When was Anacin banned
When was Anacin banned, from about the 1920s, Anacin was introduced and became a necessity in every household, whether it is a headache, or fever and joint pain, just need to take two tablets of Anacin can be relieved. When was Anacin banned.
When was Anacin banned1November 2, 2021.
A. What is Anacin
Anacin may be unfamiliar to the children of the 90's, but it is very familiar to those of the previous generation, and even to some of them, the mention of this "word", the mind will be infinite flashbacks of many childhood memories. The first time I saw it, it was a very good one, and I think it was a very good one.
When I was a kid, it seemed that when I had a fever, my parents would let us eat this, and the medicine was very effective in reducing the fever. However, as we grow older, we gradually found that this drug out of our vision, and even more drugstore inquiries, are no longer its figure.
So what exactly is anandamide and why was it suddenly banned?
Anacin began to be widely used in the 1920s of the last century, the main role of antipyretic and analgesic, has a very good fever, pain relief, all types of rheumatic pain, gout acute attack can be treated with anacin.
To put it bluntly, Anacin is a kind of non-steroidal anti-inflammatory drugs, and we live in the common ibuprofen and aspirin and other drugs belong to the same type.
During the time when Anacin was first introduced, it sold like hotcakes and was stocked in almost every household. However, it was banned in various countries soon after. The reason for this is mainly because of some side effects brought about by taking the drug.
Second, from ten thousand people sought after, to expressly prohibited
From about the 1920s, Anacin came out after the home of every family to become essential, whether it is a headache, or fever and joint pain, you only need to eat two tablets of Anacin can be relieved. At that time, Anacin could be called the "king of fever and pain", and no one knew about it.
But in the 1960s, the situation of Anacin took a turn for the worse.
In 1922-1934, there was a small outbreak of infection in the United States, a lot of people appeared in the end of the blood white blood cell reduction, immunity decline, and caused 1981 deaths, and then the relevant departments launched an investigation into this, and found that the source of this infection is a drug called aminopyralid, and the chemical composition of Anacin is mainly aminopyralid and sodium sulfite.
Then there was a lot of controversy in the medical community about anandamide, until there were deaths caused by anandamide in countries all over the world, and in 1965, the Australian Department of Health officially banned the prohibition of anandamide.
Subsequently, Norway, the United States, India, China and other countries also stopped importing or producing anandamide.
The "miracle drug" of the generation became a "prisoner", and was officially put into the cold palace by countries all over the world.
Three, "cheap is not good", Anacin "side effects" how big?
Auntie Liu's kidney failure ......
The discovery of kidney failure was an "accidental" opportunity, and Auntie Liu's routine checkups prior to surgery for uterine fibroids revealed high blood pressure, moderate anemia, and abnormally high creatinine levels. The company's website is a great source of information about the company's products and services, and the company's website is a great source of information about the company's products and services, and the company's products and services.
This makes Mrs. Liu very puzzled, how could she have kidney failure? The doctor asked about the recent past history of the mother in the follow-up, the heart probably have a number.
It turns out, Liu has been in the past few years the habit of taking Anacin, the beginning of the headache when the drug, the late development of the symptoms of discomfort to take Anacin, has not gone to the regular hospital, so Liu has been taking the drug for nearly 10 years.
The most common side effect of taking Anacin is kidney damage, in nephrotoxic drugs can be ranked among the top three, long-term high-dose use of Anacin, so that Liu's kidneys are overburdened, and gradually developed into kidney failure.
The side effects of anandamide are more than kidney failure
In fact, the side effects that anandamide can bring are far more than kidney failure, it can also cause these five side effects to appear.
1, skin
After taking anakinra, some people will appear skin damage, mostly manifested as a rash, including urticaria, erythema, itching, etc.; some serious patients will also appear polyphenoidal erythema, toxic epidermal necrolysis and so on.
2, gastrointestinal
Anakin common gastrointestinal side effects for nausea, vomiting, flatulence, and peptic gastric ulcer bleeding, serious patients will cause hemorrhagic necrotizing enteritis.
3, systemic
After taking the drug may appear dyspnea, palpitations, facial edema, chest tightness, and a drop in blood pressure and other symptoms, and severe even induce anaphylactic shock leading to death.
4, the blood system
Anacin can cause leukopenia, thrombocytopenia, aplastic anemia disorder, as well as allergic purpura, and so on, clinically there have been cases of death due to outbreak of purpura caused by the drug.
5, the urinary system
Anacin can cause hematuria, renal function abnormalities, and some patients may even have acute renal failure.
Four, fever without anakinra, how should I choose antipyretic drugs?
We all know that the human body temperature exceeds 38.5 ℃, it is recommended to medication to cool down, but for some of the patients with fever think that a fever to go to the hospital, some of the fuss, most of the choice to take medication at home to reduce fever, in the anandamide is banned, many people will feel that the fever is no medicine, in fact, in fact, not, and there are a variety of drugs can be treated for fever, the 4 kinds of very common. The first is the one that you have to take at home to get rid of your fever.
① Acetaminophen
Acetaminophen fever is very fast, is the most commonly used children's class of antipyretic medication in clinical practice, which is more gentle and has no side effects, and is generally suitable for use by children under the age of two. However, it has the disadvantage of controlling the body temperature for only about 2 hours, which is a shorter period of time than other medications.
② Ibuprofen
Ibuprofen is known to most women as the "savior" of menstrual cramps. But few people know that ibuprofen also has the role of fever, ibuprofen and acetaminophen, are relatively safe, and ibuprofen fever lasts longer, generally can continue for about 8 hours. It is very effective in reducing fever in patients with high fever, and is generally recommended clinically for children over 3 years of age with high fever.
③ Nimesulide
Nimesulide is more controversial in the international arena, Spain, Ireland and other countries have banned the drug, but in our country is still still in use, its advantage is that the digestive system has fewer adverse reactions, but may increase the burden on the liver, so this kind of antipyretic drug is recommended to be taken under the direction of a doctor's advice, and not recommended to be taken by the patient himself. It is recommended that patients take it by themselves.
In life, no matter what medication you take, you need to have the guidance of a professional doctor, like Liu's behavior of blindly taking medication for many years is very undesirable!
When was anandamide banned2
A. What is anandamide?
Anacin is a combination of aminopyralid and sodium sulfite compound, soluble in water, with antipyretic and analgesic pharmacological effects, faster than the use of aminopyralid alone, so many people like to use anacin to reduce fever.
In 1922, Anacin was marketed in Germany as a fever-reducing drug, but it was followed by a number of serious adverse events, and there were reports that Anacin could trigger fatal granulocytopenia.
By 1977, the FDA officially issued a ban on anandamide, withdrawing it from the U.S. market. Subsequently, anandamide was banned in several countries around the world, including Japan and Australia.
In China, Anacin was developed and successfully marketed by a Shanghai pharmaceutical company in 1952, and because of its effectiveness, Anacin was popular for a while, on a par with acetaminophen, aspirin, and other drugs, solidifying its position in the drug world.
But in 2020, the safety of Anacin caused concern, was sentenced to "death" by the State Drug Administration - a variety of preparations to stop the production of Anacin tablets are prohibited under the age of 18 years, pregnant women should be cautious or prohibited.
2. Why is it banned in many countries?
When Anacin was first introduced to the market, it had a great advantage over other drugs, one being that it was effective, and the other being that it was cheap. But widespread use also led to an increasing number of adverse events, and people began to look for alternatives to it.
At this time, more and more antipyretic and analgesic drugs on the market to meet the needs of different patients, Anacin is no longer the only choice, and gradually withdrawn from the stage of history.
In 2008, the National Center for Adverse Drug Reactions (NCADR) released the "Adverse Drug Reaction Monitoring Information Bulletin", which provides detailed statistics on the adverse reactions of anandamide, including 7 cases of anaphylactic shock death, 1 case of death from adverse reactions in the blood system, 4 cases of death from skin and its ancillary reactions, 5 cases of death from adverse reactions in the urinary system, and 4 cases of death from adverse reactions in the digestive system.
Then later, this once "miracle drug" let a lot of doctors and pharmacists, "smell of change", in addition to a small number of primary health care institutions will be applied, the city's health care institutions have basically abandoned the use.
In the revised manual, a detailed explanation of the serious adverse reactions of anakinra:
1, skin damage
Including urticaria, erythema, exudative erythema, skin ulcers and necrosis, herpes blisters, exfoliative dermatitis, acute generalized eruptive pustulosis, toxic necrolytic pustulosis, polyposis, severe polyposis, erythema, and other skin conditions. erythema multiforme, and erythema multiforme major.
2, gastrointestinal damage
Causes nausea and vomiting, stomach pain, gastric discomfort, account period, gastrointestinal bleeding, peptic ulcer bleeding.
3, systemic damage
can cause lips, face, eyes, periorbital and other parts of the edema, but also cause chest tightness palpitations, dyspnea, acute laryngeal edema, asthma, blood pressure drop problem, severe anaphylactic shock, there is a risk of death.
4, blood system damage
can lead to leukocytes, granulocytes, platelets, causing granulocyte deficiency; or induced by cataracts, thrombocytopenic purpura, anaphylactic purpura, as well as acute hemolytic anemia, autoimmune hemolytic anemia, and other blood diseases.
5, urological damage
Causes hematuria, renal function abnormalities.
6, other
There may be dizziness, headache, local numbness and other neurological adverse reactions, as well as liver cell damage.
3. Can Anacin still be used?
See this, many people will feel pity, is Anacin completely can not be used?
In fact, Anacin still has some clinical value, the instructions strictly limit the scope of the applicable population and indications, for patients who meet the requirements, can be used under the guidance of the doctor.
For the choice of antipyretic drugs for children, the World Health Organization and China's Fever Guidelines agree that there are only two currently recognized, safe and effective antipyretic drugs for children - ibuprofen and acetaminophen.
Both adults and children should pay attention to four points when using analgesics and antipyretics:
1. Don't overdose
Overdose is prone to dependence, which also elevates the risk of liver and kidney failure and induces other diseases.
2, do not take long-term
Long-term use of easy to damage the digestive tract and liver and kidney function. In general, take antipyretic drugs no more than 3 days, analgesics no more than 5 days.
3, do not combine drugs
Combined use of drugs may increase adverse reactions, reduce the efficacy of the treatment, especially for patients with chronic illnesses, it is best to consult a doctor or pharmacist first, to avoid the wrong medication.
4, contraindications do not use
Peptic ulcer patients, liver and kidney insufficiency is prohibited, pregnant women should be cautious.
Once the "miracle drug" Anacin, no longer frequent, many people thought it was too cheap and was discontinued, in fact, it is not. Anacin out of the stage of history, mainly because of its serious adverse reactions, and there are constantly new alternatives, discontinued just follow the trend of history.
When was Anacin banned3
Recently, the State Drug Administration issued a "notice on the cancellation of the certificate of registration of mercury bromide solution and other 34 drugs (No. 132 of 2021)" notice.
The Announcement canceled the registration certificates of 34 medicines such as mercury bromide solution, among which "Anacin tablets" is in the cancellation list.
Anacin tablets in the impression of several generations can be said to be the "miracle cure". Anacin has been banned in many countries because of its serious adverse effects. Anacin is a pyrazolone antipyretic and analgesic, and its main components are "aminopyralid and sodium sulfite."
Studies have shown that the clinical application of anacin has led to side effects that are mainly manifested in a number of ways:
1. Hematological: it can cause agranulocyte deficiencies, with a prevalence rate of about 1.1 percent, with an acute onset of symptoms, and in severe cases, with fatal consequences. In severe cases, it is fatal, and can also cause autoimmune hemolytic anemia, thrombocytopenic purpura, aplastic anemia, etc.
2. Skin: it can cause urticaria, oozing erythema and other allergic manifestations, and in severe cases, it can cause exfoliative dermatitis, epidermolysis bullosa, etc.
3. Local reactions: redness, swelling, and pain at the site of injection, which will only subside in a few days; some patients have symptoms of toxaemia, and the skin is bleeding, and the blood is not clear. Toxemia symptoms, subcutaneous hemorrhagic spots, or purple-black pus, often take months to heal.
4. Allergic shock: allergic rash or drug fever, urticaria, severe cases may have exfoliative dermatitis, herpetic epidermolysis bullosa leading to death. Individual cases can occur anaphylactic shock, and even lead to death.