The greatest achievements in medicine in the 21st century are: the basic research and clinical translation of Langerhans cell biology function, the creation, implementation, and leadership of China's blood purification medical quality management and control system, and the molecular genetics of spinal deformity research and clinical application.
Achievement 1: Langerhans Cell Biology Functional Basic Research and Clinical Translation.
Internationally, Langerhans cells were found to be important immune cells for the first time; the origin, distribution, conversion, antigenic phenotype, immune function and pathophysiological function of Langerhans cells were systematically researched; controlled-wave infrared dermatological warming therapy equipment was invented and designed, and the innovative clinical intervention treatment program "3+2 warming therapy" was proposed. "
Achievements
Achievement 2: Creation, implementation and leading of medical quality management and control system of blood purification in China.
The first three-level management real-time online blood purification case information registration system combining blood purification diagnostic and treatment technology and medical quality control, the first "Standard Operating Procedures for Blood Purification" in China, as well as a number of guiding recommendations for the prevention and control of blood purification neocollagenesis, which have significantly improved China's blood purification diagnosis and treatment, as well as the level of medical quality control.
Achievement 3: Research on molecular genetics and clinical application of spinal deformity.
Leaded the establishment of the "Systematic Analysis of Spinal Deformities and Associated Comorbidities" research collaborative group, and constructed China's first international leading genetic research system on skeletal deformities, which revealed the most important genetic etiology of congenital scoliosis, and defined a brand new subtype of congenital scoliosis, which was called the "Chinese model". "Chinese model".
Achievement 4: Revealed for the first time the laws of genetic and epigenetic regulation of human germ cells and embryonic development, giving birth to the world's first in vitro fertilization with high-throughput sequencing for single-gene genetic diseases and chromosomal abnormality screening.
Revealing the mechanisms of gene expression and epigenetic regulation during human reproductive development, and completely mapping the high-precision single-cell transcriptome of human germ cells and early embryos; completing high-precision whole genome sequencing of individual human oocytes through the technique of "single-cell genome amplification"; and successfully sequencing the world's first high-throughput sequencing test tube baby for single-gene genetic diseases and chromosomal abnormality screening. The world's first in vitro fertilization with high-throughput sequencing for single-gene genetic diseases and chromosomal abnormality screening was born.