Writing Ideas: to achieve a clear, natural, understandable, not cluttered, to pour their thoughts and feelings, or explore the true meaning of life, or talk about ideological issues, the spirit of governance, so that the reader is enlightened and educated. Such an article has a philosophy, giving the reader's feelings are also richer.
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Project introduction:
This project focuses on engineering technology research around the key technical problems of bioreactors, and adopts plant oleosome system to realize the high efficiency expression of exogenous proteins, and solves the protein separation and purification, problems; based on molecular chaperones and recombinant proteins*** expression of the theory of the exogenous proteins soluble expression system, and the soluble expression system of exogenous proteins. The soluble and efficient expression of exogenous proteins has been realized; the problems of easy degradation, instability and short half-life of exogenous drug proteins have been solved by adopting the fixed-point chemical modification technology;
The advantages of using the edible fungus mycelium, which has the ability to express exogenous proteins, and has a short growth cycle and is easy to be produced on a large scale, have been used to set up a technical platform for the expression of exogenous proteins in edible fungus; and the secretion-type expression system in Escherichia coli has been used to secret the target Using E. coli secretion-type expression system, the target protein is secreted into the periplasm of the cell, which reduces the purification step and lowers the production cost, and makes the quality of the product more controllable.
Using the fibroblast growth factors (FGFs) and growth hormones expressed by the above key bioreactor technologies, we have successively developed lyophilized powder reagents, eye drops, injections, gels, and interventional national Class II medical devices. At present, the above drugs and machines have entered into clinical trials, designed for large-area burns, chronic hard-to-heal wounds, chronic granulation wounds, wound healing after plastic surgery and growth hormone deficiency.
The project applied for 11 national invention patents, was authorized 8, patented technology products in the past three years the cumulative output value of 1. 158 billion yuan, resulting in significant economic and social benefits.