Autologous blood therapy is a method of treating diseases in which the patient's own blood is pumped into the blood bag, and the blood is filtered by using the strong oxidizing property of medical ozone to oxidize the fatty substances and proteoglycan complexes in the blood and kill disease-causing microorganisms, and then input into the human body.
Indications of autologous blood therapy:
1, ischemic and hypoxic diseases: cerebral thrombosis, cerebral infarction, angina pectoris, arrhythmia, bradycardia, diabetes mellitus gangrene and so on.
2, immune diseases: rheumatoid arthritis, rheumatoid arthritis, compulsive spondylitis, psoriasis, lupus erythematosus and so on.
3, inflammatory infectious diseases: necrotizing ulcers, animal bites, hard-to-heal wounds, burns and so on.
4. Atherosclerosis, vasculitis, etc.
5, metabolic diseases: gout, hyperlipidemia.
6, liver disease.
7, cancer. Regulate the body's antioxidant capacity
Ozone through the role of the body, an instant increase in the number of "free radicals", inducing and activating the body's antioxidant enzyme system, SOD and other free radical scavengers produced in large quantities to remove excessive free radicals, regulating the body's antioxidant capacity.
Ozone as a superoxide can activate the antioxidant enzymes, and play the role of "fighting poison with poison". This effect can remove the free radicals formed in the process of chronic inflammation, which can be used to treat chronic joint inflammation and vascular inflammation, as well as anti-aging effects.
Improve blood oxygen saturation and partial pressure of blood oxygen
Enhance the elasticity and dispersion of red blood cells, change the way of platelet polymerization and a number of blood rheology indicators, so as to improve its ability to pass through the capillaries, so as to enhance the ability to supply oxygen and energy to the tissues, activate the cellular activity, so that the metabolism of the tissues and the function of the restoration of
Oxidative degradation of petrochemicals
Ozone's strong oxidative decomposition ability can also oxidize and degrade petrochemicals, which can act on the wall of blood vessels and reduce atherosclerotic plaques. To a certain extent, it can also prevent the occurrence of stones.
Ozone therapy is effective for hyperuricemia and all diseases caused by increased uric acid.
Promotes the body's utilization of sugar
Promotes the tricarboxylic acid cycle, increases energy release, and restores the basal metabolism to a normal state. Therefore it can be used in the treatment of diabetes.
The therapeutic advantages for diabetes:
1, hypoglycemic effect;
2, improve blood rheology, prevention and treatment of complications;
3, comprehensive treatment of diabetic gangrene
Decomposition of wastes and poisonous substances produced in the metabolism
Ozone oxidizes and decomposes wastes and poisonous substances produced in the metabolism of the organism and facilitates their discharge The body. Ozone reduces lipids in the blood, not only for all kinds of hyperlipidemia, but also for all diseases caused by high fat amount, such as: chronic pancreatitis, kidney disease, liver disease, insulin-dependent diabetes mellitus, arteriosclerosis. Free fatty acids, cholesterol as well as cholesterol lipids in the serum are reduced after the use of ozone.
Effects of ozone on erythrocytes
Ozone enhances the metabolism of erythrocytes, such as activating the oxidative bypass of sugar (PPW), increasing the content of 2,3-DPG (2,3 diphosphoglycerate) in erythrocytes, and increasing the effect of oxygen supply to tissues.
- Ozone also increases the ATP content in erythrocytes, i.e. promotes erythrocyte metabolism.
- During the application of ozone for macroautohemotherapy treatment, there is a negligible amount of erythrocyte lysis. If the anticoagulant is berate, the amount of red blood cell lysis rises from a base value of 0.5% to 1.2%; if the anticoagulant is heparin it can reach 1.8%. Above a certain amount of ozone in the blood (up to 200 μg/ml), the percentage of cell lysis is even higher. Therefore, it is required that the concentration of ozone during treatment should not exceed 80μg/ml.
- Ozone can activate erythrocytes, increase the level of adenosine triphosphate (ATP) and 2,3-diphosphoglycerol (2,3-DGP), and increase the amount of oxygen carried by the blood and promote the splitting of hemoglobin, and reduce the binding capacity of oxygenated hemoglobin, thus improving the diffusion of oxygen from the blood to the cells.
- As a strong oxidizing agent, ozone has the potential to cause hemolysis. Especially in G-6PD deficiency (serosanguineous disease), due to the inability to produce enough reducing substances (lack of NADPH, so that the reduction of glutathione), encountered oxidizing agents, hemoglobin is destroyed and hemolysis. However, ozone has no pro-coagulant effect on platelets.
Auxiliary anti-cancer effects
The key to cancer development is hypoxia at the cellular level. The participation of ozone increases the oxygen content of blood and enhances its ability to supply oxygen directly to tissues, improves the hypoxic state of cancer cells, increases their sensitivity to radiation and reduces their resistance to chemotherapy. At the same time, it prompts the production of interferon, IL-II and tumor necrosis factor, which has a positive effect in tumor prevention and treatment.
Ozone treatment of liver disease: in recent years, after clinical biochemists and clinical pathologists, pharmacologists **** the same efforts, finally explained the mechanism of ozone treatment of hepatitis: for a certain amount of blood, the appropriate amount of ozone as a strong oxidant first by the blood glutathione and other reducing systems most of the After consumed by most of the reducing system such as glutathione in the blood, the remaining small portion generates a small amount of hydrogen peroxide and other active peroxides in the blood, and the latter two can induce various cellular components in the blood to produce various cytokines and active metabolites, thus triggering a series of immune response in the human body and playing a therapeutic role in viral hepatitis. Its specific mechanism is as follows:
1. Immunocidal effect: ozone and its active metabolites induce the human body to produce cytocidal T lymphocytes (CTL) and natural killer cells (NK), the use of the body's own immune function to attack and destroy hepatitis virus. It avoids the drawbacks of traditional virucidal drugs, such as lamivudine, which are prone to induce viral mutation and violent rebound after stopping the drug.
2. Immuno-inducing effect: Ozone and its active metabolites can enter the gap of immunoactive cells and intracellular, and activate the nuclear factor NFKB, thus further activating the cell nucleus mRNA, and promoting the synthesis of specific proteins, and finally releasing specific cytokines, which can be transferred to various lymphatic organs in the body along with the blood circulation to transmit information and activate other immunoactive cells to produce the immunity of hepatitis virus. The latter is transferred to various lymphoid organs in the body along with the blood circulation, transferring information and activating other immune-active cells, producing a progressive cascade of immune responses and exerting the anti-viral effect of ozone.
Ozone can induce the production of a variety of cytokines, such as various endogenous interferons (1FN-α, IFN-β, IFN-γ), interleukins (IL-2, 4, 6, 8, l0), tumor necrosis factor (TNF-α), granulocyte / monocyte colony-stimulating factor (CM-), and transforming factor. GM-CSF can increase leukocytes, while interferon can prevent viral replication, and endogenous interferon avoids the adulteration of synthetic interferon, thus eliminating its annoying side effects. At the same time, interleukin-2 and 1FN-alpha can activate the basic immunoregulatory functions and produce the following effects: activation of cytotoxic T-cells, macrophages, neutrophils and eosinophils, and activation of antibody-dependent cell-mediated cytotoxicity (ADCC), which ultimately kills virus-infected cells.
At the same time, ozone can also promote the antigenic expression of virus-infected hepatocytes, so that some hidden hepatitis, drug-resistant hepatitis and hepatitis viral carrier state can obtain good therapeutic effect. In addition, the pathogenesis of fulminant hepatitis, which has a very high morbidity and mortality rate, is due to an over-excited autoimmune response, resulting in the destruction of a large number of hepatocytes in a short period of time. The ozone-induced IL-10 and TGF-βl can inhibit the excessive immune activation, so that the immune response can be carried out in an orderly manner, so that the patients with fulminant hepatitis can obtain a more satisfactory therapeutic effect.
3. Hepatoprotective and hepatoprotective effects
The hepatoprotective and hepatoprotective effects of ozone are mainly reflected in the promotion of the oxygen-carrying capacity of hemoglobin, which improves the supply of oxygen to the liver, and at the same time, activates the free radical scavenging system of the liver, which improves the antioxidant capacity of the liver. Ozone activates all erythrocyte metabolism by activating the pentose phosphate pathway in erythrocytes. Ozone induces an increase in ATP in erythrocytes, which improves the mechanical resistance of the erythrocyte membrane and improves blood rheological properties: ozone also induces the production of 2,3-DPG (2,3-diphosphoglycerol), which promotes the release of oxygen from oxygenated hemoglobin into the tissues. Animal experiments have shown that blood oxygen
partial pressure in the intrahepatic portal vein increased by 50% in rats that were executed immediately after rectal instillation of ozone.
The therapeutic dose of ozone into the human body, can produce - a certain dose of free radicals, activate the body's antioxidant enzyme system, mainly superoxide dismutase, catalase and glutathione peroxidase, to protect the body from peroxides and free radicals, and at the same time, can be scavenging the body of excessive oxidized free radicals, reduce the burden on the liver, and promote the recovery of liver function in a short time. It can also remove excessive oxidized free radicals from the body, reduce the burden on the liver, promote the recovery of liver function, and make the patient feel less symptomatic and better in a short period of time. The role of ozone in promoting free radical scavenging is also widely used in Europe in the field of anti-aging, geriatrics and sports medicine.