Most people don't know that lung cancer has ranked first in cancer deaths in China for more than ten years. More people mistakenly believe that smoking is the only risk factor for lung cancer. In fact, many lung cancers occur in people who do not smoke. Besides smoking, air pollution and heredity are carcinogenic factors.
The leading killer of patients with non-small cell lung cancer in China
Lung cancer can be divided into small cell carcinoma and non-small cell carcinoma. Small cell carcinoma is closely related to smoking, but it only accounts for 10% of the total number of lung cancer patients. Non-small cell carcinoma is the most common type of lung cancer in China, and adenocarcinoma is the most common type of lung cancer. Tumors are usually located around the lungs, grow slowly and have almost no symptoms in the early stage, so they are often ignored by patients.
New choice of irreversible targeted drugs for lung cancer treatment
The treatment of lung cancer is nothing more than surgery, radiotherapy and chemotherapy. Targeted drugs provide patients with another treatment option. Targeted drugs, as the name implies, act on specific gene mutations related to cancer cells and inhibit tumor growth. For example, if the mutation of human epidermal growth factor (EGFR) is positive, they can be treated with targeted drugs, and one of them can completely bite the four receptor families of EGFR without easily missing the target, which is called irreversible targeted drugs. When EGFR mutation is positive in more than half of lung adenocarcinoma patients in Taiwan Province province, irreversible targeted drugs can effectively inhibit tumor growth.
Most targeted drugs are monoclonal antibodies, that is, they can only act on one target, while irreversible targeted drugs have the function of multiple targets and can act on multiple targets to inhibit tumor cells. Taking targeted drugs for lung cancer as an example, irreversible targeted drugs can act on four EGFR receptor families at the same time. When the drug binds to the receptor, it can continue to adhere to the receptor and block the signal transmission path of cancer cells, which not only improves the curative effect, but also prolongs the patient's life without deterioration 13 months.
The irreversible targeted drug Najianbao is preferred as the first-line treatment.
Clinically, a 65-year-old patient with lung adenocarcinoma was admitted to the hospital. He didn't smoke before, but he still suffers from lung cancer. At first, he resisted biopsy for fear that chemotherapy would affect his quality of life, until he returned to the clinic a few months later because his symptoms worsened. By then, the tumor had become twice as big, 6 cm in size, and had metastasized to his brain. It was confirmed that the EGFR test was positive, and his daughter encouraged him to accept irreversible target drugs. After treatment, the lung tumor shrank in a short time, and no brain metastasis was found at present. Another 90-year-old patient originally planned to receive palliative care after learning that he had lung cancer. However, due to the irreversible targeted drug therapy, bone metastasis has been controlled, the original severe bone pain has been completely relieved, and lung tumors have also shrunk. It shows that the advent of irreversible targeted drugs is a great boon for doctors and patients.
Every minute counts for the treatment of advanced lung cancer, so it is necessary to master the correct medication in prime time, just like the first place in the relay race always bears a heavy responsibility, and running fast can open the distance at the first time. The medical insurance payment standard has approved the irreversible target drug for the first-line treatment of advanced lung adenocarcinoma, but it must be used at its own expense after the second line, and the treatment choice of patients with advanced lung adenocarcinoma has increased the powerful weapon.
After the advent of irreversible targeted drugs, we have a better weapon against lung cancer, but we still can't ignore the importance of early detection and early treatment, including chest X-ray and CT, which are helpful for early detection of cancer. Patients should also trust doctors and modern medicine, don't give up hope easily, and master the first-line prime time for treatment. I believe it will effectively prolong the survival time and give consideration to the quality of life. (Article provided/Chen Junrong, attending physician of thoracic department of Yida Cancer Treatment Hospital)
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