Take a gun for example.
If a gun has a right-handed throw. A left-handed person would have trouble using it. The same goes for the bolt handle. A left-handed person would have trouble with an AK47. Because it requires the right hand to pull the bolt. It's not good for aiming. The M16 doesn't have this problem because the bolt handle can be pulled by both right and left hands. There is also the issue of center of gravity. The center of gravity of the gun should ideally be above the hand holding the gun. But everyone's arm length is different. So in order to be accurate, competition guns have to be adjusted to the center of gravity by adjusting the length and weight of the stock according to the competitor. In addition, it is important to avoid mishandling the gun. For example, the direction of the magazine and the way to fix it. If the magazine is not oriented in the right direction, it can be easily reversed. And so on and so forth. It can be said that the human-machine interface is the most important thing to consider when designing a product.