Unlike taking short-acting antihypertensive drugs several times a day, patients tend to forget to take them or miss them, and their blood pressure fluctuates easily, so patients can't persist in the end, and eventually there will be serious complications such as hypertensive nephropathy and hypertensive cerebral hemorrhage, and the future troubles will be endless.
What antihypertensive drugs have long antihypertensive time and good effect?
1. Calcium channel blockers: Long-acting antihypertensive drugs include amlodipine besylate, levoamlodipine and felodipine sustained-release tablets. These drugs have a long half-life. Generally, after 7 10 days of continuous administration, the concentration of antihypertensive drugs in blood reaches a stable state, which can exert the greatest antihypertensive effect.
2. Beta blockers: The representative drugs are carvedilol and bisoprolol, both of which are long-acting antihypertensive drugs. As long as it is taken once a day, the drug effect can last for 24 hours.
3. Angiotensin Converting Enzyme Inhibitor (ACEI) and Angiotensin Ⅱ Receptor Blocker (ARB): The representative drugs are Benazepril, Fosinopril, Perindopril and Valsartan, and their antihypertensive effects can last for 24 hours.
4, diuretic antihypertensive drugs: such as indapamide (Shoubishan)
Under normal circumstances, although these antihypertensive drugs have antihypertensive effect a few days before taking them, the antihypertensive effect is generally not immediate, mainly because it takes about 65,438+0 weeks for these antihypertensive drugs to achieve a stable antihypertensive effect, which we often encounter. The antihypertensive effect was not obvious a few days before starting taking medicine. Some people also suspect that the reason for the measurement is that patients are not sensitive to this antihypertensive drug, and they all consider changing the antihypertensive scheme. But after a day or two of patient observation, blood pressure has dropped. What I want to say here is, if this happens, don't change the antihypertensive plan prematurely. If you wait, things will often work out.
Of course, nothing is absolute. If there is a life-threatening hypertension crisis, it is not appropriate to choose long-acting antihypertensive drugs. At this time, it is necessary to choose short-acting antihypertensive drugs, and even some patients need to use intravenous antihypertensive drugs to lower their blood pressure to a safe level in a short time. When patients' blood pressure is stable, they will transition to using long-acting antihypertensive drugs to control their blood pressure.
Hypertension will bring complications such as atherosclerosis, cardiovascular and cerebrovascular diseases, and kidney diseases. Controlling blood pressure at a normal level can reduce the occurrence of these complications.
Lowering blood pressure requires continuity and stability to bring greater benefits. Therefore, antihypertensive drugs generally recommend long-acting antihypertensive drugs, and the antihypertensive effect is more stable.
Generally speaking, antihypertensive drugs that can stably lower blood pressure once a day can be regarded as long-acting antihypertensive drugs. There are mainly two kinds: one is drug half-life, which takes a long time to play a role in the body; On the other hand, although the drug itself has not been metabolized for a long time, it has achieved the effect of the drug for a longer time through slow release or controlled release technology. The names of these antihypertensive drugs often bear the words of slow release or controlled release.
Let's talk about several commonly used antihypertensive drugs in detail. What are the long-acting antihypertensive drugs commonly used in clinic?
1. angiotensin Ⅱ receptor antagonist, commonly known as sartan.
This kind of drug half-life is a long-acting antihypertensive drug, which can only be taken once a day.
Commonly used are: valsartan, the terminal half-life is 9 hours, and the efficacy can last for 24 hours;
Telmisartan with a terminal half-life of 20 hours inhibits angiotensin II for 24-48 hours;
In addition, losartan is commonly used, and the terminal half-life is 6-9 hours; The terminal half-lives of candesartan and irbesartan are 9- 13 hours and 1 1- 15 hours respectively. They are also antihypertensive drugs taken once a day.
The second is angiotensin converting enzyme inhibitor, commonly known as Puli.
Similar to sartan, antihypertensive drugs are mostly long-acting antihypertensive drugs. Perindopril, Ramipril, Fosinopril and Benazepril are commonly used. The half-life of fosinopril is 1 1.5- 14 hours; The efficacy of perindopril is also 24 hours, and the terminal half-life of benazepril is 22 hours. These are long-acting antihypertensive drugs and can be taken once a day. However, it should be noted that the first generation of benazepril is a short-acting antihypertensive drug, and the second generation of benazepril is a medium-acting antihypertensive drug.
Third, calcium antagonists, commonly known as the horizon.
The terminal half-life of amlodipine besylate is 30-50 hours, which is a "real" long-acting antihypertensive drug.
In addition, although some calcium antagonists have a short half-life, they are made into sustained-release tablets or controlled-release tablets, which are also used as long-acting antihypertensive drugs. Including nifedipine controlled-release tablets/sustained-release tablets; Felodipine sustained-release tablets, nicardipine hydrochloride sustained-release capsules, etc. Due to the slow or controlled release of these drug release systems, long-term and stable antihypertensive effects have also been realized in practical medication.
Fourth, beta blockers, commonly known as lol.
Most of these drugs are short-acting drugs, but some of them are made into sustained-release preparations, such as metoprolol tartrate sustained-release tablets;
Bisoprolol is a long-acting antihypertensive drug, its plasma half-life is 10- 12 hours, and it can maintain the antihypertensive effect in plasma for 24 hours.
Five, some compound antihypertensive.
Such as sartans, granules, diuretics or horizon. It is also a long-acting antihypertensive drug.
Everyone can choose their own antihypertensive drugs according to their blood pressure level and whether they have other chronic diseases. The purpose of blood pressure reduction is to reach the standard first, and stability is very important.
Blood pressure is not the lower the better, the sooner the better, but the blood pressure should be gradually controlled to the target value, the blood pressure should be stable, and the blood pressure should not fluctuate too much in one day. Therefore, long-acting antihypertensive drugs are the best choice.
What is a long-acting antihypertensive drug:
Long-acting antihypertensive drugs only need to be taken once a day. Advantages: ① Blood pressure is controlled stably for 24 hours, and the damage to blood vessels is light; ② Taking medicine is convenient and not easy to forget.
There are five commonly used antihypertensive drugs, including long-acting preparations:
(1) calcium channel antagonist, called "XXX".
There are nifedipine controlled release tablets, felodipine, amlodipine and so on.
② Angiotensin converting enzyme inhibitor, called "XXX".
Enalapril, benazepril, ramipril, lisinopril, perindopril, fosinopril, trandolapril, midazolam, etc.
Note: Captopril is not a long-acting preparation and needs to be taken 2-3 times a day.
③ Angiotensin inhibitor, called "so-and-so sartan"
All sartans are long-acting preparations, including losartan, valsartan, irbesartan, candesartan, telmisartan, irbesartan, olmesartan, alisartan, Ipsa and so on.
(4) Diuretics:
Belonging to long-acting hydrochlorothiazide, indapamide and amiloride.
(5) Beta blockers
Metoprolol sustained-release tablets and bisoprolol belong to the long-acting category.
Dr Duan specially reminded:
(1) Short-acting antihypertensive drugs can also be taken, but it needs to be taken 2-3 times a day, which is troublesome and blood pressure fluctuates greatly.
(2) antihypertensive drugs must be taken for a long time.
(3) If a antihypertensive drug can't control the normal blood pressure, it is best to take it in combination with other kinds of antihypertensive drugs in small doses. It is generally not recommended to take a single drug in large doses.
(4) Please check whether your antihypertensive drugs are long-acting preparations and whether you take them according to the prescribed times.
At present, most patients with hypertension are elderly people, and short-acting drugs are used twice a day, which is easy to forget. Therefore, long-acting drugs are the first of the four types of antihypertensive drugs recommended by the Guidelines for the Prevention and Treatment of Hypertension at the Primary Level.
In addition to long-acting preparations, compound preparations are also recommended in clinic. One tablet a day is very convenient, and these drugs are also very popular with patients, such as losartan and amlodipine tablets.
Long-acting antihypertensive drugs are characterized by slow onset time but long action time. Hypertension is a chronic disease. For patients, it is necessary to take medicine to control blood pressure to reach the target standard, so long-acting preparations are often used.
Reasons for recommending the use of long-acting drugs At present, there are many long-acting drugs recommended in the Guide to the Prevention and Treatment of Essential Hypertension, and you need to choose drugs according to your actual situation.
In addition to medication, patients with hypertension also need to adhere to a healthy lifestyle intervention. Only in this way can the blood pressure of drug control reach the standard be stable for a long time.
I am your friend Mix, who loves health. This article is written by hand, and everyone is welcome to criticize and correct me.
At present, other drugs used in clinic are generally twice a day or three times a day, because they need to be adjusted according to the actual situation. In the state of suffering from other diseases, only by controlling blood pressure relatively stably can the problems of other diseases be better solved. Therefore, you must take some antihypertensive drugs with strong publicity during hospitalization, but you need to switch to long-term antihypertensive drugs after you go home.
Now with the continuous progress of technology, generally speaking, there are the following types of long-acting antihypertensive drugs with good effects commonly used in clinic.
1 is the most commonly used nifedipine controlled release tablets. Everyone must distinguish it from nifedipine tablets and nifedipine sustained-release tablets, and it must be noted that it is a controlled-release tablet.
In this way, you only need to eat it once a day, and the effect is better.
However, the dosage of the drug must be adjusted according to the actual situation, and it needs to be increased if the blood pressure control is unstable.
The second most commonly used is valsartan or irbesartan, which takes effect relatively slowly and lasts only one tablet a day.
But it also needs to be adjusted according to the actual blood pressure.
Generally speaking, the adjustment of blood pressure is a long process. It can't be adjusted in a day or two, and there are various precautions. Blood pressure will fluctuate according to different conditions.
I wish you all good health!
We often say that it is best for patients with hypertension to choose long-acting antihypertensive drugs, which is also due to the consideration of medication compliance. On the one hand, long-acting antihypertensive drugs only need to be taken once a day, which can greatly reduce the chance of taking antihypertensive drugs by mistake. On the other hand, long-acting antihypertensive drugs often have a lasting effect and control blood pressure more smoothly. Therefore, optimizing long-acting drugs is an important medication principle to improve the long-term medication compliance of hypertensive patients and maintain blood pressure stability.
This paper introduces some long-acting oral pharmaceutical preparations of commonly used antihypertensive drugs.
1.CCB is the most common drug. Amlodipine is the most common antihypertensive drug in this class, and its drug half-life lasts for 35~50 hours. Ordinary tablets can effectively and stably control the pressure within 24 hours. Besides amlodipine, lacidipine and lercanidipine are also long-acting antihypertensive drugs. In addition, some drugs are short-acting drugs, and because of special pharmaceutical preparations, they can also play a long-term role in lowering blood pressure, such as nifedipine controlled-release tablets and felodipine sustained-release tablets. Diping drugs are widely used in clinic, such as the treatment of essential hypertension, the control of salt-sensitive hypertension, and the control of hypertension in the elderly. They are antihypertensive drugs with good antihypertensive effect and anti-atherosclerosis effect.
2.ACEI's drugs all have the word "Puli" in their names. Apart from the oldest captopril, other drugs such as enalapril, benazepril, ramipril, lisinopril and fosinopril are long-acting antihypertensive drugs. Powdered drugs can not only lower blood pressure, but also protect the heart and kidneys. They are widely used as antihypertensive drugs for diabetes complicated with hypertension, diabetic nephropathy complicated with hypertension and heart failure complicated with hypertension.
3.ARB drugs all have the names of sartan, losartan potassium, valsartan, olmesartan medoxomil, candesartan medoxomil and telmisartan. All of them are long-acting antihypertensive drugs, and their mechanism of action is similar to that of Pulitzer drugs, so their clinical application is similar. However, the sartans usually have no adverse reaction of dry cough that Pulitzer drugs may cause, so they can be used as substitutes for Pulitzer drugs.
4. Beta blockers can not only lower blood pressure, but also effectively control heart rate, relieve angina pectoris and protect the heart. Common long-acting drugs are metoprolol sustained-release tablets (betaloc), bisoprolol, nebivolol and so on. These drugs are long-acting drugs and can be taken 1 time every day. These drugs are commonly used antihypertensive drugs for patients with hypertension complicated with heart failure, hypertension complicated with myocardial infarction, hypertension complicated with tachycardia and atrial fibrillation.
5. Diuretics. Diuretics is an ancient antihypertensive drug and a very commonly used antihypertensive drug. It is usually used in combination with other antihypertensive drugs for synergistic hypotension. Among these drugs, hydrochlorothiazide, indapamide, spironolactone and so on. They are all long-acting diuretics and can be taken once a day. Diuretics are also widely used in the treatment of senile hypertension, refractory hypertension, newly treated hypertension and salt-sensitive hypertension.
6. Long-acting compound preparation, hypertension often needs combined medication control. At present, there are many fixed and long-acting compound pharmaceutical preparations for controlling hypertension on the market, so taking medicine once a day is equivalent to taking medicine twice to control blood pressure, which is also a good choice for hypertensive patients who need combined medication. From the traditional older compound reserpine tablets and Beijing Jiangya No.0 to newer compound preparations, such as losartan hydrochlorothiazide, telmisartan hydrochlorothiazide, valsartan amlodipine, lisinopril hydrochlorothiazide, amlodipine benazepril and other drugs, all belong to long-term antihypertensive drugs, and patients with hypertension can choose to use them according to the actual situation.
The latest China Cardiovascular Report 20 18 points out that there are currently 245 million hypertensive patients in China. For hypertension, we have always advocated the choice of long-acting and stable antihypertensive drugs, because long-acting antihypertensive drugs are not only convenient to take once a day, but also mainly to control blood pressure more stably and reduce and avoid the harm caused by large fluctuations in blood pressure.
At present, most hospitals and markets are long-acting antihypertensive drugs. Let's first remember several common short-acting antihypertensive drugs: nifedipine tablets, nifedipine sustained-release tablets I, nifedipine sustained-release tablets II, nicardipine, nitrendipine, captopril and metoprolol tartrate, which are relatively common short-acting antihypertensive drugs at present. There is also that we can read the instructions, once a day is long-term, and two or three times a day is short-term. We suggest taking antihypertensive drugs once a day.
Specific medication, it is difficult for us to answer the same question. Let's take a look at the special drugs for different age groups:
Children should use antihypertensive drugs with caution. Children younger than 18 should use antihypertensive drugs:
1. Pridine is one of the most commonly used antihypertensive drugs for children, and the only approved drug for children is captopril.
2. Diuretics. Drugs approved for children include triamcinolone acetonide, chlorothiazide, hydrochlorothiazide and furosemide.
3. Amlodipine is a drug approved for children.
4. Propranolol, atenolol and prazosin are approved for use in children.
5. At present, the use of sartans in children has not been approved.
Old people should also pay attention to medication. People over 65:
Diuretics, sartan, paracetamol and diazepam can all be the first choice, but many people will have many diseases in clinic, so other diseases should be considered before deciding what antihypertensive drugs to use. Generally, there are no special circumstances, and Lor antihypertensive drugs are not the first choice.
Five antihypertensive drugs are commonly used long-acting antihypertensive drugs:
Diping: nifedipine controlled-release tablets, nifedipine sustained-release tablets III, amlodipine besylate, levoamlodipine besylate, amlodipine maleate, felodipine, lercanidipine, lacidipine and benidipine are all long-acting antihypertensive drugs once a day. Diping antihypertensive drugs are suitable for simple high systolic blood pressure and salt-sensitive hypertension, and the common side effects are swollen feet, palpitation, blushing and tooth swelling.
Puli: Benazepril, Enalapril, Perindopril, Fosinopril, lisinopril, etc. It is also a long-acting antihypertensive drug, which can be taken once a day. Suitable for patients with cardiac insufficiency and heart failure, as well as patients with diabetes and nephropathy, with common side effects of dry cough.
Sartans: The antihypertensive drugs of sartans are all long-acting antihypertensive drugs, such as losartan potassium, valsartan, olmesartan medoxomil, candesartan medoxomil, telmisartan, irbesartan, etc. It is usually used when pril has side effects.
Lores: Metoprolol succinate and bisoprolol fumarate can not only lower blood pressure, but also control heart rate, relieve angina pectoris, treat heart failure and prevent arrhythmia. Common side effects include bradycardia, exacerbation of asthma and male erectile dysfunction.
Diuretics: hydrochlorothiazide, indapamide, spironolactone, etc. They are all long-acting diuretics and can be taken once a day. Diuretics are also widely used in the treatment of senile hypertension, refractory hypertension, newly treated hypertension and salt-sensitive hypertension. Although it is a long-acting antihypertensive drug, it is generally not used alone. In recent years, the combination of diuretics has achieved good results. The side effect is electrolyte disorder.
Of course, the general principle of choosing antihypertensive drugs in clinic is long-term stability, but for everyone, drugs must be selected according to blood pressure, age, sex, diabetes, angina pectoris, kidney disease, heart failure, myocardial infarction and so on.
If you have any cardiovascular, hypertension and hyperlipidemia problems, you can trust me privately and I will reply to you as soon as possible.
In order to reduce the incidence of cardiovascular and cerebrovascular diseases, many hypertensive patients need to take antihypertensive drugs for a long time to control their blood pressure. One of the principles of choosing antihypertensive drugs is to choose long-acting preparations. On the one hand, it can avoid missing medication, and the patient's compliance is better. On the other hand, it can avoid excessive blood pressure fluctuation and control blood pressure more smoothly.
What long-acting antihypertensive drugs are there?
1. Calcium channel blockers: nifedipine sustained-release tablets or controlled-release tablets, amlodipine or levoamlodipine and felodipine sustained-release tablets are commonly used antihypertensive drugs to maintain blood pressure in clinic. These drugs have reliable curative effects and are especially suitable for elderly patients with hypertension.
2.ACEI or ARB: Most powders and sartans are long-acting preparations, which can maintain blood pressure for a whole day once a day. Commonly used are enalapril, perindopril, ramipril, losartan, valsartan and irbesartan. It should be noted that captopril is a short-acting preparation, and the adverse reactions of sartan drugs are less than those of pril drugs.
3. Beta blockers: Metoprolol sustained-release tablets and bisoprolol are long-acting antihypertensive drugs, which are suitable for hypertensive patients with fast heart rate, but should not be used for patients with bronchial asthma or slow heart rate.
4. Diuretics: hydrochlorothiazide and indapamide are long-acting preparations with low price and good curative effect. Hydrochlorothiazide is forbidden in gout patients, and long-term use of diuretics may cause electrolyte disorder.
It is generally recommended to take antihypertensive drugs every morning to better control the morning peak blood pressure. The disadvantage of long-acting antihypertensive drugs is that they take effect slowly, and it usually takes one week to achieve the maximum antihypertensive effect. However, in case of hypertension emergency, short-acting preparations such as captopril or nifedipine tablets can be selected (phased out).
A good antihypertensive drug should meet two basic conditions: first, the antihypertensive effect lasts for a long time; Second, the fluctuation of blood drug concentration is small and the antihypertensive effect is stable. In addition, there should be fewer adverse reactions and good patient tolerance. If it not only lowers blood pressure, but also protects important organs such as heart and kidney, it will be even more icing on the cake.
At present, the commonly used antihypertensive drugs in clinic mainly include Puli angiotensin converting enzyme inhibitor, angiotensin 2 receptor antagonist of sartan, calcium channel blocker of horizon, β receptor blocker such as metoprolol, and thiazide diuretics such as low dose hydrochlorothiazide. Each kind of drug has a specific antihypertensive mechanism, and there are people who are most suitable for use, no matter who is good or bad. For example, Pulitzer or sartan drugs are most suitable for hypertensive patients with left ventricular hypertrophy or diabetic nephropathy, and β receptor antagonists are most suitable for hypertensive patients with increased heart rate and chronic heart failure. Due to the differences in chemical structure and pharmacokinetics, there are more or less differences in antihypertensive intensity and antihypertensive action time of each class of drugs.
Sartin
Among the sartans, telmisartan has a half-life of up to 20 hours, strong fat solubility and tissue permeability, higher affinity with AT 1 receptor, stronger antagonistic effect on angiotensin 2, and has the characteristics of potent and long-lasting effect. Although it has a long half-life and strong antihypertensive effect, it also has its disadvantages, that is, it takes four to eight weeks to reach the maximum antihypertensive effect. Therefore,
Powdered drug
Perindopril has the longest half-life of 30- 120 hours, followed by trandolapril and ranitidine. However, half-life is not the only factor that determines the duration and strength of antihypertensive drugs. The antihypertensive effect depends not only on the maintenance time of drug blood concentration, but also on the affinity of drug to tissue. Only when drugs have high affinity for tissues can they better inhibit different tissues (blood vessels, hearts, hearts). For example, compared with other varieties, enalapril with carboxyl group in its chemical structure has higher affinity for tissues, while captopril with sulfhydryl group and fosinopril with phosphate group have weaker affinity for tissues than enalapril.
Calcium channel blocker
Calcium channel blockers mainly include amlodipine, felodipine and nifedipine. Among them, amlodipine has the longest half-life of 30-50 hours, which can basically maintain 24-hour blood pressure control. Nifedipine controlled-release tablets adopt special controlled-release technology, and other drugs are released steadily and slowly within 24 hours. Theoretically, it can also achieve a stable and long-term antihypertensive effect for 24 hours. However, due to the controlled-release technology.
Beta receptor blocker
Among beta blockers, metoprolol and bisoprolol are commonly used. Metoprolol has different dosage forms, such as metoprolol tartrate and metoprolol succinate sustained-release tablets. Metoprolol succinate sustained-release tablets are the best. Metoprolol succinate sustained-release tablets can be released at an almost constant rate for about 20 hours, and the blood concentration is stable, which has a long-term and stable antihypertensive effect. Compared with metoprolol tartrate tablets, metoprolol succinate sustained-release tablets only need to be taken once a day, before and after meals, or in divided doses, while metoprolol tablets need to be taken 2-3 times before meals. Metoprolol tartrate is not useless. When patients with fast heart rate need to control their heart rate quickly, metoprolol tartrate takes effect faster and relieves symptoms more obviously than metoprolol succinate sustained-release tablets. Bisoprolol fumarate sustained-release tablets have higher selectivity to β 1 and β2 receptors than metoprolol succinate sustained-release tablets. When the heart rate needs to be controlled in the treatment of chronic heart failure, bisoprolol fumarate has a stronger inhibitory effect on cardiac β 1 receptor, which can control the heart rate more effectively, and has less influence on β2 receptor on bronchial smooth muscle. Therefore, bisoprolol fumarate has more advantages than metoprolol succinate sustained-release tablets in the treatment of chronic heart failure complicated with asthma and chronic obstructive pulmonary disease.
diuretic
At present, the diuretics used for lowering blood pressure in clinic mainly include thiazide diuretics such as hydrochlorothiazide and indapamide. Hydrochlorothiazide is rarely used as an antihypertensive drug alone, but it is usually used in combination with Pulitzer or sartan drugs because these drugs have adverse effects on metabolic factors such as blood sugar, blood lipid, uric acid and blood potassium. Therefore, thiazide diuretics are recommended to be used in combination with other drugs in small doses. Diuretics are suitable for senile hypertension, high salt intake, salt-sensitive hypertension and hypertension complicated with chronic heart failure, and are also one of the basic drugs for patients with refractory hypertension.
Hypertension is a chronic disease that cannot be cured at present, and it needs long-term medication to control blood pressure. Hypertension is mainly caused by aging, unreasonable diet, smoking and drinking, mental depression, heredity, and the increase of systolic and diastolic blood pressure caused by some diseases.
Hypertension for a long time, unstable control, will also lead to cardiovascular and cerebrovascular diseases, kidney diseases, fundus diseases and other diseases. So far, the drug treatment of hypertension is also a difficult problem. Some patients with hypertension have many complications and it is extremely difficult to take medicine. High blood pressure can lead to dizziness, headache, palpitation, numbness of limbs, chest tightness and other symptoms, and some have good blood pressure but the symptoms are not obvious.
On the basis of paying attention to diet and rest, it is best to recommend long-acting antihypertensive drugs, which is conducive to reducing the incidence of cardiovascular and cerebrovascular diseases. What long-acting antihypertensive drugs are suitable for everyone?
1. Diuretics (hydrochlorothiazide, indapamide, etc. ) is mainly used to reduce systolic blood pressure, mainly suitable for elderly patients with hypertension and heart failure.
2. Beta blockers (metoprolol, atenolol, bisoprolol) are mainly suitable for patients with heart failure, tachyarrhythmia, angina pectoris and myocardial infarction, but patients with asthma and diabetic peripheral vascular disease cannot use such drugs.
3. Calcium antagonists (nifedipine tablets, nimodipine tablets, amlodipine tablets) are beneficial to block the internal conversion of calcium ions and are suitable for patients with hypertension, coronary heart disease and arrhythmia.
4. ACEI and ARB drugs (telmisartan, valsartan) widely used at present have good curative effects on patients with diabetes, nephropathy complicated with hypertension, left ventricular dysfunction, heart failure and myocardial infarction.
Generally, the drug half-life of this kind of drugs is more than 24 hours, so the drug has long maintenance time and good curative effect, which can control blood pressure steadily and help prevent sudden death caused by hypertension at night and in the morning.