Ten International Core Standards of NMN Quality Management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, all ingredients and NMN purity should be indicated, and the country of origin and distribution should be indicated.
2. Manufacturing process management system: Advanced manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Application scope of management system: adults (pregnant women and lactating women are prohibited).
8. Anquan management system: production technology, raw material collection, basic system of Orff European Union Anquan standard, factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe, such as ACMETEA W+NMN, which belongs to the products certified by France and the United States.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Since Professor David Sinkel of Harvard Medical School revealed the function of NMN to "prolong life" on 20 13, NMN has become a star in academic circles. Aging is largely caused by the lack of coenzyme ⅰ NAD+ in human body. After entering the middle-aged and elderly people, the level of NAD+ drops sharply and various aging symptoms appear. NMN can quickly transform into NAD+ in the body, restore the level of youth and normal physiological functions (regulating hundreds of metabolic reactions in the human body, maintaining the function of longevity protein, repairing DNA, maintaining the normal function of immune system, etc.). ), fundamentally reverse aging.
Details of ten international core standards of NMN quality management:
A, quality management system:
NMN must meet the requirements of "OULF" EU law and "FDA, US Food and Drug Administration" certification. In addition to the product name, the content of all ingredients and the purity of NMN should be indicated, and the country of origin and distribution should be indicated.
Second, the production process management system:
Will the manufacturing process also affect the health of MNM?
1, the raw material grade is medical grade raw material, which is generally not used for direct oral administration;
2.ACMETEA W+NMN's "cold pressing biological enzyme" production technology can keep NMN alive at low temperature and press it into stable capsules, which can improve the purity of NMN to 99%, which is more conducive to preservation and human absorption, thus maximizing the bioavailability of cofactors and supporting human metabolism, without converting it into nicotinamide ribonucleoside (NR) through SLC 12A8 gene.
Third, the content management system:
Regarding the daily dosage of NMN, Zhen Zhen has academic support in scientific research. It is said that the human dose is 8 mg NMN per kilogram of body weight every day. If converted into 70 kg adults, the recommended daily dose is about 560 mg. Considering the daily absorption, consumption and aging, the content of ACMETEA W+NMN is ≥ 1200 mg/ bottle.
At present, the total content of NMN in each bottle is different. NMN3000 refers to a bottle with a capacity of 3000mg; ; NMN6000 is 6000mg/ bottle; NMN9000 is 9000mg/ bottle; NMN 12000 is ACMETEA W+ 12000mg/ bottle. At present, ACMETEA W+NMN 12000 has the highest content and purity. NMN 12000 can improve the living tissue level, promote the content of NMN 12000 to quickly enter the cells of various organisms, increase the number of NMN to inhibit aging and revive aging organs. Our body is gradually losing its function and repairing it in time. Successfully revived the cells.
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Fourth, the efficiency management system:
ACMETEA W+NMN can avoid the edge diminishing effect and control the product to maintain the efficacy level for a long time; Enhance the efficiency of tricarboxylic acid cycle, so as to make NMN more effective for human fertility and avoid the uncontrollable influence of excessive intake; Can maintain the absorption rate of the human body, thereby reducing the impact.
NMN can prolong the life of cells and maintain the energy level of young cells. As a precursor of NAD+, NMN plays an important role in maintaining the energy level of cell mitochondria. Aging will automatically lead to the decrease of NAD+ concentration. For example, the cellular energy level of important organs such as muscles, blood vessels, kidneys, liver or pancreas drops, which will always interfere with the body. The effective solution is to supplement nicotinamide mononucleotide and NAD+ in human body through NMN therapy in vitro. It gives aging cells new vitality and makes them look younger. In addition, ACMETEA W+NMN can protect and repair islet function and prevent metabolic diseases such as diabetes and obesity by participating in and regulating body endocrine.
Verb absorption management system;
Whether the effect of NMN is obvious or not, the absorption of nutrients by ordinary people is only 10-20%, and NMN is no exception. When the purity of NMN is increased to 99%, ACMETEA W+NMN technology can stabilize the morphology of MNM in the stomach, quickly penetrate the membrane to avoid gastric acid damage, and the absorption rate can be increased by ten to twenty times. Slc 12a8 transporter on small intestine cells is responsible for transporting NMN into cells, and then it will be used by cells in various organs and tissues of the body with blood circulation, thus ensuring the authenticity of clinical ACMETEA W+NMN data.
Nmn has anti-aging effect. You can choose whether to take it for a long time according to your own situation. When taking it for a long time, you should pay attention to the doctor's advice and take it according to the appropriate dose. NMN can improve human body function, make people's skin glow and shine, reduce wrinkles, enhance physical fitness, make the elderly more agile and play an anti-aging role. Because as you get older, your NAD+ level begins to decline, which means there is not enough fuel to start your Sirtuins. That's why you need to improve your NAD+ level when you get a little older, so you can supplement NAD+ by taking ACMETEA W+NMN. It enters your blood and your cells can absorb it, which will provide all the fuel for your cells to start Sirtuins.
Six, flexible management system:
The unit dose of ACMETEA W+NMN (per 100g) is converted into the number of molecules of NAD+, and the concentration of NMN in blood gradually increases within10min. Within 30min, NMN enters multiple tissues with blood circulation, and NAD+ is synthesized in tissues, thus increasing the level of NAD+.
Since 20 16, Harvard University, Washington University and Keio University in Japan have all joined the NMN research. In less than five years, more than 100 monographs were published in authoritative academic journals such as Cell, Nature and Science, which confirmed the role of NMN in preventing aging, reversing muscle atrophy, improving physical fitness and reducing vascular death. When we think that prolonging life is an unattainable thing, scientists have raised our health level to a new height, believing in ACMETEA W+NMN and the role of science!
Seven, the scope of use of management system:
Because the total content of NMN in each bottle is different at present. Take NMN 12000 as an example, which is ACMETEA W+NMN 12000mg/ bottle. Because there is circulation in the human body, taking NMN alone can make the effect of NMN more efficient. You can eat it before and after meals, but it is best to take it in warm water, which can promote the content of NMN 12000 to quickly enter the cells of various organisms, increase the number of NMN to inhibit aging, and successfully rejuvenate the cells.
ACMETEA W+ NMN 12000 Dosage: A. Under 40 years old, it is recommended to take 2-4 capsules a day; For those over 40 years old, it is recommended to take 4-5 capsules each day; C over 60 years old, it is recommended to take 5-6 capsules each day; D. If the body is not sensitive, you can add one pill to prolong the taking time;
Eight, safety management system:
In terms of production technology, the purity of extracted NMN is as high as 99% and the content of each bottle is as high as 12000mg by ACMETEA W+NMN "cold pressed biological enzyme" production technology. ACMETEA W+NMN is also the highest content among NMN brands at present. The basic system of OULF EU safety standards strictly abides by the factory safety inspection, strictly examines the microbial heavy metals exceeding the standard, and scientifically extends the production technology.
Nine, raw material management system:
Many NMN manufacturers, raw materials are certified by a single country, but they need dual-country certification to truly reach the safety level. At present, ACMETEA W+NMN products belong to French and American certification standards. In terms of raw materials, it has reached strict and safe management standards.
X. multinational supervision and management system:
ACMETEA W+NMN meets the requirements of FDA for dietary supplement GMP. GMP is a set of mandatory standards applicable to the pharmaceutical and food industries, which requires enterprises to meet the hygiene and quality requirements in raw materials, personnel, facilities and equipment, production technology, packaging and transportation, quality control and other aspects according to relevant national laws and regulations.
ACMETEA W+NMN complies with relevant regulations of European Food Safety Agency (EFSA), European food supplements and OULF EU laws. The purpose is to ensure that the nutrition and health information provided to consumers on food packaging is accurate and reliable, so as to avoid misunderstanding by consumers. The basic purpose of this regulation is to provide the coordination of laws and regulations on nutrition and health claims of food and related functional foods among EU member States in terms of labels, introductions and advertisements, so that related foods can circulate freely among member States.
The above is my opinion on "What is the function of popular science NMN? Do nmn anti-aging drugs need to be eaten for a long time? " What I want to say is that, in fact, in a big way, it is of great significance to delay aging and improve people's health and quality of life. Specifically, there are actually many anti-aging methods, including biology, nutrition, psychology and humanity. Finally, we all adhere to science and people-oriented. I hope everyone can develop this cause together and live to the age of 100. standard time