In 2001, she became the spokesperson of Christian Dior Lipstick Seductive Ball in Asia; in 2001, she played the role of More Sa in the TV series "Scars of Strong Love".
In 2001, she was selected as a jury member of the 4th Duvel Asian Film Festival in France.
In 2005, she was chosen as the spokesperson of Hong Kong Shopping Festival.
In 2005, was the first Asian star to headline the 10th anniversary world tour of the hit Broadway musical "Gigolo" and portrayed Karen Mok in episode 8 of the TV series "The Diary of Old Feng".
In 2007, she won the Best Mandarin Album award at the 19th Taiwan Golden Melody Awards for her debut album "La vie...Karen Mok", the first Hong Kong female singer to win the award. In the same year, Karen Mok's song "Hiroshima Love" won the first place with 20011 votes in the "100 Classic Duet Songs Voting Activity" on Taipei Voice FM107.7.
In 2008, she signed a contract with the Hollywood company CAA, along with Beecham and Bibbitt, and was the first Hong Kong female artist to join this large international management company, and was described by the American film magazine Hollywood Reporter as one of the "most successful actresses in Asia". In the same year, Karen Mok's album "Karen Mok on the 12th Floor" was selected as one of the top 100 albums in Taiwan pop music from 1993 to 2005 by the Association of Chinese Musicians Exchange and ranked 60th. And participate in the Beijing Olympic Games countdown to the Olympic 100 days party, the opening ceremony and closing ceremony with Joey Yung have literary performance; Karen Mok also in Yichang City, Hubei Province, as the 159th torchbearer, the only Hong Kong artist in mainland China as a torchbearer within the territory of Hong Kong.
For three consecutive years in 2010, 2011 and 2012, she was ranked in Forbes Magazine's "China's Top 100 Celebrities Power Ranking", and won the first place in the Hong Kong female singers and actresses category in 2011 and 2012 consecutively.
In 2013, for the 20th anniversary of Karen Mok's debut, held in September at the Landmark, "after the era of Mo - Karen Mok 20th anniversary exhibition", and in November began to tour concerts, touring concerts in 14 cities held 25, breaking Karen Mok's personal record for the number of concerts, and into the mainland personal concerts the number of Hong Kong female singers most third (the first two respectively for Anita Mui, Lin Yilian). Chongqing station highest ticket price of RMB 3,680, refresh the Chinese female singer highest ticket price record. 2016 January 18, "Chinese diva" Karen Mok "Mo after the age of" global tour was a great success, the new 2015 "Look at the world" tour kicked off on September 19, 2015 in Taipei. January 16, came to the Mercedes-Benz Cultural Center in Shanghai, and set the highest record of the venue's three-sided stage single-session audience total of more than 11,000 people.
In February, to celebrate her first major tour in Europe, the three European cities hosted a special press conference in London to welcome Karen Mok, and invited key European media to attend.
July, the premiere of Hunan TV's "Here We Come", a celebrity goddess life experience show
October, the premiere of "Heavenly Melody Battle", an Oriental TV music challenge variety show
.