Folic acid metabolism test, what does the heterozygous mutation of gene mthfrc677t mean?

This mthfr gene test is often used in pregnancy examination, reproductive center, neurology, cardiology and oncology. It is to detect the metabolic ability of methylenetetrahydrofolate reductase. Normal MTHFR activity can maintain the effectiveness of folate methionine cycle and ensure the normal synthesis and methylation of DNA. If the activity of MTHFR enzyme changes, it will lead to the disorder of 5- methyltetrahydrofolate production, abnormal DNA synthesis and methylation, hyperhomocysteinemia and many genetic diseases. Among them, there are three genotypes, namely CC type, CT type and TT type. CC indicates enzyme activity 100%, CT indicates enzyme activity 65%, TT indicates enzyme activity 30%, and TT+ indicates lower enzyme activity. Of course, it's all a question of probability. Some detect genotype CC, but related genetic diseases will still occur, which is caused by late mutation. Some TT+ will also appear disease-free. However, testing is high-risk, so it is suggested to pay attention to life and diet according to the doctor's rhythm and reduce the chance of mutation. I wish you the best of health!