First, let's talk about the efficacy of aspirin. In the prevention of cardiovascular diseases, the main pharmacological action of aspirin is its anti-platelet aggregation effect. In the process of the occurrence and development of atherosclerosis, if unstable plaque appears on arterial blood vessels, when the plaque ruptures, it will cause platelet aggregation, and the aggregated platelets, together with other coagulation substances, will easily form thrombus and cause vascular blockage. Aspirin can reduce the platelet aggregation, and when the plaque ruptures, it will reduce the risk of thromboembolism caused by platelet aggregation.
Aspirin has definite pharmacological effects of antiplatelet and prevention of thrombosis, but in the process of long-term medication, the safety of medication is also worthy of attention. In the process of taking aspirin for a long time, the main drug safety risk lies in its risk of bleeding caused by platelet aggregation. This anti-platelet aggregation effect of aspirin is a sharp weapon to prevent arterial thrombosis, but if there is a bleeding problem, such as gastrointestinal bleeding, this effect of aspirin is unfavorable.
Taking aspirin for a long time, we say that the most important thing to pay attention to is the risk of gastric bleeding. This risk comes not only from aspirin's resistance to platelets, but also from aspirin itself, which is a drug with strong irritation to the stomach. If taken directly, aspirin will directly stimulate the gastric mucosa. Therefore, for friends who need to take aspirin for a long time for cardiovascular disease risk prevention, it is recommended to choose enteric-coated tablets to reduce the direct stimulation of drugs on gastric mucosa. Of course, aspirin is irritating to the stomach. Aspirin can not only stimulate the drug itself, but also inhibit the synthesis of prostaglandin, which is an important substance to maintain the health of gastric mucosa. Therefore, even taking aspirin enteric-coated tablets, we should pay more attention to the risk of adverse reactions of gastric bleeding that aspirin may cause.
So how should I take aspirin enteric-coated tablets? It is not wrong to suggest taking it on an empty stomach. Some friends may take it for granted that this medicine stimulates the stomach, and of course they should take it after meals to reduce the irritation to the stomach. But for enteric-coated tablets, we wrap an enteric coating on the outer layer of the tablets so that the medicine will not dissolve in the stomach. When the drug enters the intestine, the enteric coating begins to melt and the drug begins to dissolve and absorb, which greatly reduces the direct stimulation of the drug to the gastric mucosa.
So what is the most important thing about enteric-coated tablets? For enteric-coated tablets, the most important thing is to reduce the retention time in the stomach as much as possible and enter the intestine as soon as possible. On the one hand, it is beneficial for the drug to be absorbed as soon as possible, and on the other hand, it can reduce the dissolution caused by the long retention time of the drug in the stomach. Therefore, taking aspirin on an empty stomach is certainly a better choice under such a premise.
Aspirin enters the stomach on an empty stomach and will quickly enter the intestine through the stomach, reducing the retention time of drugs in the stomach. Usually on an empty stomach, enteric-coated tablets will leave the stomach and enter the intestine within half an hour, and begin to dissolve and release. However, if aspirin enteric-coated tablets are taken after meals, drugs and food will be mixed together and enter the intestine with the emptying of the stomach, which generally takes 1 ~ 2 hours to enter the intestine.
For aspirin enteric-coated tablets, because the enteric coating protects our gastric mucosa from the direct stimulation of aspirin, there is no need to consider the problem of reducing gastric irritation after eating. Choosing to take medicine on an empty stomach can better reduce the residence time of the medicine in the stomach and make it enter the intestine as soon as possible. On the one hand, it can take effect faster, on the other hand, it can reduce the direct stimulation of drugs. As for the inhibition of gastric mucosal stimulation caused by prostaglandin synthesis by aspirin, its pharmacological effect is inevitable. Whether eating or fasting, there is this risk. What we can do is to understand this risk and pay attention to observe and control the possible bleeding risk during taking the medicine. If there is a problem of gastrointestinal bleeding, stop taking medicine and seek medical advice in time.
Finally, to be more verbose, in the process of long-term use of aspirin, the benefits of cardiovascular disease prevention to patients with cardiovascular diseases are enormous, and the risk of adverse reactions causing gastrointestinal bleeding is different, because individuals have different constitutions, different stomach health conditions and different drug tolerance. It is only a certain probability, but it may not happen. Therefore, for people who take aspirin for a long time, don't take it because of a possible risk. Just give up the clear health benefits, don't eat indiscriminately, but insist on rational drug use according to the doctor's advice, pay attention to the possible risk of adverse reactions, and do a good job of observation and monitoring.
Aspirin is the cornerstone drug for the treatment of cardiovascular diseases, which is mainly used to prevent the first occurrence and recurrence of myocardial infarction and cerebral infarction, and has obvious benefits after long-term use. However, with the extension of medication time, the incidence of adverse reactions of aspirin gradually increased, especially gastrointestinal adverse reactions, which is the main reason for reducing patients' tolerance. So will aspirin enteric-coated tablets reduce gastrointestinal damage when taken on an empty stomach? Next, medical science will analyze it for you.
Aspirin has many pharmacological effects, and its pharmacological effects are closely related to dosage. To prevent myocardial infarction and cerebral infarction, the pharmacological effects of low-dose aspirin are mainly used. The so-called low-dose aspirin means that the daily dose is 75-325mg. Aspirin in this dosage range has anti-platelet aggregation effect, which can prevent thrombosis and reduce the risk of cardiovascular and cerebrovascular blockage. Aspirin also increased gastrointestinal mucosal injury during use, and its injury mechanism is closely related to aspirin's inhibition of cyclooxygenase-1 activity. In particular, aspirin in ordinary dosage forms begins to dissolve in the stomach, so the damage of gastric mucosa is more prominent, and symptoms such as loss of appetite, epigastric pain and black stool may appear. But aspirin enteric-coated tablets are completely different. Enteric-coated tablets are coated with enteric coating, which is almost insoluble in acidic environment (stomach) for a short time, but only dissolves and releases aspirin in alkaline environment (intestine), thus reducing the damage of aspirin to gastric mucosa, reducing the incidence of adverse reactions and increasing the tolerance of patients.
Although aspirin enteric-coated tablets are acid-resistant and will not dissolve in the stomach for a short time, if they stay in the stomach for too long, the outer enteric-coated tablets will still be corroded and dissolved by gastric acid. Therefore, aspirin enteric-coated tablets should be taken on an empty stomach and can be taken half an hour before breakfast. If taken after meals, gastric acid secretion will increase, and it will take 3-4 hours for the food in the stomach to be completely discharged into the intestine. After 3-4 hours of gastric acid corrosion, the enteric coating may have been destroyed by gastric acid, and aspirin will be released in the stomach, which will aggravate the damage of gastric mucosa. Therefore, taking aspirin enteric-coated tablets on an empty stomach can reduce gastric mucosal damage.
To sum up, taking aspirin enteric-coated tablets on an empty stomach can reduce its dissolution in the stomach, thus reducing the damage of gastric mucosa and increasing the tolerance of patients. Thank you for reading!
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When to take aspirin is indeed the most concerned issue for the masses, not only the patients themselves, but also the patients' families. In particular, the question whether aspirin should be taken before or after meals is consulted almost every day. Everyone is mainly afraid of taking aspirin to stimulate the stomach and stomach, and is afraid of side effects such as gastric bleeding caused by aspirin. Dr. Zhang will talk to you about this problem today, hoping to help you.
Aspirin is a non-steroidal anti-inflammatory drug synthesized by German Hoffman under the guidance of his teacher eichengreen one hundred years ago. In the past century, aspirin, a classic nonsteroidal anti-inflammatory drug with antipyretic and analgesic effects, has been gradually found to have more functions, such as low-dose anti-platelet aggregation and treatment of cardiovascular and cerebrovascular diseases. Some studies also show that long-term oral aspirin can reduce the incidence of colon cancer.
At the same time, human beings are constantly improving the dosage form of aspirin, such as making aspirin into enteric-coated tablets, which are often seen in pharmacies, so that the stimulating effect of aspirin on digestive tract, especially stomach, is much less. But, as everyone asked before, when should I take aspirin? This is really a problem.
In fact, the commonly used dosage forms of aspirin, namely aspirin tablets or aspirin effervescent tablets, are recommended to be taken after meals in order to reduce the irritation of aspirin to the stomach. Aspirin enteric-coated tablets disintegrate in alkaline environment and are stable in acidic environment, so they can be coated accurately. The stomach belongs to acidic environment, and aspirin enteric-coated tablets will not disintegrate, so try to take it orally when the acidic environment in the stomach is high before meals, in order to reduce the stimulating effect of aspirin on the stomach.
These are the reasons why taking some aspirin on an empty stomach will cause less irritation to the stomach. I hope everyone can gain something after reading this article.
Aspirin is one of the widely used drugs in clinic, which has the effect of anti-platelet aggregation. At present, it is mainly used for the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases. Aspirin, as a medicine, should be used under the guidance of professional doctors to maximize its efficacy and reduce the occurrence of adverse drug reactions.
Aspirin mainly includes common type and enteric-coated type, among which the common type has a direct stimulating effect on gastric mucosa, so it is recommended to take it after meals to reduce the occurrence of stomach discomfort. Compared with the common type, the enteric type has an acid-resistant and alkali-resistant shell, which does not dissolve in the stomach, but only dissolves in the alkaline environment of the intestine. Therefore, it is recommended to take it on an empty stomach before going to bed or in the morning.
Taking enteric-coated aspirin on an empty stomach will do less harm to gastric mucosa. If we take it after meals, it will increase the retention time of enteric-coated aspirin in the stomach, and the PH value in the stomach will increase after meals. Taking aspirin after meals will lead to early decomposition and increase the occurrence of gastrointestinal discomfort.
When aspirin is used for the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases, it is recommended to take 75~ 100mg daily and stick to it for a long time, so as to exert the continuous anti-platelet aggregation effect and achieve the effect of preventing thrombosis. In the process of use, we should also pay attention to monitoring whether there are any side effects such as gastrointestinal discomfort, bleeding, allergies, liver and kidney function damage.
Professional doctors will answer your questions.
The practice is reasonable. Aspirin is a commonly used drug to prevent cardiovascular and cerebrovascular diseases, and many users take it. It plays a role by inhibiting platelet aggregation function, avoiding plaque rupture caused by atherosclerosis, and preventing platelets from accumulating in large quantities to form thrombus, blocking blood vessels and causing infarct diseases, which requires long-term administration.
In the process of long-term use, the biggest adverse reaction of aspirin is gastric mucosal bleeding. Although the incidence is low, it needs to be avoided as much as possible. After taking aspirin, acetylsalicylic acid, the main component, will damage the gastric mucosa when it is decomposed in the stomach. We can avoid this situation by trying to keep aspirin from decomposing in the stomach.
Therefore, aspirin enteric-coated tablets were produced, that is, a layer of coating was added on the outside of ordinary aspirin, which can resist gastric acid and ensure that aspirin does not decompose in the stomach, and only when it directly enters the small intestine in an alkaline environment will it decompose. Technically speaking, aspirin can be called enteric-coated tablets as long as it does not decompose more than 90% in the stomach and is coated with anti-gastric acid. However, in order to improve the anti-decomposition rate, aspirin can enter the small intestine as soon as possible through the stomach, which plays a certain auxiliary role. Obviously, taking it on an empty stomach will be less disturbed by food and help to achieve this goal.
It can be seen that taking aspirin enteric-coated tablets on an empty stomach is more conducive to reducing the damage to the stomach, and it is generally better to take it before meals 15-30 minutes. As for eating in the morning or on an empty stomach at night, there are no strict and clear rules. You can take it according to your own habits. The key is to take it for a long time and keep enough drug concentration in the blood. If you take it intermittently, it will not play its due role in preventing thrombosis.
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Aspirin is a commonly used anti-platelet aggregation drug, and it is also a representative drug in anti-platelet aggregation drugs. Many patients with cardiovascular and cerebrovascular diseases have the impression that aspirin is the medicine they take. What does aspirin do? When should I eat? Which is better to eat nuclear on an empty stomach or after meals? Let's explore the truth together!
1. What is the function of aspirin?
The main function of aspirin is to prevent platelet aggregation, which can irreversibly combine with platelets, thus reducing acute events related to arterial blood vessels. Therefore, aspirin is one of the important drugs to prevent arterial diseases, such as common coronary heart disease and cerebral infarction.
2. Are there many forms of aspirin?
Aspirin does have many dosage forms, such as aspirin tablets, aspirin enteric-coated tablets, aspirin enteric-coated capsules, aspirin effervescent tablets and so on. Moreover, the dosage specifications of aspirin are different, including 25 mg, 50 mg, 100 mg and other dosage forms.
3. When do I need to take aspirin enteric-coated tablets?
When is the best time to take aspirin enteric-coated tablets? Aspirin enteric-coated tablets have a clear label on the instructions, and aspirin enteric-coated tablets are recommended to be used on an empty stomach. This is mainly because if aspirin is taken during or after meals, its casing will be digested in the stomach, and then aspirin enteric-coated tablets will be absorbed in the stomach, which will greatly increase the incidence of adverse reactions in the digestive tract of patients. Using aspirin enteric-coated tablets on an empty stomach can effectively reduce the absorption in the stomach, thus reducing the irritation of aspirin to the digestive tract.
4. Should other forms of aspirin be taken on an empty stomach?
For aspirin tablets, or aspirin effervescent tablets and other dosage forms, it is necessary to use them at the right time according to the digestion and absorption characteristics and instructions of the dosage forms in order to effectively reduce the irritation to the digestive tract.
The elderly may be familiar with aspirin, which is known as the "century-old medicine". Since its discovery, it has found various applications, from colds and fevers to the prevention and treatment of cardiovascular and cerebrovascular diseases. For middle-aged and elderly people, many of them are also taken for a long time, mainly for the prevention and treatment of cardiovascular and cerebrovascular diseases.
Some people say that taking enteric-coated aspirin on an empty stomach is less harmful to the stomach. Is it true?/You don't say. Need to take aspirin for a long time will also increase the risk of medication. If you eat it incorrectly, the side effects will be more obvious. Among them, the most common side effect of patients taking aspirin is gastrointestinal reaction, because oral aspirin has a direct stimulating effect on gastric mucosa, manifested as abdominal discomfort, stomach pain, nausea and vomiting. Taking it in large quantities may also lead to erosive gastritis, gastric ulcer and even gastric bleeding.
Is aspirin good to eat on an empty stomach or after meals? Because aspirin can directly stimulate the gastrointestinal tract, patients naturally think that aspirin should be taken after meals, which will reduce the irritation to gastric mucosa and relieve stomach discomfort. It stands to reason that there is nothing wrong with such an idea. However, patients often ignore the advantages of drug dosage forms.
As a century-old medicine, the dosage form of aspirin has been continuously improved. At present, there are three main dosage forms of aspirin on the market, ordinary tablets, effervescent tablets and enteric-coated tablets, and their specifications and indications are actually different.
Generally speaking, the specifications of ordinary tablets and effervescent tablets are relatively large, such as 300mg effervescent tablets. This kind of aspirin preparation is mainly used for short-term use, and the indications are fever, pain and rheumatism. And there is no need to take it for a long time. Because it is taken for a short time, the stimulation to the gastric mucosa is also short-lived and generally does not have serious consequences. However, this dosage form of aspirin still needs to be taken after meals to reduce gastrointestinal reactions.
For aspirin that needs to be taken for a long time, aspirin enteric-coated tablets are commonly used in the market, and the specifications are relatively small, such as 100mg, 80mg, 75mg, 50mg, 25mg, etc. This is also the specification and dosage form used by the elderly to prevent and treat cardiovascular and cerebrovascular diseases. The improvement of enteric-coated tablets is mainly due to the stimulating effect of aspirin on gastric mucosa. The advantage of enteric-coated tablets is that it can reduce the irritation to the stomach, thus preventing the side effects caused by long-term use.
Enteric-coated tablets are called enteric-coated tablets because there is an enteric coating on the outside. Generally, it will not decompose in the stomach and will not stimulate the gastric mucosa. They will disintegrate and be absorbed after entering the intestine, thus greatly reducing the direct stimulation to the gastric mucosa. Therefore, aspirin enteric-coated tablets must not be disassembled to prevent the enteric coating from being destroyed. Various preparations on the market are also designed to meet the dosage requirements of patients.
Aspirin is a very common drug. Clinical guidelines for patients with cerebral infarction and coronary heart disease recommend long-term use. Even many patients with hypertension and diabetes are taking aspirin to prevent atherosclerosis and reduce the incidence of coronary heart disease or cerebral infarction. With more people using it and the popularization of this medicine by popular science, many people now have a certain understanding of this medicine. This medicine is indeed a good medicine, but it also has some imperfections-it damages the gastric mucosa and increases the risk of bleeding.
Why does aspirin damage gastric mucosa? The action principle of aspirin is to exert anti-inflammatory, analgesic and anti-platelet aggregation effects by inhibiting Cox (cyclooxygenase). COX (cyclooxygenase) can be divided into two forms: COX- 1 and COX-2, and this kind of COX- 1 (COX- 1) can protect the gastrointestinal mucosa, so the inhibition of aspirin on COX- 1 will damage the gastrointestinal mucosa, thus increasing the occurrence of gastric mucosal erosion, gastric ulcer and even gastric bleeding.
How to reduce the harm of aspirin to gastric mucosa? In order to prevent aspirin from being melted by gastric acid in the stomach, we make aspirin into enteric-coated tablets, that is, the tablets are coated with a drug film, which is not easy to dissolve in acidic environment but easy to dissolve in alkaline environment. The intestinal environment is alkaline, so aspirin enteric-coated tablets can be dissolved and absorbed in the intestine, and the direct damage of aspirin to gastric mucosa can be reduced.
In order to ensure that the enteric-coated tablets can reach the intestine smoothly, we all suggest that it is best to take them on an empty stomach, when you get up in the morning or half an hour before breakfast. Enteric-coated tablets will not be absorbed in the stomach, so there is no need to worry that taking them on an empty stomach will damage the gastric mucosa. Instead, it is protecting the gastric mucosa!
Taking enteric-coated aspirin on an empty stomach is less harmful to the gastrointestinal tract. Compared with ordinary aspirin taken after meals, enteric aspirin is recommended to be taken on an empty stomach, because it has an acid-resistant and alkali-resistant shell, which does not decompose in the acidic environment of the stomach, but only in the alkaline environment of the intestine.
If we take enteric-coated aspirin after meals, on the one hand, it will increase the retention time of aspirin in the stomach; On the other hand, eating will increase the pH in the stomach. These factors will lead to the early decomposition of enteric-coated aspirin in the stomach and increase the stimulation to the gastric mucosa. Therefore, it is recommended to take enteric-coated aspirin on an empty stomach, whether before bed or in the morning.
Aspirin is a widely used drug in clinic, which is mainly used for the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases. It should be used under the guidance of a doctor, fully evaluate the condition, strictly control the indications and eliminate contraindications. At the same time, we should also pay attention to monitoring the changes of the disease and observe whether there are any side effects.
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The most prominent side effect of aspirin is the damage and irritation to the digestive tract, which may cause gastric mucosal bleeding. So many people are worried about taking aspirin. Should they take it every day? When to eat? Eat before or after meals, in the morning or before going to bed …
Generally speaking, when doctors in neurology remind patients to take aspirin every day to prevent cerebral infarction, or to prevent the recurrence of cerebral infarction, they will suggest taking it before going to bed or getting up in the morning, and also suggest buying imported aspirin, namely aspirin enteric-coated tablets.
The main purpose is to prevent aspirin from causing irritation and damage to gastric mucosa.
At present, there is some controversy about whether aspirin should be taken before bed or in the morning, but it is not enough to attract patients' attention. Both methods can be used.
Enteric aspirin can cross an empty stomach and reduce the irritation to gastric mucosa, which is established and recommended.
If you take aspirin to prevent recurrence of cerebral infarction, you must insist on reexamination every other year. In addition, we should pay attention to whether there are oral bleeding, tooth brushing bleeding, skin mucosal bleeding, occult blood and so on in our daily life.
From the role of aspirin, it can prevent platelet aggregation and reduce the incidence of cerebral infarction. This benefit outweighs its side effects, and the overall benefit outweighs its harm.
Therefore, if it is necessary for patients to take aspirin under the guidance of a doctor, they should insist on taking it, don't worry too much, pay attention to reexamination and observe abnormalities.