It is necessary to know each other first, and then understand each other. Everything is the same, and growth hormone is no exception. So let's take a look at the main brands of growth hormone listed in China at present, so as to know fairly well.
Comprehensive information list of main growth hormone products in China
The above picture only shows the general situation of the main growth hormone products in China, but how to choose a growth hormone suitable for children? Don't worry, let's look down step by step.
Evaluation item 1: growth hormone dosage form and brand.
In the face of many growth hormone brands and products, many parents and friends who come into contact for the first time are ignorant. How to learn to simplify the complex and clearly understand the differences between many information? Listen to the opinions of experts.
Doctor of Medicine, Professor of Peking Union Medical College/Dr. Wu Xueyan, Chief Physician of Endocrinology Department of Peking Union Medical College Hospital.
Q: What kinds of growth hormones are there? What is the difference?
Answer: According to the form of growth hormone preparation, it can be divided into freeze-dried powder injection and liquid water injection. Natural growth hormone originally exists in liquid form in body fluids. At first, in order to solve the problem of long-term preservation of growth hormone, and at the same time, due to the limitation of early preparation technology, it can only be dehydrated at low temperature to make freeze-dried powder injection. Just like before the invention of refrigerator, people usually only salted fresh meat and dried it to make preserved meat, so as to achieve the purpose of long-term preservation without deterioration; The other preparation is injectable and exists in a more physiological and natural liquid form. Compared with freeze-dried powder injection, the molecular structure of water injection is closer to nature, with higher purity and activity, fewer antibodies and more convenient use. Obviously, the latter is the result and product of the progress of preparation technology.
In addition, growth hormone can be divided into short-acting and long-acting preparations according to the duration of action. Short-acting drugs include freeze-dried powder injection and short-acting water injection; Long-acting preparation is long-acting growth hormone water injection, which is a revolutionary progress of biological preparation technology in protein in the history of human pharmacy! At present, a lot of clinical experience has proved that long-acting growth hormone water injection is as safe and effective as short-acting water injection. Apart from the difference in molecular structure and combination, the biggest difference between short-acting and long-acting preparations in clinic is whether it is necessary to inject every day. Short-acting preparations should be injected every day, 365 needles a year. The long-term effect can be extended to once a week, with only 52 stitches a year. Therefore, patients who use long-acting preparations, especially those who are afraid of frequent injections, students who live in school and have the opportunity to go home on weekends, and adults who travel frequently, have greatly improved their treatment compliance and convenience, and at the same time greatly protected their personal privacy.
In order to let parents and friends know more clearly and intuitively, we summarize the growth hormone brands on the market into the following chart according to their dosage forms.
Comparison chart of relevant data of growth hormone product dosage form brand
Knocking on the blackboard: growth hormone can be divided into powder, short-acting water agent and long-acting water agent; Compared with powder, aqueous solution is closer to natural growth hormone, with higher purity and activity, fewer antibodies and more convenient use. The frequency of injection of long-acting growth hormone is lower than that of short-acting injection, and weekly injection replaces daily injection, which is more acceptable to children by reducing 3 13 injections per year. The listing of long-acting growth hormone represents the revolutionary progress of biological preparation technology in protein.
Evaluation Item 2: Safety of Growth Hormone
It is no small matter for children to take drugs. Whether the drug is safe or not and whether there are any side effects is the most concerned thing for every parent. Is growth hormone safe? What precautions should parents pay special attention to? Clinical experts have something to say.
Wu Kangmin, professor and tutor of master students, director of short-term physical research center of West China Second Hospital of Sichuan University.
Q: According to your clinical experience, is it safe to use growth hormone? Which is more reassuring?
A: The clinical application of growth hormone has been more than 30 years. As the national regulatory agencies of drugs, the US Food and Drug Administration (FDA) and the US Food and Drug Administration (CFDA) in China have both approved the use of growth hormone to treat short stature in children, so it is very safe to use it under the guidance of professional doctors. It can be said that the growth hormone products that have been listed are trustworthy. If there are potential safety hazards, the relevant departments will never approve their listing. But at the same time, parents should also know that growth hormone is a prescription drug and can only be used after being diagnosed by a clinician.
Although the drug is safe, there are many safety risks in the operation because growth hormone needs long-term injection and many parents have no medical experience. First of all, parents must listen to the guidance of medical staff in their daily injection operations and choose syringes suitable for their children. In addition, because children's height and weight change rapidly, it is necessary to adjust the dosage frequently, and a drug often needs to be used many times. In order to reduce the risk of infection, it is recommended to choose growth hormone containing antibacterial ingredients. Secondly, growth hormone, as a protein drug, needs high temperature. High temperature will not only affect the quality of drugs, but also affect the efficacy and safety. At present, most of the growth hormone drugs used in clinic need to be stored at 2-8℃, and some manufacturers have even realized full program-controlled cold chain transportation. Of course, some manufacturers have introduced the concept of normal temperature storage. But I want to remind parents here, because many people may not know the definition of normal body temperature at all. Normal body temperature is 20 ~ 25℃. For example, in some areas of southern China, the temperature exceeds the normal temperature for more than 200 days in a year, so we must not ignore the temperature control, so as not to affect the quality of drugs and delay the treatment of children.
From this point of view, it is safe to treat short children with growth hormone drugs, but parents should pay attention to the following aspects in their daily operation.
Comparison chart of related factors affecting the safety of growth hormone
Knocking on the blackboard: growth hormone has been used clinically for many years, and parents can safely give it to their children; As a prescription drug, the use of growth hormone should follow the doctor's advice; The daily storage temperature of growth hormone is strict, and the temperature is related to the safety and efficacy of drugs. At present, most drugs on the market are stored in cold storage at 2-8℃, and the whole cold chain is recommended. The injection process should be standardized, and an injection device suitable for children can be selected for easy operation; The dosage of growth hormone needs to be adjusted frequently, and a single drug often needs to be used many times. In order to reduce the risk of infection, it is recommended to choose drugs containing antibacterial ingredients.
Evaluation Item 3: Therapeutic Effect of Growth Hormone
In addition to safety, curative effect is also the most concerned issue for parents. Now that you have decided to give your child growth hormone, you naturally expect satisfactory results. Whether the curative effect is good or not, doctors often get feedback from patients at the first time, so clinical experts are still authoritative people with the right to speak.
Wang Chunlin, MD, tutor of master students, deputy director of pediatrics and director of neonatology department of Children's Hospital affiliated to Zhejiang University School of Medicine.
Q: Which growth hormone brand will be more effective? Is imported better than domestic ones?
A: The curative effect of growth hormone depends mainly on the time when children start treatment and whether they can insist on injecting drugs. There is a significant difference in the influence of children's final height between starting treatment at the age of 5 and returning treatment at the age of 10; Children insist on injecting every day, holding the mentality of fishing for three days and drying the net for two days, and the results must be different.
For the choice of growth hormone, I suggest that we should try our best to choose drugs suitable for children and make them more willing to cooperate with the treatment. Children's attention is often different from that of adults. Parents are concerned about the safety and efficacy of drugs, and children are thinking about why they need injections. Does the injection hurt? Can you call less often? If the child is unwilling to cooperate, even the best medicine is in vain. Compared with powder, the injection operation of aqueous solution is simpler and takes effect faster, which can help children build up confidence and cooperate more in the early stage of medication. Compared with the short-term effect, the long-term effect does not need to be injected every day, and children with little pain are naturally willing to treat it. Furthermore, the growth hormone secreted by the human body has its natural and unique molecular space structure, just as people all know that eating seafood should go to the seaside because they can taste the original delicious food. If you take seafood back in cold storage, the taste will be greatly reduced, so the closer it is to natural growth hormone, the more assured the curative effect will be. Finally, parents' daily storage of growth hormone will also interfere with the curative effect. It is recommended to store and use in strict accordance with the instruction temperature to maximize the effect.
As to whether imported products are better or domestic products are stronger, we should also treat this problem rationally and dialectically. With the development of the times and the progress of society, there is no need to blindly follow the old ideas about the quality of growth hormone products. The advantage of imported products in the past was due to the limitation of technical means. Domestic growth hormone field has long been monopolized by imported products, and the price is too high for most patients. We doctors can only "hope for medicine and sigh". However, in the past two decades, the technical level of growth hormone in China has developed rapidly. China has developed the world's first long-acting pegylated growth hormone, and its research and development strength has surpassed that of the international community. In addition, it is worth noting that countries have different requirements for drug listing, and China's standards are generally higher than those in Europe and America, so we have reason to believe that the starting point of domestic growth hormone is higher than that of imported products. Moreover, compared with the imported growth hormone, domestic products will accumulate more experience in using drugs for children in China, and they will be more targeted by China people in terms of the effectiveness and safety of long-term use.
Indeed, when choosing drugs for children, remember not to follow blindly. Only by fully understanding and rational judgment can we choose growth hormone suitable for children and achieve satisfactory curative effect.
Comparison chart of related factors affecting the curative effect of growth hormone
Knocking on the blackboard: judging the curative effect of growth hormone depends more on the time when the child starts treatment and the compliance with the product; It is suggested to choose drugs suitable for children as much as possible, so that children are more willing to cooperate with the treatment, such as simplifying the number of injections and matching exclusive injection devices; The medicine is close to nature, and the curative effect will be more guaranteed; The control of temperature is conducive to the maximum effect of growth hormone; Don't choose imported products blindly.
Evaluation Item 4: Growth Hormone Injection Device
Pediatricians generally recommend drugs that children can easily accept and parents can easily operate. If you eat once a day, you won't consider eating three times a day. If you can choose the taste of fruit, you will try to avoid the bitter taste of traditional medicine. Back to the products that need daily injection therapy, such as growth hormone, we think the choice of injection devices should also be evaluated.
Master student, member of Pediatric Branch of Chinese Medical Association, Chen Yongxing, deputy director of Endocrinology, Genetics and Metabolism Department of Henan Children's Hospital.
Q: What are the main injection devices for growth hormone? What kind of injection device is more suitable for children?
A: Although we and patients are looking forward to the market of oral products, at this stage growth hormone therapy still needs subcutaneous injection to take effect, so it is particularly important to choose an injection device suitable for children.
The injection devices on the market mainly include disposable syringes, disposable prefilled syringes, mechanical injection pens and hidden needle electronic injection pens. Children are relatively young, have weak endurance and have a strong fear of needles. The challenge of hitting children and parents every day is undoubtedly enormous. For growth hormone therapy, we have always emphasized compliance, that is, continuous medication without interruption, so it is a key issue to make children willing to accept daily injections. Parents are advised to carefully choose injection devices suitable for their children when choosing growth hormone products. For example, it is a crucial step for children to receive injections smoothly; For another example, if the needle is shorter and thinner, the pain of injection will be weakened; Also, if the number of injections is reduced, the child's cooperation will naturally be higher; In addition, growth hormone is operated by parents or children at home most of the time, so the convenience and safety of the operation process are also issues that parents need to consider, such as whether electronic operation can effectively avoid human errors and so on. In a word, we hope to see the research and innovation of injection device specially designed for children, so as to effectively eliminate the fear caused by injection, keep children away from pain, facilitate long-term treatment and obtain satisfactory height.
Indeed, since the development of growth hormone, the injection device has been continuously improved, and now it has been gradually upgraded to electronic products. After searching the data, we found the parameters of several commonly used injection devices with growth hormone drugs in the market and made a simple comparison for parents to choose by themselves.
Comparison diagram of growth hormone injection device
Knocking on the blackboard: at present, the clinical application of growth hormone can only be administered by subcutaneous injection; Judging from the injection devices on the market, the hidden needle electronic injection pen is more suitable for children to use, the hidden needle is shorter, thinner and safer, the electronic operation is more convenient, and children can also inject themselves.
Evaluation Item 5: Patient Use Ratio
At one time, we were "sighing at the ocean" about growth hormone drugs. Now, more and more children in China are receiving growth hormone therapy. According to the latest data survey, let's find out the proportion of patients who use growth hormone in major brands at present.
Proportion chart of growth hormone actually selected by patients
Knocking on the blackboard: It can be seen from the proportion of patients' medication in recent years that more parents are willing to choose domestic growth hormone; As Jinsai Pharmaceutical Co., Ltd. is the earliest and most complete domestic growth hormone producer in China, its related products have obvious advantages at present.
In view of the comparison of the above evaluation items, it is not difficult to extract the following important information about the selection of growth hormone:
1, the upgrade of growth hormone dosage forms has brought better drug sensitivity and clinical efficacy to users. Generally speaking, water is better than powder, and the long-term effect is better than the short-term effect. At present, the long-term effect is cost-effective.
2. As a long-term medication, compliance is a crucial link to test the efficacy of growth hormone. It is recommended to choose drugs and injection devices suitable for children, so that children are more willing to cooperate with treatment;
3. Home injection environment is complicated. For safety reasons, if a single growth hormone needs to be used many times, it is recommended to choose growth hormone drugs containing antibacterial components;
4. Temperature affects the safety and effectiveness of growth hormone. It is recommended to choose drugs stored at 2-8℃ and put them in the refrigerator, which makes it easier to control the temperature.
5. The domestically produced hormones have already represented the highest quality in the world, so the selection of imported products should be rationally analyzed;
6. Domestic growth hormone has become the choice of most families in China. As the earliest enterprise that listed growth hormone drugs in China, Jinsai Pharmaceutical currently uses the most patients.
How to choose the growth hormone suitable for children, do you have it? If you are also worried about your child's height, please ask your parents and friends to take your child to a professional medical institution for consultation and consultation.
May the children live up to expectations and thrive.