Can occupational mild DMF poisoning constitute a grade?

Mild poisoning can't be rated, but you can claim the body infection fee from the unit. Good luck and good health. After the toxicant is absorbed by various ways, it is mainly demethylated by mixed functional oxidase in liver microsomes, and a methyl group is removed. The metabolites are monomethyl formamide and formamide, which are metabolized quickly. Formamide stays in the blood for a little longer, then it is metabolized into formic acid and ammonia, and part of dimethylformamide is excreted from urine and breath in its original form. People inhale DMF 3.4h a concentration of 63 mg/m for 3.4 hours every day for * * * 5 days. After stopping contact for 4 hours, DMF in blood could not be detected, the inhalation concentration was 30 mg/m 3, and the excretion of metabolites accounted for 6 1 ~ 86% of the total within 24 hours. When the inhalation concentration is 60 mg/m 3, the excretion of monomethyl formamide in urine is less than 30 mg within 24 hours, and it cannot be detected within 48 hours; When the concentration is 27 mg/m 3, the amount of monomethyl formamide in urine is about 25mg within 24 hours after inhalation for 5 days, so it is suggested that the concentration of monomethyl formamide in urine exceeds 60mg within 24 hours, suggesting that the concentration of exposure to DMF has exceeded 60 mg/m 3, so it is considered that monomethyl formamide in urine can be used as a monitoring index of exposure to DMF.

Irritating to eyes, skin and respiratory tract.

After invading the body, it is mainly metabolized in the liver and quickly excreted. The main target organ is the liver, and the kidney is also damaged to a certain extent, and it is moderately poisoned.

clinical picture

Acute poisoning usually occurs 6 ~ 12 hours after respiratory inhalation; Skin invasion, the incubation period can be longer, and there are reports of poisoning after skin burns are basically healed. For subacute poisoning cases, the time from exposure to onset is 2 ~ 4 weeks.

Clinical features:

Irritation symptoms: DMF vapor has mild and moderate irritation to eyes and upper respiratory tract.

Skin: Contaminated skin can cause mild to severe burns, wrinkled skin, pale face and burning sensation. In severe cases, it can make the skin swell, and in severe cases, it can burn.

Eyes: polluted eyes cause burning pain, tears and conjunctival congestion; Severe cases can cause corneal necrosis.

Gastrointestinal symptoms: patients often have loss of appetite, nausea, vomiting, abdominal discomfort and constipation, and a few cases have upper-middle abdominal pain.

Liver: In acute poisoning, liver damage is often prominent. The patient has obvious fatigue, swelling and pain in the right upper abdomen, discomfort, jaundice, gradually enlarged liver and tenderness. The routine examination of liver function is abnormal, among which the serum transaminase is obviously increased. The lesions are generally not serious, and can be gradually relieved after treatment, and the condition can be fully recovered within a few weeks.

Severe acute poisoning: severe toxic liver disease, and occupational poisoning is rare. Contact with high concentrations, especially those with serious skin pollution, should be alert to serious poisoning.

Life poisoning: There was once a patient with chronic ulcerative colitis who used DMF enema as a therapeutic drug and caused liver disease. The condition gradually worsened, similar to subacute hepatic necrotizing hepatitis, and hepatic coma occurred within 2 weeks, with a dangerous prognosis.

Special risk: patients with liver diseases of various reasons are sensitive to DMF.