nmn on the role of the femur, exactly nmn side effects will not affect the appetite, the truth came , although nmn is now well known to many people, but for its efficacy is still in the increasingly explored, some time ago there are scientists have found that nmn can be directly promote the expansion of mesenchymal stem cells to stimulate the differentiation of osteoblasts and inhibit the adipocyte differentiation and slow down bone loss. In short, nmn makes people grow more bones and less meat. The researchers then explored the effect of nmn on the differentiation of MSCs, which can be directed to differentiate into osteoblasts, adipocytes and chondrocytes under specific conditions in vitro, suggesting that nmn can stimulate osteoblastic differentiation and inhibit adipocyte differentiation. Then the question came many people responded that will not since it is on the differentiation of fat cells, then will not affect the appetite? In fact, meow sister here to remind everyone, now with the expansion of the NMN market, mixed, if stepped on the pit, the side effects are unquestionable, so this time how to distinguish it? Today to share with you "NMN quality management international top ten core standards", against, to see exactly how to choose.
NMN in terms of choice, need to pay attention to a few points: 1, origin (the United States, France, Japan, Hong Kong) 2, purity (70% 80% ?98% ?99% for the optional index) 3, the content (3,000, 6,000, 9,000, 12,000, 12,000 at present, the optional index) 4, the international certification (single-country authentication and dual-country authentication, dual-country authentication of the dual dual double trial, is currently safe and reliable) 5, international certification (single country certification and dual-country authentication, dual double trial. Is currently safe and reliable) 5, production process 6, quality management, from these aspects of the rational choice of nmn, is the formal scientific way!
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Scientific experiments have proved - nmn for femur
As the saying goes, we and our arteries are as old as we are, so reversing the aging of the blood vessels is the key to restoring youthful vitality?
In this study, the answer seems to be yes, at least in rats.
"We found a way to reverse vascular aging . By increasing the presence of a certain natural molecule in the body that increases the body's physiological response to exercise," said David Sinclair, chairman of the department of genetics at Harvard Medical School and director of the Center for Anti-Aging Research.
As we age, we become weaker. A series of physiological changes - some subtle, some drastic - contribute to this inevitable decline.
As we age, our tiny blood vessels shrink and die, resulting in reduced blood flow and weakened tissue oxidation. Aging blood vessels are responsible for many conditions such as muscle loss, impaired wound healing and overall weakness.
Scientists already know that reduced blood flow to organs and tissues leads to toxin accumulation and low oxygen levels. Endothelial cells used to line blood vessels are essential for the production of new blood vessels. These new blood vessels supply oxygen- and nutrient-rich blood to tissues.
But as these endothelial cells age, the blood vessels shrink, new blood vessels cannot form, and blood flow to most parts of the body gradually decreases. This phenomenon is particularly evident in skeletal muscle, which is highly vascularized and depends on a robust blood supply for its function. In a series of experiments, the team found that blood flow decreases when endothelial cells begin to lose a key protein known as sirtuin1 or SIRT1. Supplementation with NMN increased NAD+, stimulated SIRT1, and restored endothelial cell growth.
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NMN quality management of the international top ten core standards
1, quality management system: NMN must comply with the "OULF" European Union law testing qualified and "FDA U.S. Food and Drug Administration" certification, in addition to the labeling of the name of the goods, but also need to label all the ingredients content and NMN purity of the word, need to label the country of origin and distribution The country of origin and the country of distribution need to be labeled.
2, production process management system: high and production process affects NMN live form. It is not recommended to use "chemical extraction method" to avoid chemical residues.
3, content management system: relative NMN content mg/bottle ≥ 12000, absorption directly to the small intestine, enteric absorption is 20% of gastric absorption.
4, efficiency management system: to examine the authenticity and purity of raw materials.
5, absorption management system: the use of enteric absorption, enhance the absorption rate and absorption threshold.
6, activity management system: the number of molecules that convert NAD+ per unit dose (per 100 grams), NMN molecules can easily pass through the cell membrane and enter the inside of the cell to increase the NMN content of the human body within 15 minutes and rapidly increase the level of NAD+.
7, the use of the scope of management system: adults ( pregnancy, lactating women are prohibited ).
8, safety management system: production process, raw material collection, "OULF" OULF standard basic system, factory OULF testing, microbial heavy metal exceeding the standard strict examination, generation of technical work of science.
9, raw material management system: most NMN companies are single-country certification, and the current dual-country certification of raw materials management is more rigorous and AnTsuen, such as ACMETEAW + NMN, belongs to the French and U.S. dual-country certification standards of the product.
10, multi-country supervision and management system: "France" "U.S." two countries double supervision. The U.S. FDA sets standards for GMP of dietary supplements, and the European Food Safety Authority (EFSA) regulates the management of food supplements in the European Union.
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NMN quality management of the international top ten core standard details:
One of the quality management system:
NMN must be in line with the "OULF" European Union law testing and "FDA U.S. Food and Drug Administration" certification, in addition to the labeling of the name of the product, but also need to label all the ingredients content and NMN purity words! In addition to the name of the product, it also needs to be labeled with the content of all ingredients and NMN purity, as well as the country of origin and distribution.
Second, the production process management system:
Does the production process also affect the health of NMN on the body?
1, raw material level that is medical grade raw materials, generally not as direct oral use;
2, ACMETEA W + NMN "cold-pressing biological enzyme" production technology, can make NMN at low temperatures to maintain inactivation, and compression to become a stable capsule, the purity of the NMN will be increased to 99%, more conducive to the preservation and distribution of NMN, and also more conducive to the preservation and distribution of NMN. 99%, more convenient for preservation and human absorption, in order to maximize the bioavailability of cofactors to support human metabolism, without the need to convert to nicotinamide ribonucleoside (NR) through the SLC12A8 gene, and directly and rapidly converted to NAD + to replenish the body's NAD + level, which is the first solution for the preparation of NAD +.
In addition, NAD+ is the first coenzyme that starts the tricarboxylic acid cycle and participates in the four steps of the tricarboxylic acid cycle, which is the essential aerobic respiration and energy supply cycle of the human body, and participates in 95% of the energy supply of the human body.
The level of NAD+ has a direct impact on the efficiency of the tricarboxylic acid cycle, which determines the energy production of the human body.
The tricarboxylic acid cycle is the main pathway for human beings to obtain energy, and it is the most effective way for human beings to metabolize organic sugars, mainly in the mitochondria. Tricarboxylic acid cycle is the main synthesis product is ATP - adenosine triphosphate, ATP organisms the most direct source of energy. Without the tricarboxylic acid cycle, human cells will not be able to obtain energy, and human beings will not be able to survive.
Three, content management system:
On the issue of NMN daily dosage, the real baffled in the scientific research level of academic support for a statement is that the human body's dosage of 8 mg of NMN per kilogram of body weight per day, so that the conversion into a 70 kg adult, then, the daily recommended dosage of 560 mg or so, the daily absorption, consumption, age and other issues to consider. The problem of comprehensive consideration, ACMETEAW + NMN content mg / bottle ≥ 12000 is able to ensure that the above daily consumption and body reserves.
The mitochondria in human cells is the power plant of the cell, coenzyme I is the mitochondria in the aerobic oxidative metabolism of the tricarboxylic acid cycle to generate the energy molecule ATP important coenzymes, and its transfer of hydrogen and electrons to maintain the normal aerobic respiration, so that the human body obtains three major categories of nutrients, sugar, fat and protein, through oxidation into the human body's energy requirements and other metabolic activities required for the material.
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Currently each bottle of NMN total content of the different. NMN3000 is a bottle of content of 3000mg; NMN6000 is 6000mg/bottle; NMN9000 is 9000mg/bottle; NMN12000 is ACMETEAW + 12000mg/bottle, currently ACMETEAW+NMN12000 content and purity are the highest. NMN12000 has the ability to enhance the level of activation within the tissue, to promote the NMN12000 content quickly into the cells of various organisms, increase the number of NMN to inhibit aging, so that the aging organs recovery, our body is gradually losing function, timely repair. Successfully let the cells reappear alive.
Four, efficiency management system:
Through ACMETEAW + NMN can avoid the edge of the diminishing effect, control the product to maintain the level of efficacy for a long time; to enhance the efficiency of the tricarboxylic acid cycle, so that NMN in the human body to produce more efficacy, but also to avoid the uncontrolled effects of overdose intake; the ability to maintain the rate of absorption, and thus reduce the impact of the human body.
NMN regulates cell survival and death, and maintains the redox state. Recent studies have found that by regulating the level of NMN in the organism, repairing damaged cells in a timely manner, slowing down cell mutation and aging, it also slows down the decline of the human body and reduces diseases, thus achieving the purpose of anti-aging. For cardiovascular and cerebrovascular diseases, neurodegenerative diseases and aging degenerative diseases, etc. have better metallurgical and repair effects; in addition, ACMETEA W + NMN can also participate in and regulate the body's endocrine, play a role in protecting and repairing the function of pancreatic islets, increase the secretion of insulin, prevention and treatment of urolithiasis and obesity and other metabolic diseases.
V. Absorption management system:
Whether the effect of NMN is obvious, the average person on the absorption of nutrients is only 10-20%, the NMN is no exception, when the purity of the NMN increased to 99%, through the ACMETEA W + NMN technology to stabilize the MNM in the stomach in the form of a rapid transmembrane, to avoid destruction of the gastric acid, will be absorbed by ten to twenty-fold enhancement through the Enteric absorption, small intestinal cells on the slc12a8 transporter is specifically responsible for the transfer of NMN into the cell, and then with the blood circulation, will be the body's various organs and tissues of the cell utilization, to ensure that the clinical ACMETEA W + NMN data true.
Currently, several clinical trials of NMN as a treatment for disease have been completed in the first phase of human clinical trials, including Harvard Medical School, and all of them proved to be safe for human beings. In previous animal tests, researchers used 50 times the normal dose and fed mice for six months without finding any negative effects. The U.S. FDA has also certified NMN's safety as a food additive ingredient.
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At the age of 60, the body's coenzyme 1 (NAD+) content is less than one-fourth of what it was at the age of 20, which triggers a variety of aging symptoms in the body, such as memory loss, weakening of cardiovascular function, immune system decline, poor sleep quality, decreased energy, constipation, hair loss and loss of appetite. In the past 3-4 years, the most authoritative international academic journals Science, Nature and Cell have continuously published human and animal studies, which have repeatedly proved that supplementation of NMN can effectively increase and restore the level of Coenzyme I in the body, significantly slow down the aging process and prevent various neuron degenerative diseases such as Alzheimer's disease, which can fundamentally regulate and improve the various symptoms of aging. Other studies have addressed cancer, infertility, obesity, cerebral hemorrhage, heart failure, heart damage, vascular aging, acute kidney failure, diabetes, etc., demonstrating the multifaceted medical treatment and potential of NMN supplementation. ?
The key to why you need to take NMN, Sirtuins are a group of proteins that can reverse DNA damage, it reverses aging within your cells at the cellular level, this is why ACMETEAW + NMN has the potential to enhance your ability to age, Sirtuins need two things to facilitate the start up, first they need enough fuel, then they need someone to to step on the gas at startup, that fuel is NAD+, that's where ACMETEA W+NMN comes in, Sirtuins is what we're trying to wake up to, that's what really helps you with anti-aging, to start up Sirtuins proteins you need fuel, that's NAD+, NMN can provide the fuel but right now your body produces its own NAD+, so why do you need to take NMN to boost your NAD+ levels, and here's the key part, as you get older your NAD+ levels start to drop, which means there's not enough fuel to kickstart your Sirtuins, and that's why when you're getting a little bit older you need to boost your NAD+ levels, and so you do that by taking ACMETEA W + NMN to supplement with NAD+, if you're over 30 it's recommended that you take 1 gram of ACMETEA W+NMN every morning it gets into the cells, it gets into your bloodstream, and your cells can absorb it in that will provide your cells with all the fuel they need to kickstart your Sirtuins.
Sixth, living form management system:
ACMETEAW+NMN converts the number of molecules of NAD+ per unit dose (per 100 grams), the concentration of NMN in the blood gradually rises in 10 minutes, and within 30 minutes, NMN enters multiple tissues with the bloodstream circulation and synthesizes NAD+ in the tissues to elevate the level of NAD+.
In the past 3-4 years, Science, the most prestigious international academic journal, has continuously published human and animal studies, which have repeatedly proved that supplementation of NMN (ACMETEAW+NMN) can efficaciously increase and restore the level of Coenzyme I in the body, significantly slow down the aging process, and prevent Alzheimer's disease and other neuronal degenerative diseases, and thus fundamentally regulate and improve the various symptoms of aging. The research has also been done on cancer, infertility, and other diseases. Other studies have also addressed cancer, infertility, obesity, cerebral hemorrhage, heart failure, heart damage, vascular aging, urolithiasis, etc., suggesting that supplementation with NMN has multifaceted medical grade and human health potential.
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Seven, the use of the scope of management system:
1. the elderly, used to assist in the improvement of various geriatric diseases;
2. middle-aged people, dissolve or alleviate a variety of sub-health problems, such as chronic fatigue, poor sleep, eyesight loss, etc.;
3. stay up all night to accelerate the recovery of the organism;
4. test takers, to improve stress resistance and keep a clear mind;
5. high radiation dose, such as radiology doctors and nurses, aircrews, to improve the repair of damaged genes due to radiation;
6. cancer patients, to help repair genes in patients after radiotherapy to improve the immune . Cancer patients, to help patients after radiotherapy to repair genes, improve immunity, accelerate the recovery of the body;
7. Fitness, to accelerate muscle growth;
8. Athletes, to enhance the energy level and reaction speed;
9. Alcohol drinkers, to improve the ability to detoxify alcohol, to protect the liver, to repair the genes of the toxicity of the damage caused by acetaldehyde;
10. Smokers, to reduce the addiction to cigarettes;
11. Levels, change the mood, increase the blood supply to the brain, and moderate depression caused by brain decline;
12. middle-aged and elderly women, change the skin health, delay skin aging;
eight, An Tsuen management system:
Production process, ACMETEA W + NMN's "Cold-pressure Bio-enzymes
Nine, raw materials management system:
Numerous NMN manufacturers, raw materials in a single country certification, while the real level of AnTsuen is required to dual-country certification, ACMETEA W + NMN products, belonging to the French and U.S. dual-country certification standards. In terms of raw materials, ACMETEA W+NMN products are certified by both the French and American authorities.
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Ten, multinational supervision and management system:
ACMETEA W+NMN meets the U.S. FDA standards for dietary supplements GMP regulations, GMP is a set of mandatory standards applicable to the pharmaceutical, food and other industries, requiring companies to meet hygiene standards in terms of raw materials, personnel, facilities and equipment, production process, packaging and transportation, quality control, etc. in accordance with relevant national regulations. In accordance with the relevant national regulations to meet the health and quality requirements;
ACMETEA W+NMN complies with the European Union Food Safety and Security Agency (EFSA) European Union food supplements and "OULF" OULF law management related regulations. The aim is to ensure that the nutritional and health information provided to consumers on food packaging is accurate and reliable so that consumers do not misinterpret it. The basic purpose of the regulation is to provide legal and regulatory harmonization of nutritional and health claims for food and related functional foods among EU member states in terms of labeling, presentation, advertising, etc., so that related food products can circulate freely among member states;
The above is my about "analyze the role of NMN on the stock of meat, exactly the side effects of NMN will not affect the appetite "Shared, as a dietary supplement, anzheimer is the focus of our concern, some people will steal the beam, and even fail to meet the said standard, so in the choice of time must be rational, in accordance with the choice of industry standards to distinguish well, to avoid entering the pit,