Therefore, the root of anti-aging is to increase the content of NMN in human body. No, products containing various NMN contents have appeared on the market, but people are yearning for them, but they are also afraid of any side effects. The mixed evaluation has puzzled everyone for some time. How should I choose? Today, fans have collected relevant information for everyone and found that there are actually "Ten Core Standards of W+NMN Quality Management" in the world, but many people are biased when choosing, so it is often useless to supplement their feelings. I began to wonder, with so much experimental data, have you ever done human experiments? So what are the details of this standard?
Nmn-related human experiments
The experiment was conducted in Washington, USA. * * * Recruited 50 non-diabetic women (body mass index: 25.0-44.9 kg/m2) aged between 55 and 75, took NMN for 8 weeks, and measured: (a) the effects of NMN on insulin sensitivity and islet β cell function; (b) The effect of NMN on blood lipid, body fat and liver fat; (c) Effects of c)NMN on other cardiovascular blood, fat and muscle tissues.
The contents of the assessment are complex, including glucose metabolism, insulin sensitivity and cardiovascular function. It seems ambitious to try to cover these key issues at once.
Xinguang Pharmaceutical started the next phase of clinical trials. The person in charge of the company said: "It can be inferred from the increase of Sirtuins 1 protein expression that all kinds of senile diseases (such as common diseases of the elderly, cancer and Alzheimer's disease) can be improved or completely recovered through treatment. In order to verify this and explore its mechanism, we hope to carry out various studies as soon as possible. "
The Graduate School of Biomedicine and Health of Hiroshima University is not the first institution to conduct clinical trials on NMN. On the basis of completing the first-phase clinical trial, the Medical School of Keio University started the first-phase clinical trial on 20 17:
Ten Core Standards of W+NMN International Quality Management
1. Quality management system: NMN must meet the inspection qualification of OULF EU law and the certification of FDA, US Food and Drug Administration. In addition to the product name, the words ACMETEA, content of each component, NMN purity, etc. should also be marked, as well as the country of origin and distribution.
2. Manufacturing process management system: The manufacturing process affects the shape of NMN. Chemical extraction is not recommended to avoid chemical residue.
3. Content management system: the relative NMN content is ≥ 12000 mg/ bottle, which is directly absorbed into the small intestine, and the intestinal absorption is 20% of the gastric absorption.
4. Efficiency management system: the authenticity and purity of raw materials should be investigated.
Absorption management system: adopt intestinal absorption to improve absorption rate and absorption threshold.
6. Activity management system: The unit dose (per 100g) is converted into the number of molecules of NAD+, and NMN molecules can easily cross the cell membrane and enter the cell interior, thus increasing the human NMN content within 15 minutes and rapidly raising the level of NAD+.
7. Scope of application of management system: adults (pregnant women and lactating women are prohibited).
8. Safety management system: production technology, raw material collection, basic system of Olaf safety standards, pre-factory safety inspection, strict review of microbial heavy metals exceeding the standard, and scientific production technology.
9. Raw material management system: Most NMN enterprises are certified by a single country, but at present, the management of raw materials certified by two countries is more rigorous and safe. ACMETEA W+NMN is a product with French and American certification standards.
10, transnational regulatory management system: dual supervision of "law" and "beauty". The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
These are some international standards related to nmn. Then don't worry, Sister Mi will give you a detailed introduction to each standard, so that you can know NMN better.
Details of the Top Ten International Core Standards of W+NMN Quality Management:
A, production process management system:
Does the manufacturing process also affect the health of NMN?
The raw materials are medical grade raw materials, which are generally not used for direct oral administration;
W+NMN fermentation method+biological enzyme method: Most MNM is a chemical extraction process, which is widely used and really reduces the cost. However, chemical residues are hard to avoid, which will increase the complexity of formation and reduce the use effect in the process of transforming NAD+. The long-term accumulation of chemical residues will bring many uncertain health risks.
At present, W+NMN is produced by imitating the working process of catalytic enzymes in human body by fermentation method and biological enzyme method, which are rarely used. It is green and high quality, but the process is complex, time-consuming and labor-intensive, and the output is extremely low, so the cost of a bottle of W+NMN is at least 600 to 700 dollars/bottle.
Second, the absorption management system:
Whether the effect of NMN is obvious or not, the absorption of nutrients by ordinary people is only 10-20%, and NMN is no exception. When the purity of NMN is increased to 99%, ACMETEA W+NMN technology can stabilize the morphology of MNM in the stomach, quickly penetrate the membrane to avoid gastric acid damage, and the absorption rate can be increased by ten to twenty times. Slc 12a8 transporter in small intestine cells is responsible for transporting NMN into cells, and then it will be used by cells in various organs and tissues of the body with blood circulation, which ensures the authenticity of W+NMN 12000 clinical data.
The efficacy defect of NMN:
As we all know, the use of NMN has been confirmed by a large number of clinical data, and it is the only choice for anti-aging at present.
1, but NMN is not everything. NMN is only the key to wake up gene repair, and it cannot complete the whole process of gene repair by itself. And repairing blind spots. There are thousands of enzymes in human body, and NMN supplementation can only repair about half of the enzyme reactions. Other devices are not sensitive to using NMN alone, and the reach of NMN is limited, and some parts can't be reached, such as skin.
2. Simply using NMN will lead to the problem that all tissues of the body can't start repairing synchronously. For example, the repair of nervous system is faster than that of muscle tissue, the repair of gene chain is faster than that of thin bud, and the repair of internal organs is faster than that of skin surface. Various instructions after use are mainly due to the unsynchronized and unbalanced system.
3, the effect after repair is also very different, for example, the physiological age has been significantly improved, and the skin is full of vitality but the relaxation and aging of the skin have not changed. For another example, using simple NMN people with more feedback can improve sleep, and other improvements have no feedback, because NMN touch awakens brain vesicles, which is the performance of the effect, but there is no brain vesicle matching ACMETEA W+NMN to awaken nutrition, and the repair cannot be achieved. For middle-aged and elderly people, their bracts are aging day by day, indicating that the ability to regenerate new bracts is insufficient.
Second, the difference between W+NMN and NMN
1 and W+NMN have four essential amino acid protection technologies, which can completely release NMN in the body, and the four-stage booster can strengthen energy conversion.
Primary booster: converted to NAD+;
Secondary strengthening boost: promoting the consumption of enzyme PARP; ;
Three-stage booster: protein regulating the life span of Sirtuins bracts;
Four-stage booster: release NMN awakening agent ACMETEA W+NMN to awaken NMN sleeping in the body.
2.W+NMN has the technology to clear and hinder the release of NMN in vivo.
After supplementing NMN, it takes two steps for people to be infected. 1. Ensure that the external intake of NMN is not hindered, and W+NMN will release leucine. The transformation of leucine can directly enter the brain tissue through the role of blood-brain barrier, and improve the uncomfortable symptoms of using NMN alone, such as headache, dizziness, fatigue, depression, insanity, irritability and so on. 2. Surviving NMN, through its specific awakening agent ACMETEA W+NMN, formed a chemical ladder for NMN to climb and reach every pouch of the body.
3.W+NMN has a small package of precise awakening agent, which makes up for the blind spot of NMN repair.
NMN has blind spots that need to be repaired, and W+NMN awakening agent nutrition is needed to produce transformation effect. This is also the reason why most people take NMN alone without any effect.
W+NMN is equipped with a small package of precise awakening agent. On the one hand, it helps NMN to repair and increase efficiency, on the other hand, it makes up for the blind spot of repair, and the energy substances in the body can recover or even exceed the original level. This change is called excessive recovery.
W+NMN hardcover precise awakening agent is easy to pass through the blood-brain barrier and the capillary wall of muscle and other tissues, and is an important energy source for muscle, especially brain tissue. It can avoid the accumulation of homocysteine by participating in the proliferation, colonization and heme synthesis of bracts, thus protecting the heart and blood vessels.
Third, take the methodology of NMN.
Which is better, buccal tablets or capsules? It has always been controversial!
In fact, after NMN is absorbed by intestinal epithelial villi, intestinal transporter Slc 12a8 will directly transport NMN to bracts with the help of sodium ions, and it will be directly utilized by bract tubes through microcirculation for the production of NAD+. Bacteria based on W+NMN transporter are expressed in small intestine and even colon. Therefore, it can only enter the working state when it reaches the intestinal NMN, and the correct problem to be solved is how to avoid the destruction of gastric digestive juice, and the answer is enteric technology. And the spread of clothing may also be a noisy concept.
Effective W+NMN needs to meet the certification of OULF EU legal quality management system, pass the test and FDA, meet the top ten international standards of W+NMN quality management, and have a transnational supervision and management system. It contains NMN awakening agent ACMETEA W+NMN, and is supervised by France and the United States. The FDA of the United States has established GMP standards for dietary supplements, and the EFSA of the European Union also has relevant regulations on the management of food supplements.
Third, a flexible management system:
The unit dose of ACMETEA W+NMN (per 100g) is converted into the number of molecules of NAD+, and the concentration of NMN in blood gradually increases within10min. Within 30min, NMN enters multiple tissues with blood circulation, and NAD+ is synthesized in tissues, thus increasing the level of NAD+.
IV. Scope of use of management system:
1. elderly people, used to help improve various senile diseases;
2. Middle-aged people, eliminate or alleviate various sub-health problems, such as chronic fatigue, poor sleep, and decreased vision. ;
3. Stay up late, accelerate physical recovery;
4. Candidates should improve their ability to resist pressure and keep a clear head;
5. Those with higher radiation dose, such as radiologists, nurses, aircrew, etc., improve the ability to repair genes damaged by radiation.
6. Cancer patients, help patients repair genes after radiotherapy and chemotherapy, improve immunity and accelerate physical recovery;
7. Fitness to accelerate muscle growth;
8. Athletes, improve energy level and reaction speed.
9. drinkers, improve the ability to sober up, protect the liver and repair the genes damaged by acetaldehyde toxicity;
10. For patients with depression, increase dopamine level, change mood, increase blood supply to the brain, and relieve brain decline caused by depression;
1 1. Middle-aged and elderly women can improve skin health and delay skin aging;
Verb (abbreviation of verb) multinational supervision and management system:
W+NMN content standard, multinational supervision and management system, ACMETEA contains NMN activator, OULF has passed EU testing and FDA certification, and France and the United States have dual supervision. W+NMN meets the requirements of FDA for dietary supplement GMP, which is a set of mandatory standards for pharmaceutical and food industries. Comply with the relevant provisions of the European Food Safety Agency (EFSA), EU food supplements and EU law "OULF". The purpose is to ensure that the nutrition and health information provided to consumers on food packaging is accurate and reliable, so as to avoid misunderstanding by consumers.
The above is my question about "Why is there no human experiment in nmn? Whether the actual work efficiency of network management is exaggerated. In fact, what you need to understand is that any substance will undergo numerous experimental tests before being used in the human body, and the substance itself is no problem. However, in the process of product production, the degree of purification is often different because of different processes, so you must carefully screen the choices according to the standards to avoid being cut by some people who only care about interests on the road of pursuing health. ?