(1) Strengthen awareness of preventive biosafety management.
If the safety work is not taken seriously ideologically, the staff will inevitably fail to follow the rules and enforce the rules strictly. Therefore, to do a good job in dynamic safety management of biopharmaceutical enterprise employees, we must overcome the unscientific, simplistic, and formalized nature of safety management. Establish and improve safety regulations, formulate, improve and implement various safety management systems, and make rules and regulations formalized, standardized and effectively operated. Carry out different forms of safety inspections. Supervision, inspection, and implementation must be horizontal to the edge and vertical to the end, so as to encourage people to form a natural cycle of biosafety production activities in the biopharmaceutical industry.
(2) Strengthen the training of biosafety professional knowledge for practitioners.
The safety quality of employees is specifically reflected in their physiological conditions and their understanding of biosafety knowledge. For example, laboratory staff may have strong professional knowledge and professional experimental techniques, but they often neglect safe operations and personal protection, and accidents may occur. A researcher in a virus laboratory was infected with the hepatitis virus when he failed to wear gloves as required when cleaning waste from transport boxes. Therefore, safety publicity and education should be carried out frequently to make enterprise staff familiar with and master safety knowledge, operational skills and personal protection skills. Conduct regular safety training to improve the safety technical quality of enterprise staff and meet the objective requirements for safe operation in biological laboratories. Strengthen the cultivation of basic skills so that the majority of staff and technicians engaged in biopharmaceutical enterprises can become qualified professionals who understand both professional knowledge and laboratory biosafety.
(3) Establish and improve biosafety operating procedures and management systems for biopharmaceutical enterprises.
Establishing and improving laboratory biosafety operating procedures and management systems provides protection for laboratory workers from biological hazards. Since biopharmaceutical companies have different products, the biohazard factors involved are also different. Therefore, they must employ professional technical personnel according to the general requirements of biosafety and refer to the "Regulations on Biosafety Management of Pathogenic Microorganism Laboratories" and "Medical Safety Management Regulations" issued by the State Council. Waste Management Regulations", "General Requirements for Experimental Biosafety" and other regulations and documents, and formulate corresponding safety management systems and operating procedures based on the production characteristics of the enterprise.
Laboratory staff must be trained in biosafety protection related knowledge; laboratory access system: there should be a safety warning sign or a sign restricting the entry of unrelated persons at the entrance of the laboratory, and non-staff are not allowed to enter the laboratory Work areas in semi-contaminated and contaminated areas; safety inspection system: the door of the laboratory should be kept closed, animals unrelated to the laboratory are not allowed to be brought into the laboratory, good laboratory housekeeping behavior is observed, and edibles are prohibited from being placed in the same place as reagents or specimens. refrigerator.
According to the different sources of infection that laboratory workers are exposed to, different vaccines are injected regularly to enhance the physical fitness of laboratory workers; when laboratory workers enter the laboratory to work, they must The principle of protective equipment is to wear appropriate work clothes or protective clothing, shoe covers or special shoes; when performing operations that may come into contact with blood, body fluids and other potentially infectious materials, gloves (disposable gloves) should be worn, and when necessary Wear protective glasses and isolation gown.
Sandals, flip-flops, open-toed and woven shoes are strictly prohibited in the laboratory. Laboratory workers should wear latex gloves or double-layer gloves when they have skin damage or rash on their hands. It is strictly forbidden to leave the laboratory working area wearing laboratory protective clothing. When laboratory workers finish work or leave the laboratory, protective equipment should be disinfected and After removal, you must wash your hands afterwards, wash your hands with running water and soap under the sensor faucet, and use alcohol to wipe your hands; staff should follow biosafety requirements when collecting specimens, and all operators must wear work clothes, gloves, and masks. To overcome the fluke mentality of laboratory workers, we must strengthen the concept of universal prevention and use safe and reliable blood and body fluid supplies. Blood and body fluid specimens are the main specimens in the laboratory and are also the main substances with potential hazards in the laboratory. Safety issues are particularly important in blood and body fluid testing.
my country is a major country with hepatitis B infection and incidence. In recent years, the discovery and epidemic of AIDS have posed a great threat to inspectors who deal with blood and body fluids every day. Therefore, when collecting blood and body fluid specimens, try to reduce the possibility of direct or indirect contact of test personnel with these specimens. Vacuum blood collection tubes and disposable test tubes that match the instrument should be used. Try to avoid opening the lid to prevent the inhalation of microbial aerosols. The specimens are placed directly on the machine to form a fully closed system. Reduce the possibility of direct or indirect contact between inspection personnel and blood and body fluids during inspection processes such as body fluid collection, blood collection, transportation, processing, loading on the machine, and waste disposal.