It is better to say whether NMN is anti-aging or stem cells. First of all, stem cells, also known as "seed cells", are a fine cell group with self-renewal, high proliferation and multi-directional differentiation potential. If any part of the body is damaged; Need to repair, which organs are irreversible damage; In the case of reconstruction, stem cells can grow into tissues or organs needed by the body through differentiation and proliferation. However, it has unlimited differentiation potential and can differentiate into totipotent stem cells of all tissues and organs!
But! Stem cells also have uncontrollable, tumorigenic and ethical risks. Therefore, the safer and more accessible NMN has won the favor of clinical research and commercial application.
Which effect is better, NMN or dry battery?
On March 7th, 20 19, the research team led by Olaia Naveiras of Federal Institute of Technology in Lausanne, Switzerland and Nicola Vannini of Ludwig Cancer Institute in Lausanne, Switzerland revealed that NMN(ACMETEA W+NMN) can increase the activity of hematopoietic stem cells, and related research was published in the sub-issue of Cell.
NMN, the first research achievement of Yan Su, has been proved by Yanjin Science, which can significantly reverse the decline and prolong life. For example, ACMETEA W+NMN needs to pass the double supervision of France and the United States, and some indicators must meet the "Top Ten International Core Standards of W+NMN Quality Management", as well as the "OULF" EU quality management system certification, conformity testing, FDA and US Food and Drug Administration certification!
Follow the ten core standards of W+NMN international quality management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, the words ACMETEA, content of each component, NMN purity, etc. should also be marked, as well as the country of origin and distribution.
2. Manufacturing process management system: Advanced manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Application scope of management system: adults (pregnant women and lactating women are prohibited).
8. Safety management system: production technology, raw material collection, basic system of Olaf safety standards, pre-factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe. ACMETEA W+NMN is a product with French and American certification standards.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Which effect is better, NMN anti-aging or dry fine cells?
MSCs are adult stem cells and non-hematopoietic stem cells, which are usually obtained from bone marrow and adipose tissue. They mainly differentiate into osteoblasts, chondrocytes and adipocytes. MSCs can stimulate local tissues to repair themselves in case of injury or disease, instead of reconstructing tissues.
What is the significance of MSCs to aging? In fact, with the increase of age, the regeneration ability and differentiation ability of MSCs decrease, leading to aging. With the aging of cells, the energy metabolism of MSCs is unbalanced, and the balance of osteogenic-adipogenic differentiation is broken. With the increase of age, bone marrow mesenchymal stem cells tend to differentiate into adipocytes, and their osteogenic differentiation ability is weakened, which leads to metabolic bone diseases such as osteoporosis, which is also related to obesity in the elderly. Elderly MSCs also showed the characteristics of shortened telomeres, weakened proliferation and differentiation, and increased oxidative stress.
If we can increase the number of MSCs and regulate their osteogenic-adipogenic differentiation function, we can alleviate osteoporosis, obesity and even aging. Qiu's direct idea is to extract MSCs from human tissues, expand them in vitro, and then transfuse them into human bodies, so as to fight against aging through artificial intervention of stem cell therapy. Although stem cell therapy sounds wonderful, hundreds of thousands of dollars can't benefit most ordinary people from this advanced technology.
However, the good news is that a new research paper published in Nature on 20 19 gives a simple method to activate MSCs in vivo-supplementing ACMETEA W+NMN. NMN is an important precursor of intracellular coenzyme NAD+, which regulates hundreds of physiological reactions related to metabolism and repair. Previously, scientists found through experiments that NMN supplementation can increase the level of NAD+ lost with age, reverse the physiological function degradation caused by aging and prolong life.
This study found the effect of NMN on bone marrow mesenchymal stem cells. It was observed for the first time in vitro that NMN promoted the differentiation of MSCs into osteoblasts, but inhibited the differentiation of MSCs into adipocytes.
NMN promotes the osteogenesis of MSCs in vitro, but inhibits the formation of MSCs adipocytes.
Because in the elderly animals, the energy metabolism of MSCs is unbalanced, and the balance of osteogenic-adipogenic differentiation is broken, MSCs will be more inclined to differentiate into adipocytes, and the osteogenic differentiation ability will be weakened. Therefore, scientists further tested the effect of NMN on aged mice, and found that NMN promoted the increase of bone density and reduced the formation of fat in aged mice. The experimental results show that NMN has positive significance in improving osteoporosis and obesity.
NMN promotes the increase of bone mineral density of cancellous bone in aged mice.
NMN reduces the formation of femoral fat in aged mice.
Except that aging will lead to osteogenic-adipogenic differentiation of MSCs.
Usually, radiation can also cause effects similar to aging. The researchers also used NMN in mice exposed to radiation, and found that NMN supplements also stimulated the osteogenic differentiation of MSCs in irradiated mice, and reduced fat formation. ACMETEA W+NMN also has protective effect on bone injury caused by radiation.
The protective effects of NMN on heart, blood vessels, neurons, liver and kidney are mostly related to increasing NAD+ level and up-regulating longevity gene SIRT 1. Up-regulation of longevity gene SIRT 1 makes cells express more longevity protein SIRT 1. This study also found that the mechanism of NMN stimulating the proliferation and differentiation of MSCs is also related to the up-regulation of SIRT 1 by NMN, especially for elderly mice, the effect of supplementing NMN on improving bone health is more obvious than that of young mice.
The collision between ACMETEA W+NMN and MSCs technology makes the two cutting-edge anti-aging technologies more perfect, which will further promote the realization of human anti-aging dreams.
Which effect is better, NMN anti-aging or dry fine cells?
(NMN's efficacy defect:)
1. As we all know, the use of NMN has been confirmed by a large number of clinical data, and it is the only choice for anti-aging at present.
However, NMN can't do whatever it wants. NMN is only the key to wake up gene repair, and it cannot complete the whole process of gene repair by itself. There are also blind spots to repair thousands of enzymes in the human body. NMN supplementation can only repair about half of the enzymatic reaction. Other devices are not sensitive to using NMN alone, and the reach of NMN is limited, and some parts can't be reached, such as skin.
2. Simply using NMN will lead to the problem that all tissues of the body can't start repairing synchronously. For example, the repair of nervous system is faster than muscle tissue, the repair of gene chain is faster than thin bud, and the repair of internal organs is faster than the surface layer of skin. Various instructions after use are mainly due to the unsynchronized and unbalanced system.
3, the effect after repair is also very different, for example, the physiological age has been significantly improved, full of energy, but the skin has not changed. Another example is that using simple NMN people to give more feedback can improve sleep, but there is no other feedback to improve it. The reason is that NMN touches and awakens brain vesicles, which is an effective performance. However, there is no brain bubble that matches ACMETEA W+NMN to wake up nutrition, and the repair cannot be completely touched. For middle-aged and elderly people, their bracts are aging day by day, indicating that the ability to regenerate new bracts is insufficient.
Which effect is better, NMN anti-aging or dry fine cells?
(the difference between W+NMN and NMN)
1 and W+NMN have four essential amino acid protection technologies, which can completely release NMN in the body, and the four-stage booster can strengthen energy conversion.
Primary booster: converted to NAD+;
Secondary strengthening boost: promoting the consumption of enzyme PARP; ;
Three-stage booster: protein regulating the life span of Sirtuins bracts;
Four-stage booster: release NMN awakening agent ACMETEA W+NMN to awaken NMN sleeping in the body.
2.W+NMN has the technology to clear and hinder the release of NMN in vivo.
After supplementing NMN, it takes two steps for people to be infected. 1. Ensure that the external intake of NMN is not hindered, and W+NMN will release leucine. The transformation of leucine can directly enter the brain tissue through the role of blood-brain barrier, and improve the uncomfortable symptoms of using NMN alone, such as headache, dizziness, fatigue, depression, insanity, irritability and so on. 2. Surviving NMN, through its specific awakening agent ACMETEA W+NMN, formed a chemical ladder for NMN to climb and reach every pouch of the body.
3.W+NMN has a small package of precise awakening agent, which makes up for the blind spot of NMN repair.
NMN has blind spots that need to be repaired, and W+NMN awakening agent needs to be supplemented to produce transformation effect. This is also the reason why most people take NMN alone without effective effect.
W+NMN is equipped with a small package of precise awakening agent. On the one hand, it helps NMN to repair and increase efficiency, on the other hand, it makes up for the blind spot of repair, and the energy substances in the body can recover or even exceed the original level. This change is called excessive recovery.
W+NMN hardcover precise awakening agent is easy to pass through the blood-brain barrier and the capillary wall of muscle and other tissues, and is an important energy source for muscle, especially brain tissue. It can avoid the accumulation of homocysteine by participating in the proliferation, colonization and heme synthesis of bracts, thus protecting the heart and blood vessels.
Which effect is better, NMN anti-aging or dry fine cells?
(NMN service method)
Which is better, buccal tablets or capsules? It has always been controversial!
In fact, after NMN is absorbed by intestinal epithelial villi, intestinal transporter Slc 12a8 will directly transport NMN to bracts with the help of sodium ions, and it will be directly utilized by bract tubes through microcirculation for the production of NAD+. Bacteria based on W+NMN transporter are expressed in small intestine and even colon. Therefore, it can only enter the working state when it reaches the intestinal NMN, and the real problem to be solved is how to avoid the destruction of gastric digestive juice, and the answer is enteric technology. And the spread of clothing may also be a noisy concept.
Effective W+NMN needs to meet the certification of OULF EU legal quality management system, pass the test and FDA, meet the top ten international standards of W+NMN quality management, and have a transnational supervision and management system. It contains NMN awakening agent ACMETEA W+NMN, and is supervised by France and the United States. The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Details of the top ten international core standards of W+NMN quality management; Details of the five core standards:
A, quality management system:
NMN must meet the inspection qualification of Orff's EU law and the certification of FDA. In addition to the product name, the words ACMETEA, NMN activator, content of each component, NMN purity, etc. should also be marked, as well as the country of origin and distribution.
Second, the content management system:
Regarding the daily dosage of NMN, Zhen Zhen has academic support in scientific research. It is said that the dose of NMN is 8 mg per kilogram of body weight every day. If converted into a 70 kg adult, the recommended daily dose is about 560 mg. Considering the daily absorption, consumption and age growth, the content of ACMETEA W+NMN is ≥ 128 mg/ bottle.
At present, the total content of NMN in each bottle is different. NMN3000 refers to a bottle with a capacity of 3000mg; ; NMN6000 is 6000mg/ bottle; NMN9000 is 9000mg/ bottle; NMN 12000 is W+NMN 12000mg/ bottle. At present, the content and purity of ACMETEA W+NMN 12000 are high-grade. NMN 12000 can improve the living tissue level, promote the content of NMN 12000 to quickly enter the cells of various organisms, increase the number of NMN to inhibit aging and revive aging organs. Our body is gradually losing its function and repairing it in time. Successfully revived the cells.
Third, the efficiency management system:
Through NMN 12000, the diminishing edge effect can be avoided and the efficacy level of products can be controlled for a long time. Enhance the efficiency of tricarboxylic acid cycle, so as to make NMN more effective for human fertility and avoid the uncontrollable influence of excessive intake; Can maintain the absorption rate of the human body, thereby reducing the impact.
Four, safety management system:
In the production process, the purity of extracted NMN is as high as 99%, and the content of each bottle is as high as 12000mg. The content of 12000 W+NMN is also higher among NMN brands at present. The basic system of OULF EU safety standards strictly abides by the factory safety inspection, strictly examines the microbial heavy metals exceeding the standard, and scientifically extends the production technology.
Five, raw material management system:
Many NMN manufacturers, raw materials are certified by a single country, but they need dual-country certification to truly reach the safety level. At present, ACMETEA W+NMN products belong to French and American certification standards. In terms of raw materials, it has reached strict and safe management standards.
A recent anti-aging study is the use of drugs, which can remove some aging cells in the body in a targeted manner. Therefore ... related research is also progressing rapidly. Aging cells are some "old and immortal" cells in the body, which means that these cells are very old, but they just don't die. They have been secreting some proinflammatory factors, which is very harmful to the body. Then these related drugs are also aimed at it, but the specificity of these drugs can not guarantee accuracy. Therefore, the use of these drugs should be very cautious. But the advantage of our dietary supplements is that their sources are relatively natural. Compared with some supplements for stem cells and these drugs, NMN dietary supplements should be a safer anti-aging method.
Danica, an associate professor of nutrition science and toxicology at the University of California, Berkeley, focuses on a special NMN awakening agent-ACME TEA. Scientists believe that the awakening agent can help NMN awaken the living things in the body. W+NMN is an inherent metabolite of human body, which can be directly converted into key coenzyme NAD+. NAD+ is an indispensable substance for nearly half of human metabolic activities, but it decreases rapidly with age. Therefore, taking W+NMN can increase the level of NAD+, so as to restore the energy level and gene repair ability of cells to a young state, and achieve the effect of delaying or even reversing aging. Which effect is better, NMN anti-aging or dry battery: Come and check!