How to correctly select medical images of experimental animals

The choice of experimental animals is the first problem to be considered in medical scientific research. Because the choice of experimental animals is related to the quality of the subject, the amount of funds, the correctness of the research methods and the simplicity and complexity of the experimental methods, and even affects the success or failure of the subject and the correctness of the research results. Therefore, the selection of experimental animals must be an integral part of medical research, just like the literature retrieval of scientific and technological projects. At the same time, we must pay enough attention to the subject of experimental animal science. Secondly, we should know the basic knowledge of laboratory animal science, which is the basic condition for the correct selection of experimental animals.

First, commonly used experimental animals

Kangaroos (marsupials), armadillos (Ardentata), hedgehogs (insectivores), bats (Chiroptera), rabbits, pikas (rabbits), rats, mice, gophers, guinea pigs (rodents), finless porpoises (cetaceans), fur seals (Pinpoda) and so on.

Second, the basic principles of selecting experimental animals in biomedical experiments

1. Select animals with similar functions, metabolism, institutions and disease characteristics.

Non-human primates-the most evolved animals are the ideal animals closest to humans, such as macaques.

Other animals-although less evolved, can achieve experimental purposes, such as dogs, cats, pigs and so on.

2. Select experimental animals whose anatomical and physiological characteristics meet the requirements of the experimental purpose, and make full use of some special reactions of different varieties and strains of experimental animals. For example:

Thoracotomy and heart experiment-rabbits are suitable for experiments;

Experiments of fever, fever reduction and pyrogen examination-rabbits are suitable for experiments;

Observe the ovulation induction effect of drugs and take birth control pills.

Selection of rabbits and cats suitable for research;

Atherosclerosis experiment-suitable for rabbits, pigs and monkeys;

Experimental study on liver surgery-rats are suitable for selection;

Study on gallbladder function-rats can not be selected;

Vomiting experiment-both monkeys and cats are suitable;

Study on allergic reaction and Vc deficiency-for guinea pigs;

To study the contraceptive effect of drugs with estrogen activity-mice and rats should not be selected;

Animals of the same species and different strains have many special reactions, so attention should be paid to their selection and application.

3. Choose according to the purpose and content of the study.

Matching standardized animals

Standardized animals refer to animals raised through genetics, microbiology, environment and nutrition control.

Only by controlling microorganisms, environment and nutrition can animals be excluded from carrying microorganisms and parasites that affect the experimental results.

The influence of insects and potential diseases on the accuracy of results.

Genetic control can eliminate the individual differences caused by hybridization and genetic pollution in experimental animals, which will affect the repeatability of the results.