INR: It stands for International Normalized Ratio. The INR is calculated using the PT ratio of reference plasma to normal plasma measured by thrombin and the ISI value labeled by the reagent used, making the results measured by different thrombin reagents comparable. High coagulation activity.
Histopathologic changes The epidermis showed papillomatous hyperplasia with hypertrophy of the stratum spinosum. There is mild hyperkeratosis and hyperkeratosis on the surface. Vacuolated cells can be seen in the spinous cells and granular layer, the cell cytosol is large, with a round, y stained nucleus, perinuclear vacuolization, light staining, in the nuclear membrane and plasma membrane between the filaments connected to make the cell catamenial shape. Vacuolated cells are characteristic of acanthosis, and are more pronounced in the middle and upper layers of the acanthocytes. The superficial dermis has a moderately dense perivascular infiltrate, dominated by lymphocytes, and a plasma cell infiltrate is also seen. Dilatation of blood vessels in the papillary part of the dermis, widening of the papillae and upward extension.