193 1 spring, he was born in an old intellectual family. In the year when New China was founded, he entered the Medical Department of Shanghai Medical College to study. 1953, and went to the information class of senior teachers in the Institute of Pathology, Sun Yat-sen Medical College for another year. 1954 After graduation, he was assigned to the Department of Pathology, School of Medicine, Shandong University as a teaching assistant. 65438-0956 transferred to the Department of Pathophysiology of Hunan Medical College to teach. With the talent of "diligence and cleverness", he mastered English, Russian, German and three foreign languages when he was a student. After joining the work, I taught myself Japanese and French. Professionally, he is a generalist, familiar with pathophysiology, experimental oncology, molecular biology, biochemistry, mathematical statistics, experimental design, etc., and has shown superhuman talent very early. But I didn't expect that from 65438 to 0958 overnight, he became a typical example of "taking the white road" and was repeatedly criticized. The most painful thing was that he lost the freedom to pursue his career. Soon after, when he was assigned to do experimental tumor research and achieved gratifying results, he encountered an unprecedented "cultural revolution". It was not until 1976 that he rejoined the experimental tumor. At this point, his good years have been consumed for a long time. But he cherished this hard-won working environment and decided to spend the rest of his life to conquer nasopharyngeal carcinoma. After the Third Plenary Session of the Eleventh Central Committee of the Communist Party of China, Yao Kaitai was like a duck to water, not only making rapid progress in his career, but also becoming more and more mature politically. Despite all kinds of grievances, his patriotism has never changed, and his belief in the socialist cause and the * * * production party has not changed. 1982, when he attended the 13 international cancer conference in the United States, he saw the KMT flag on the podium and immediately withdrew from the conference, and immediately made solemn representations to the conference host through the team leader. Later, the host apologized to them and took down the flag of the Kuomintang. Only then did I return to the venue and safeguard the interests and dignity of the motherland with my own actions.
1June, 983, Yao Kaitai was honored to join the China * * * Production Party and realized his long-cherished wish. Under the training and education of the organization, he got closer to his career and deepened his understanding of the party's socialism. 1990 was awarded the Excellent party member in Hunan Province. 199 1 academically, he ascended the highest academic hall in China-he was elected as a member of the Biology Department of China Academy of Sciences, and later renamed as an academician of China Academy of Sciences. 1992 was elected as the delegate to the14th national congress of China * * production party.
A famous person once said: the value of life can only be realized through struggle. It is in decades of unremitting struggle to conquer cancer that Yao Kaitai found his highest value. He contributed a lot of scientific research achievements to the society, and also showed the noble character of China intellectuals' unique persistence in science and indifference to Zhi Ming. When their work "Culture of human embryonic nasopharyngeal epithelial cells, chemical transformation and cloning of malignant transformation genes of nasopharyngeal carcinoma" won the second prize of the National Science and Technology Progress Award 1996, and "Localization of DNase- 1 sensitive regions on human mitotic chromosomes" won the second prize of the Ministry of Health, people congratulated him one after another, but he said modestly, "I just did what I should do." "I am a college student trained in New China. Under the guidance of the correct line of the Third Plenary Session of the Eleventh Central Committee of the Party, I have done a little bit of work in the great changes that have taken place in China. Every time I think about it, I'm on pins and needles. The past has passed, and the future can be pursued. Only by strengthening study and working hard can we continue to do our bit to revitalize China and develop science and education in China. " 1987, after Dolly, a British cloned sheep, was born, someone asked Professor Yao Kaitai: "What is the significance of cloned sheep technology to tumors?" I want to ask him to write an article. The essence of cloned sheep is nuclear transplantation technology. He opened the information superhighway. Although he seldom saw information about him, he gained unexpected gains. He found that a scholar in Minnesota, USA, had done a meaningful experiment with leopard frog many years ago: he transplanted the nucleus of renal cell carcinoma caused by herpes virus into enucleated fertilized eggs, and as a result, it developed into a tadpole, but it didn't grow up and died soon. Although this experiment failed to continue, it shows that cancer cells can be reversed, but this reversal is limited because cancer cells are different from normal cells after all. Professor Yao was inspired by this: malignant cells can be reversed. Why? The activated egg cells have changed the nucleus. Factors in the cytoplasm must have influenced the transplanted nucleus and reversed it. Can you clarify these factors and further separate them? This is an important question that Professor Yao Kaitai has to answer in the fight against cancer.
From 65438 to 0994, Yao Kaitai personally established the Key Laboratory of the Ministry of Health, which was originally intended to jointly study development and tumors with relevant units. However, due to the late start and other reasons, it failed to apply to the State Key Laboratory, so the "Tumor Principle Laboratory of the Ministry of Health" was established to carry out molecular research. There are two state key laboratories for tumor research, one for esophageal cancer research and the other for liver cancer research. Yao Kaitai conducts basic research on nasopharyngeal cancer. Professor Yao said meaningfully: "We are struggling. We have been in Gai Lou for more than three years, and the Ministry of Health has only invested 80,000 yuan; " The school spent 400 thousand yuan to finally solve the housing problem for us, solved 10 staff, and invested 1 10 thousand yuan in operating expenses every year. The rest have to apply for projects themselves to get funds. Now the project responsibility system is implemented, and whoever applies for the funds will use it. China's basic theoretical research has too little investment and high requirements. This is a practice of' telling the horse to run and telling the horse not to eat grass', which makes us have many difficulties. 1997 we will have no money to use. "
In the operation of market economy, scientists engaged in basic theoretical research have encountered more confusion. However, Yao Kaitai, whose temples are white, remains elegant. He is not afraid of difficulties and will continue to fight for his career.
1998, Yao Kaitai, who is nearly ancient and rare, came from Changsha to Guangzhou First Military Medical University (now renamed Southern Medical University). Under the leadership of Yao Kaitai, the nasopharyngeal carcinoma research group of Southern Medical University created a "visualized animal model of nasopharyngeal carcinoma metastasis" for the first time, which laid a solid foundation for studying the metastasis law of nasopharyngeal carcinoma and drug screening. In addition, Yao Kaitai is also the director of the Academic Committee of the Key Laboratory of Histology in protein, Guangdong Province, the director of the Guangdong Institute of Pharmaceutical Industry, the director of the South China Primate Research and Development Center in Guangdong Province, and the director of the Academic Committee of the Key Laboratory of Cancer in protein, Ministry of Health.
From 65438 to 0999, after several efforts, the Institute of Oncology applied for CMB project again, and Yao Kaitai got a sub-topic: the research on transgenic animal model, which received more than 70,000 US dollars in funding. Although this is a hard bone to chew, it is meaningful, because the actual work has entered the fourth generation of genetic technology-transgenic animal level research.
In mid-June, 2000, when Yao Kaitai attended the 8th International Conference on EB Virus and Tumor in Stockholm, Sweden, he had a special discussion with Dr. Geoge Klein, an expert on EB virus and tumor in Kalulin University. Dr Geoge Klein believes that in the past 20 years, the research on nasopharyngeal carcinoma in the world has made little progress, mainly due to the lack of animal models and the difficulty in obtaining cell lines at different stages of carcinogenesis. In fact, these are all topics that Yao Kaitai has been committed to for a long time.
Later, Yao Kaitai applied for the key project of the National Natural Science Foundation: "Study on Molecular Biological Characteristics of Nasopharyngeal Carcinoma", with a funding amount of 500,000 yuan, and the school also provided an equivalent funding of 500,000 yuan, which has been put in place one after another. Professor Li Guiyuan also has the sub-project of "863 Program", and Professor Cao Ya has the projects of National Natural Science Foundation and Outstanding Youth Fund. This will make life easier from the perspective of funds, but it is not difficult to check the airport. Mainly solve the problem of molecular biological characteristics of nasopharyngeal carcinoma precancerous lesions. But I just can't get the specimen of the precancerous lesion of nasopharyngeal carcinoma. Not only can we not find precancerous specimens here, but once we find that there is something wrong with the nasopharyngeal carcinoma, it is the advanced stage of nasopharyngeal carcinoma. The problem is that some clinical experts don't admit the disease at all in clinic, so it is difficult to cooperate. They had to find their own way, that is, to design and transplant the nasopharyngeal part of human embryos into an animal-mice with severe combined immunodeficiency, and then start experimental research on cancer induction from here. There is no doubt that this is a risky experiment. Fortunately, under the guidance of Professor Yao Kaitai, Dr. Li and Dr. Ling Jianhua, who are working in the post-doctoral mobile station, obtained the tissue-specific gene fragments of human and mouse nasopharynx respectively, but the goal is to clone the whole gene-full-length sequence, and the work is still in progress.
Professor Yao told his students: "To study the pathogenesis of nasopharyngeal carcinoma, we need to focus on the future." Not long ago, Ren Xu and his doctor who got his degree from Hunan Medical University recommended a promising animal-Xenopus laevis to their foreign teachers. They have introduced and propagated this African "frog" and are cooperating with Xu Renhe to observe the influence of genes on development and differentiation. They are about to inject the late embryos of Xenopus laevis and observe the results, so as to establish a set of methods to study the function of genes and thus study the activity of genes as a whole. "As time goes on, we can expect to seduce a place."
Speaking of this, Professor Yao Kaitai is full of confidence in the future. He said: "The country has awarded the title of' Senior Academician' to academicians over 80 years old, but I still have 10 years of working experience. I still have to create conditions and strive to do more work and do better. "
In addition, in Southern Medical University, I often see this white-haired old man active on the podium, tirelessly telling students about the infinite mysterious tumor world and cultivating new seedlings for scientific research and development.
Scientific research and teaching are correct, and Mr. Yao has always been in the front line.
Now, it's time for Yao Kaitai to rest and enjoy his children and grandchildren. But his mind is still on his career, designing higher climbing goals.
What a white head!