Jilin Changchun Changsheng Company's problem vaccine case is a serious illegal act of vaccine production enterprises to make huge profits, violate the national drug quality management standards, and fabricate false records to manufacture and sell problem vaccines. The case involves many responsibilities, including the dereliction of duty of the enterprise itself, the oversight of the regulatory authorities and the dereliction of duty of the local government. This kind of behavior endangers public health and safety, and exposes regulatory loopholes and institutional defects.