocompatibility, bioactivity and biodegradability. It is an ideal human hard tissue repair and replacement material and has been receiving close attention in the field of biomedical engineering. A special form of tricalcium phosphate—β-tricalcium phosphate—is commonly used in medicine.
Beta-tricalcium phosphate is mainly composed of calcium and phosphorus. Its composition is similar to the inorganic components of bone matrix and combines well with bone. Animal or human cells can grow, differentiate and reproduce normally on β-tricalcium phosphate materials. Through a large number of experimental studies, it has been proven that β-tricalcium phosphate has no adverse effects on bone marrow hematopoietic function, no rejection reaction, no acute toxic reaction, no carcinogenesis, and no allergic phenomenon. Therefore, β-tricalcium phosphate can be widely used in joint and spinal fusion, limb trauma, oral and maxillofacial surgery, cardiovascular surgery, and filling of periodontal cavities. As people's research on β-tricalcium phosphate continues to deepen, its application forms have also become diversified, and it has demonstrated better performance in clinical medicine.
Liang Ge and others found through experiments that the degree of hemolysis is <5%. When β-tricalcium phosphate is implanted into the human body, it can be degraded and absorbed in body fluids. After calcium and phosphorus are absorbed by body fluids, After entering the human circulation system, the β-tricalcium phosphate implanted into the human body gradually dissolves and disappears after a certain period of time, forming new bone.
Arai et al. used β-tricalcium phosphate porous ceramics to fill 8-15cm fibular segmental defects and achieved fibular regeneration. Reconstruction can be achieved on average 2 months after surgery. No displacement of the ankle joint or tibia will occur.
Zheng Chengze et al. used β-tricalcium phosphate combined with autologous bone marrow in clinical applications to repair tumor bone defects and old fracture bone defects. After postoperative investigation, the results showed the osteogenic effect of the implanted material. Obviously, the combination of β-tricalcium phosphate and autologous bone marrow is an ideal method for treating bone defects.
Zhang Handong and others used tricalcium phosphate ceramics to repair mandibular defects in rabbits. Studies have shown that there is no obvious inflammation or other reactions in local tissues after implantation.
Zhang Jianshe et al. implanted β-tricalcium phosphate ceramics with two different compositions into the mandibular artificial defect area. The doped tricalcium phosphate ceramics degraded slowly but had good biophase. Capacity.
Zhang Liang et al. used β-tricalcium phosphate/DL-PLA as a new material to treat bone defects. Studies have shown that its degradation characteristics are conducive to the ingrowth of bone tissue cells.
Mitenmuller et al. used ceramic particles with micropores as carriers of anti-tuberculosis drugs and antibiotics, and filled them into osteomyelitis-affected areas to basically repair the defective bone. S24/25Avoid contact with skin and eyes.
Avoid contact with skin and eyes.
R36/37/38Irritating to eyes, respiratory system and skin.
Irritating to eyes, respiratory system and skin. Health hazards: During production, processing and use, calcium phosphate powder can enter the respiratory tract, and its occupational hazards depend on the impurities silica and fluorine contained. According to relevant reports, phosphates may cause systemic toxic effects only when the dosage is very large, and there is no danger at dosages under normal production conditions.
Flame and explosion hazard: This product is non-flammable. Skin contact: Take off contaminated clothing and rinse with running water.
Eye contact: Lift eyelids and rinse with running water or saline. Seek medical attention.
Inhalation: Leave the scene to fresh air. If breathing is difficult, give oxygen. Seek medical attention.
Ingestion: Drink enough warm water to induce vomiting. Seek medical attention. Hazardous characteristics: No special combustion and explosion characteristics.
Hazardous Combustion Products: Natural decomposition products unknown.
Fire-fighting method: Move the container from the fire scene to an open area as much as possible. Operation precautions: Close operation and pay attention to ventilation. Operators must undergo special training and strictly abide by operating procedures. It is recommended that operators wear self-priming filter dust masks. Avoid dust generation. Avoid contact with acids. When transporting, load and unload gently to prevent damage to the packaging. Equipped with leakage emergency treatment equipment. Empty containers may contain harmful residues.
Storage precautions: Store in a cool, ventilated warehouse. Keep away from fire and heat sources. It should be stored separately from acids and avoid mixed storage. Suitable materials should be available in the storage area to contain spills.