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The patient's symptoms are repeated blinking and dry eye, which is easily misdiagnosed as "dry eye", but it may actually be the early manifestation of Major syndrome. As one of the "incurable diseases", what is a major syndrome? What is the cause of this disease? How to deal with it? Director Liu, an old ophthalmologist in the Third People's Hospital of Henan Province (hereinafter referred to as the Third Hospital of Henan Province), combined with more than 40 years of medical experience, gave us a detailed introduction to major syndrome. Approaching severe syndrome, Liu Lao introduced that severe syndrome is a disabling and interdisciplinary disease, and its main manifestations are divided into two aspects: abnormal movement and abnormal non-movement. Kinematic abnormalities mainly include blepharospasm, dystonia of mouth, tongue, jaw, vocal cords and neck. Non-sports aspects can be manifested as mental disorder, sleep disorder, cognitive disorder and sensory abnormality. Mr. Liu said, don't underestimate this disease. From the point of view of ophthalmology, persistent eye muscle spasm will lead to functional blindness and inability to carry out normal work and life; Non-exercise, illness leads to serious mental disorders, and depression or anxiety makes patients suffer. In order to get rid of this disease, some patients go to great lengths to raise money for brain surgery at a cost of 300,000 yuan. Image source: Zhan Kuhailuo At present, the exact cause and pathogenesis of severe illness are still unclear. At present, it is believed that the imbalance of nerve media in the brain, especially acetylcholine and dopamine, is caused by psychological factors and drugs (antipsychotics, antipsychotics, antihistamines, etc.). ), trauma, oral surgery and maxillofacial surgery may be related to the occurrence of this disease. Based on his long-term clinical observation, Director Liu proposed that the main symptom should be psychosomatic disease, and spirit is an important inducing factor. In addition, the disease can also be induced by bad facial feelings, such as suspicion and panic caused by abnormal feelings after eye, oral and dental operations. The manifestations of major syndrome are very complicated. Many patients, especially in the early stage, will have repeated blinks and dry eyes, which are easily misdiagnosed as "dry eyes". According to statistics, it usually takes 4-6 years for patients with major syndrome to be diagnosed. Liu Lao introduced that the diagnosis of major syndrome abroad is "based on the stiff, bilateral and synchronous movements of orbicularis oculi muscle spasm, the recognition of sensory tricks and the increase of spontaneous blink rate". The "Expert's Clinical Diagnosis and Treatment Knowledge of Major Syndrome" published by Neuro-Ophthalmology Group of Ophthalmology Branch of Chinese Medical Association on 20 18 also mainly relies on eyelid spasm and/or facial muscle symmetry, irregular contraction, twitching phenomenon and disappearance during sleep. However, these diagnostic criteria do not take into account the problem of early diagnosis. Liu Lao said that according to his experience, in the early stage of Major's syndrome, except for dry eye symptoms, there is usually a dull pain between the eyebrows due to spasmodic contraction of the frown muscle, and eyebrow lines can be seen at the contraction of the frown muscle, and no matter the severity of the disease, it is "normal" for a period of time from morning. Such subtle discrimination is difficult to find if it is not based on careful observation of the clinical front line all the year round. In addition, the eyelid spasm of Major's syndrome is mostly bilateral, although the severity of both sides may be different. Hemifacial spasm, blepharospasm and spasm of corners of the mouth occur simultaneously, mostly unilaterally. Because the causes and symptoms of these two diseases are different, it is easier to distinguish them. At present, there is no radical cure for major syndrome, which is called "immortal cancer" because of its great harm and difficult to cure. Image source: Zhan Kuhailuo's current treatment is mainly symptomatic treatment to improve the quality of life of patients. Commonly used treatment methods include drug therapy, local injection of botulinum toxin and deep brain resection. Like other focal dystonia, Major's syndrome is thought to originate from basal ganglia circuit dysfunction. Therefore, drug therapy is also designed according to the neural media in the basal ganglia loop, such as anticholinergic drugs, dopamine inhibitors, aminobutyric acid and GABA receptor agonists. These drugs can relieve symptoms, but serious adverse reactions hinder their clinical application. Botulinum toxin injection has a certain effect, but it needs repeated injection, and with the increase of injection times, the effect will gradually weaken to be completely ineffective, and may cause neuromuscular atrophy at the injection site. In terms of surgery, it has been reported at home and abroad that deep brain electrical stimulation recommended by * * * can improve muscle tone to some extent, but it is not suitable for China's national conditions because of its nonspecific, systemic side effects, high technical requirements for equipment and high price. Exploring the mystery behind successful Major syndrome is considered to be a worldwide problem that has not been solved for a hundred years. Can the hospital in Zhengzhou really solve it? In the face of doubt, Liu Lao did not defend. In the past two years, Liu Lao's team has treated 2 13 critically ill patients from 25 provinces and cities across the country, ranging in age from 20 to 70, with a course of 6 months to 30 years. Banners and thank-you letters from all directions all reveal the gratitude of patients to Mr. Liu and his team. This banner hangs all over the hospital corridor. Image source: Director Liu of the Third People's Hospital of Henan Province achieved success through years of hard work. According to reports, Liu Lao still has to operate on critically ill patients every day, and an operation lasts for 4 or 5 hours. Time waits for no one. Even so, patients should be treated remotely after work during the day. Faced with consulting patients from all over the country, they are often busy until late at night. Liu Lao operated on the patient. Image source: After the operation in the Third People's Hospital of Henan Province, Liu Lao dozed off in the corner of the operating room, waiting for the next operation. Image source: The Third People's Hospital of Henan Province has been running around for a long time, and the patients who have been cured for a long time are unhappy. Liu Lao will listen carefully to the patient's condition and treatment process, understand the disease characteristics of each patient, introduce the treatment knowledge and operation principle of the main syndrome, and appease the patients' emotions. Mr. Liu comforted the crying patient. Image source: The Third People's Hospital of Henan Province According to him, this year, he also treated 9 patients with severe syndrome with poor postoperative effect after brain DBS, and all of them achieved the expected results after surgery. Liu Lao introduced that from the effective lifting of eyelid spasm, I saw the hope of overcoming major syndrome. This is only the first step, and there are still many problems to be solved. The popularity and development of new surgical methods benefit from the trust of patients and the support of hospital leaders. Photo source of Liu Lao's early surgery: The Third People's Hospital of Henan Province also applied for the patent of Liu Lao's surgical application system, and established a joint research group composed of ophthalmology, otolaryngology, stomatology, orthopedics, neurology, neurosurgery, psychology, electromyography, color Doppler ultrasound, nuclear magnetism and pathology, and jointly tackled the problem with the relevant teaching and research departments of Sanquan Medical College. The brand-new operation mode pioneered by Mr. Liu is also constantly being optimized and improved. This year's Physician's Day, the Third Provincial Hospital officially established a major disease diagnosis and treatment center in the East Campus. There is a medical team of 1 1 in this special ward, including 3 senior titles and 5 attending physicians, and more than half of them have graduate degrees. The surgical appointment in the ward has been arranged after May Day next year. At present, the hospital is also speeding up the training of new people, hoping to relieve the suffering of patients with severe syndrome as soon as possible and lead a normal life. Liu Lao also introduced his future plan with great interest, "Do a good job in relevant academic research." He said that the progress of scientific research will definitely bring about a technological leap. At present, many doctors all over the country are interested in this technology, and he has also called his colleagues who have contacted experts to set up a "light guardian" group, hoping that interested colleagues will participate and explore and study together. /kloc-More than 0/00 years ago, the French neurologist Henry Meg first described the major syndrome. One hundred years later, in China, there was such a doctor who dared to be the first in the world in order to bring light to patients with severe syndrome, relying on his excellent professional skills, his concern for patients' sufferings, and his heart of innovation and change. Thanks to the efforts of Mr. Liu and his team for many years, today's critically ill patients have a smile on their faces. Thanks to their persistence in never giving up easily, let the light re-illuminate the lives of patients with major syndrome. Editor in charge: Dr. Ding Lujin, scientific examiner: Chen Disclaimer: The above content comes from the Internet, and the copyright belongs to the original author. If there is any infringement of your original copyright, please let us know and we will delete the relevant content as soon as possible.