1. Experimental research on hydrogen cancer control
In 2012, Kawai et al. in Japan reported that the fatty liver and hepatocellular carcinoma model of STAM mice was induced by MCD diet, and drinking water was injected as a blank control group. The elevation of transaminase is the least obvious; ② hydrogen-rich water is more effective in reducing the volume of liver tumors, and has an antagonistic effect on liver cell oxidative stress, apoptosis, inflammation, and tumorigenesis.
From the mechanism point of view: ① Hydrogen water is more effective in antioxidant and preventing hepatocellular carcinoma; ② Hydrogen water significantly down-regulates lipid metabolism related genes in model animals; ③ Hydrogen water is effective in protecting DNA oxidative damage; ④ Hydrogen water's mechanism of action also includes the inhibition of TNF-α201 and IL-6121 in the apoptosis of hepatocyte cells and the formation of fatty liver; ⑤ PCNA expression level in hepatocytes of hydrogen water group was significantly reduced, indicating that PCNA expression level in hepatocytes was significantly reduced, indicating that PCNA expression level in liver cells was significantly reduced. expression level was significantly reduced, indicating that hydrogen water has a strong effect against cell proliferation.
In 2013, Li et al. from China reported that the prevention of iron nitrilotriacetate (Fe-NTA)-induced kidney damage and kidney cancer rat model, the results found that: ① the degree of kidney damage in the hydrogen-rich water group of animals was significantly reduced, and the serum creatinine and urea nitrogen levels remained normal. ②Principle: i. Reduce the formation of lipid peroxidase and peroxynitrate to inhibit oxidative stress; ii. Enhance the activity of catalase to restore the function of mitochondria in kidney cells; iii. Reduce the aggregation of macrophages in the kidneys to inhibit inflammation. ③ Inhibit the expression of VEGF and PCNA in kidney cells and inhibit STAT3 phosphorylation. ④ The incidence rate of kidney cancer in animals in the hydrogen-rich water group (22%) was lower than that in the control group (54.8%), and the rate of incidence was also slower than that in the control group.
From the mechanism of renal cancer: ① Hydrogen water can reduce the iron content in the kidneys of model animals, and at the same time reduce the level of OONO- and MDA in the kidneys; ② The expression of HO-1 gene in the kidneys of animals with hydrogen water is significantly reduced; ③ The significant reduction in the expression of IL-6 and MCP-1 in the kidneys of model animals drinking hydrogen-enriched water best reflects the anti-cancer ability; ④ The consumption of Vitamin C in the kidneys of model animals drinking hydrogen-enriched water best reflects the anticancer ability; ④ The consumption of Vitamin C in the kidneys of model animals is significantly reduced. The decrease of VEGF expression in the kidneys of model animals after drinking hydrogen-enriched water may be another mechanism of hydrogen; ⑤ The decrease of STAT expression in the model animals after hydrogen water treatment and the resultant decrease of IL-6 level should also be a mechanism of hydrogen action.
2. Experimental study of hydrogen cancer control