1. siRNA gene silencing technology:
In 1998, the discovery of RNA (ribonucleic acid) interfering mechanism by American scientists Andrew Farr and Craig Mello caused a worldwide sensation. In recent years, the siRNA (small interfering RNA) gene silencing technology formed by the discovery has become a hotspot for biological research and future drug development due to its important role in the prevention and treatment of important diseases such as cancer, AIDS, hepatitis, SARS, etc. Farr and Mello were also awarded the 2006 Nobel Prize in Physiology and Medicine.
Pigmentation is called the cancer of the beauty world, and its pathogenesis, like cancer, is the abnormal expression of normal genes in the skin. The scientists of the Charm of the Dumping City, the use of siRNA technology to make the formation of pigmentation of the relevant genes silenced (loss of action), is a fundamental method of treating and preventing facial pigmentation, and the traditional inhibition of tyrosinase activity (e.g., arbutin, etc.), melanin cytotoxicity (e.g., hydroquinone, heavy metal, etc.), keratin layer (including epidermal layer) peeling method (such as retinoic acid, fruit acid, laser, photorejuvenation, etc.), pigment reduction method (Vc, Ve, coenzyme Q, GSH, etc.) compared with the more accurate target point, better results, minimal side effects, is a revolutionary breakthrough in skin whitening and spot removal!
2, cell growth factor repair and metabolism promotion technology:
Skin consists of epidermis, dermis and subcutaneous tissues of the cell composition, is the body's important barrier protection organ, toxin excretory organs, information exchange organs, beautiful show organs, cell growth factor is the skin normal metabolism, damaged repair of the important promotion of substances. Skin exposure, so that it is subject to the influence of various environmental factors, will be damaged, aging, resulting in dehydration, dryness, roughness, dullness, flaccidity, wrinkles, acne, eczema, allergies and other symptoms. Various cell growth factors for their respective target cells for maintenance, repair role, to maintain normal cells, so that the skin healthy, beautiful muscle!
The scientists of Charm of the City, before producing the brand of Charm of the City, have been known worldwide as the producer of many cell growth factor raw materials, providing raw materials to many famous pharmaceutical companies and cosmetic manufacturers in the United States, Japan, France, China, etc., including aFGF, bFGF, EGF, KGF, NGF, TGF, PDGF, etc. The products of Charm of the City have been used in many different ways, including the use of aFGF, bFGF, EGF, NGF, TGF, PDGF and so on. The Charm of the City products make full use of this scientific and technological advantage, sub-systems, into a system to provide a variety of skin, all kinds of people to use the product mix, a step ahead of the first time out of the world, a superior!
3, intercellular information transfer and effect control technology:
The human body is composed of a variety of highly differentiated specific cells, cell generation, development, metabolism, efficacy, death and other physiological phenomena, the completion of the need for three types of substances, namely, genes, nutrients, regulatory substances, genes from parents, nutrients from the environment, regulatory substances from the specific differentiation of glandular cells or neighboring cells. The genetic material comes from the parents, the nutrient element comes from the environment, and the regulatory material comes from the specialized differentiation of glandular cells or neighboring cells. Cellular regulatory substances, also known as information substances, include neurotransmitters, hormones, cytokines, and so on. The way of intercellular information transfer and effect control is:
Specific cell secretion and release of information substances (or man-made in vitro) - information substances through diffusion or blood circulation to the target cell - and the target cell receptor (transmembrane or intracellular receptor) specific binding - and the target cell receptor (transmembrane or intracellular receptor) specific binding - and the target cell receptor. specific binding to a receptor (transmembrane receptor or intracellular receptor) in the target cell - conversion of the signal by the receptor and activation of the messenger system in the target cell - biological function of the target cell.
A problem in each of the above control processes can produce disease, and many of the problems of human skin are also related to abnormalities in the transmission and control of this information between skin cells, such as allergies, redness, acne and so on. The first "interleukin (one of the important cytokines that mediate tissue inflammation and immune response) receptor blocker" created by the scientists of the Charm of the City, has a direct intervention treatment and preventive health care effect on the allergies caused by various factors of the skin, and the after-effects of the allergies (e.g., acne, redness, corneal macules, etc.).
4, free radical annihilation and cellular preservation, anti-aging technology:
Free radicals, also known as free radicals, is a class of atoms or groups with unpaired electrons, its single electron has a strong tendency to pair, thus triggering the chemical chain reaction such as an atomic bomb explosion to grab the electrons, the surrounding material causing enormous damage!
Free radical damage to cells and tissues is the basis of its pathogenicity. Free radicals destroy cell membranes, resulting in cell membrane degeneration, so that the cells can not absorb nutrients from the outside, but also the excretion of metabolic wastes within the cell, and lost the ability to resist bacteria and viruses; free radicals attack the genes that are being replicated, resulting in gene mutation induced cancer; free radicals activate the body's immune system, the release of a variety of inflammatory factors, so that the skin appears to be red, swollen, itchy, ulceration, increasing the extent of skin damage to the skin, such as pimples. Skin disease on the skin damage; free radicals can destroy collagen and other connective tissue, so that the skin loses elasticity, roughness, wrinkles, etc.; free radicals erode the eye lens tissue, causing cataracts and so on. In short, free radicals interfere with important physiological processes, and the formation of more than 100 kinds of diseases, including heart disease, atherosclerosis, phlebitis, arthritis, allergies, senile dementia, coronary heart disease and cancer. Medical research has shown that free radicals are produced when humans are in extreme bad moods, such as anger, tension and fear. Pollutants such as ultraviolet rays, X-rays, electromagnetic waves, carcinogens, alcohol, smoking, automobile exhaust, and pesticides in modern society also lead to the production of free radicals.
The "metal sulfur protein, glutathione combination" free radical annihilation system developed by the scientists of the Charm of the City, can effectively control the skin's free radical outbreaks, is the prevention of skin diseases, beauty and health care of the root cause of the problem!
5, biological antimicrobial peptide environmental shielding and protection technology:
Biological antimicrobial peptide is a general term for antimicrobial peptides with antibacterial activity, which are widely present in insects, plants, animals and humans, with non-specific anti-bacterial, fungal, viral, and tumor cell effects, also known as peptide antibiotics, in the body to resist the invasion of pathogens play an important role.
As a result of the abuse of antibiotics and pesticides over the last hundred years, many human pathogenic microorganisms have become resistant to drugs, and the treatment of human skin infections such as acne, psoriasis, sweat duct warts, eyelid warts, and other common pathogenic microorganisms is becoming more and more difficult! The Charm of the City scientists use genetic engineering technology, the development of antimicrobial peptide, with broad-spectrum bactericidal effect, with a small relative molecular weight, heat stability, water solubility, etc., more importantly, this antimicrobial peptide on the eukaryotic cells (eg, human cells) have no effect, only on the role of the prokaryotic cells and the occurrence of lesions of eukaryotic cells, and at the same time can improve the skin's immune system in the skin in terms of the maintenance of the environmental barriers and protective effect, has great significance and prospects for application. has great significance and application prospects.
6, biological microencapsulation of natural products and rapid penetration technology:
Natural products are the material basis for human generation, evolution and development, and also the source of drugs for the pursuit of beauty and victory over various diseases. For the treatment of various problematic skin and the need to maintain youth and beauty, the natural product bio-micro-encapsulation and promotion of penetration and absorption technology pioneered by the scientists of the Charm of the City, has the following advantages:
a, the use of CO2 low-temperature supercritical extraction and purification and other advanced bio-manufacturing technology, to ensure that the unity of the natural products of the unity of the activity and purity.
b, the use of unique in vitro cell engineering model, targeted screening of small molecular weight active ingredients needed by the skin, to facilitate rapid skin absorption.
c, the active ingredients will be vacuum frozen, bisexual microencapsulation and aseptic modular packaging processing, so that the product can be preserved at room temperature for more than 24 months.
d, the active microcapsules before use and then with a special serum for the second conformation processing, so that the active ingredients can quickly ultra-micro-permeable to the target cells on the specificity of the receptor, the start of the cellular response, the efficacy of the increase of more than 5000 times.