Drug prescription embodies the characteristics of active intervention and multi-target treatment.
Eliminating plague by connecting flowers is to explore the law and treatment of exogenous fever and plague by using the theory of collateral diseases in traditional Chinese medicine, and put forward the countermeasures of "active intervention": treating both health and qi, treating both exterior and interior; Take medicine first and get sick; Formulated the treatment plan of overall regulation, multi-target treatment, "clearing away plague and detoxifying, dispersing lung and clearing heat". This prescription absorbed the essence of medicine used by doctors in past dynasties to treat exogenous fever and epidemic diseases, applied Maxingshi Dry Decoction in Treatise on Febrile Diseases and Yinqiao Powder in Treatise on Febrile Diseases, and learned from the experience of rhubarb in treating epidemic diseases in Treatise on Febrile Diseases by Wu Youke in Ming Dynasty, and cooperated with Rhodiola to clear away lung heat, remove blood stasis and regulate immunity, which embodied the characteristics of active intervention.
Rhubarb is used to clear the plague, and the lungs and large intestine are on the surface, so that the "epidemic poison" is discharged from the stool, and the evil spirits have a way out; Another value of using rhubarb is to take medicine first and stop the disease. In Ming Dynasty, Wu Youke once pointed out that the plague treatment should attack evil as soon as possible before the healthy qi of human body fails, and the application of rhubarb in advance can cut off the spread of the disease to the critical condition. Modern pharmacodynamic studies have confirmed that rhubarb can inhibit lung inflammation and improve lung function. Use the fragrance of Pogostemon cablin to remove dampness, avoid filth and remove turbidity. At this time in COVID-19, there is a prominent feature, that is, it is wet, turbid and poisonous, especially in Hubei epidemic area, which is wet and cold. The patient showed loss of appetite and sticky stool. Pogostemon cablin can avoid filth and turbidity, and improve anorexia and wet spleen and stomach. Rhodiola rosea, which grows in cold and high altitude areas, has the functions of tonifying lung, relieving asthma and promoting blood circulation, and can improve the anti-fatigue and hypoxia tolerance of human body. At the same time, the immune enhancement of Rhodiola can improve the decline of patients' disease resistance and improve the body's disease recovery ability.
Inhibit cold virus
Many professional organizations in China have found that lotus has the advantages of overall regulation and multi-target play. For common cold virus, Chinese Academy of Traditional Chinese Medicine and other scientific research institutes have found that Lianhua Qingwen has inhibitory effects on respiratory syncytial virus, parainfluenza virus, rhinovirus, adenovirus and herpes simplex virus, especially on common colds such as respiratory syncytial virus and parainfluenza virus.
Inhibit a variety of influenza viruses
As for influenza virus, basic research by Guangzhou Institute of Respiratory Diseases, Chinese Academy of Traditional Chinese Medicine and other scientific research institutes has confirmed that Lianhua Qingwen has obvious inhibitory effects on influenza A H 1N 1, H3N2, avian influenza H5N 1, H9N2, H7N9 and influenza B virus, among which it has a strong inhibitory effect on influenza A H3N2 virus prevalent last winter and this spring.
Suppress novel coronavirus
For this year's epidemic novel coronavirus, the team of Academician Zhong Nanshan from the State Key Laboratory of Respiratory Diseases of Guangzhou Medical University found that Lianhua Qingwen had a good inhibitory effect on cytopathic effect caused by common coronavirus (HCoV-229E) and novel coronavirus (coronavirus pneumonia-19). In addition, Lianhua Qingwen can also inhibit the expression of TNF-α, IL-6, CCL2/MCP- 1 and CXCL- 10/IP- 10 caused by HCoV-229E and coronavirus pneumonia. Lianhua Qingwen showed antiviral and anti-inflammatory effects on novel coronavirus at the cellular level, which brought hope for the treatment of novel coronavirus infection.
Anti-inflammatory and antibacterial effects
Lianhua Qingwen can also effectively inhibit a variety of bacteria, with good anti-inflammatory effect, which is conducive to the treatment of mixed infections. The Chinese Academy of Traditional Chinese Medicine, Hebei Medical University, Nanjing University of Traditional Chinese Medicine and other institutes have found through many studies that Lianhua Qingwen Capsule has inhibitory effects on Staphylococcus aureus, hemolytic streptococci A and B, pneumococcus, influenza Bacillus, etc., and can prevent bacterial infections secondary to colds and influenza, and effectively prevent the occurrence of complications such as bronchitis, pneumonia and tonsillitis. More importantly, the researchers also found that Lianhua Qingwen can kill bacteria in bacterial biofilm, and can obviously inhibit the number of live bacteria in biofilm, which brings dawn to crack bacterial drug resistance.
Cough-relieving and phlegm-resolving effects
Lianhua Qingwen capsule also has obvious antitussive and expectorant effects. Experiments of Hebei Medical University and Nanjing University of Chinese Medicine confirmed that Lianhua Qingwen Capsule can promote the secretion of phenol red in trachea, prolong the cough latency and cough times caused by ammonia water and citric acid in mice and guinea pigs, and has obvious antitussive and expectorant effects.
Lianhua Qingwen has high safety in treating cold and good effect in early use.
The inhibition and killing effect of Lianhua Qingwen capsule on many cold viruses determines its advantages in treating colds. The medicine is a pure Chinese medicine preparation, which can dispel the internal heat of human body by sweating gypsum, Rhizoma Osmundae, Flos Lonicerae and Fructus Forsythiae, so that the internal basis of fever disappears, and the body temperature naturally drops without rebounding. The medicine has antibacterial, anti-inflammatory, antitussive and expectorant effects. If you take it as early as possible and eliminate toxic fire by expelling wind and relieving exterior syndrome and clearing away heat, there will be no complications such as bronchitis and pneumonia.
Evidence-based evidence of Lianhua Qingwen in the treatment of influenza
The research and development of Lianhua Qingwen is mainly aimed at influenza. In the high-incidence season of influenza every year, Lianhua Qingwen has played an active role in the prevention and control of influenza in China, and evidence-based medical research evidence has also been obtained for the treatment of influenza. In 2009, Beijing You 'an Hospital affiliated to Capital Medical University and 9 influenza A hospitals conducted an evidence-based medical research on "Lianhua Qingwen Capsule for treating influenza A H 1N 1". Patients in the experimental group took Lianhua Qingwen capsule according to the standard treatment amount every day, while patients in the control group took oseltamivir capsule. The results are encouraging: First, Lianhua Qingwen Capsule has no difference with oseltamivir in antiviral effect. Second, Lianhua Qingwen Capsule is superior to oseltamivir in relieving flu symptoms, especially in relieving cough, headache, muscle aches, fatigue and other symptoms. The influenza type this year is mostly H3N2. Lianhua Qingwen has obvious inhibitory effect on this virus, and it also has a good effect on other types of influenza viruses. Academician Zhong Nanshan once pointed out: "In the most rigorous double-blind evidence-based medical research recognized by Dr. Lin Yi, Lianhua Qingwen has shown an effective therapeutic effect in relieving the symptoms of influenza patients, especially for patients with high fever symptoms." Academician Zhong Nanshan believes that the anti-virus concept of traditional Chinese medicine is different from that of western medicine. Traditional Chinese medicine has the function of systemic regulation, which is its characteristic and strength. We must pay attention to the flu, clear the plague with Lianhua as soon as possible, and strive for time to get effective treatment, so as not to delay the illness.
Lianhua Qingwen capsule can not only treat influenza, but also prevent influenza, which has been confirmed by large-scale application. On September 4th, 2009, the Health Bureau of Langfang City, Hebei Province reported that a cluster case of influenza A (H 1N 1) occurred in the university town of the development zone of this city, and the prevention and control expert group quickly isolated more than 20,000 close contacts of the confirmed patients and their surrounding healthy people. Among the isolated population, 6367 people chose to take Lianhua Qingwen for prevention, 1 177 people chose other drugs for prevention, and 13009 people did not take drugs for prevention. The results showed that the infection rate of the prevention group without drugs was higher, the infection rate of the prevention group with other drugs was in the middle, and the infection rate of the prevention group with Lianhua Qingwen was lower, which proved that Lianhua Qingwen Capsule had reliable preventive effect on influenza.
Lotus has played an important role in the prevention and control of COVID-19.
The fourth to seventh editions of the Diagnosis and Treatment Plan for Pneumonia Infected in novel coronavirus issued by National Health Commission and state administration of traditional chinese medicine recommend taking Lianhua Qingwen Capsule and Granule for preventing and treating fatigue and fever of patients during medical observation. Up to now, Lianhua Qingwen has been used by about 70 million people in China and millions of people in Hubei Province. Lianhua Qingwen is also used as a basic medicine in all hospice hospitals in Wuhan. Hubei Province, Heilongjiang Province and other provinces and cities use Lianhua Qingwen Capsule/Granule as a reserve medicine, and the Ministry of Industry and Information Technology listed it as a medical emergency support material in the list of key support materials for epidemic prevention and control.
The clinical application of Lianhua Qingwen in many hospitals in epidemic areas, including Fangcang Hospital, shows a good effect of obviously improving symptoms such as fever, cough and fatigue. On the basis of routine treatment, Puren Hospital affiliated to Wuhan University of Science and Technology used Lianhua Qingwen Granule to treat 54 patients with COVID-19. The results show that Lianhua Qingwen Granule can obviously improve the symptoms of fever, cough and fatigue of ordinary patients in COVID-19, and shorten the duration of fever, fatigue and cough, which provides a research basis for clinical treatment of this disease.
Overall adjustment plays a palliative role.
Although Lianhua Qingwen has anti-virus effect, the basic treatment of Lianhua Qingwen is overall regulation and multi-target treatment. Aiming at a symptom of exogenous fever, such as fever, cough, phlegm, sore throat, fatigue, muscle pain and so on. The mechanism of action lies in the synergistic effect of anti-inflammatory, anti-virus, relieving cough and asthma, and enhancing the immune function of the body. As long as the symptoms are the same, whether it is common cold, flu or COVID-19, it can be treated with Lianhua Qingwen, which is the characteristic of Chinese medicine.
From influenza A, influenza B and avian influenza to novel coronavirus, Lianhua Qingwen has been recommended by the national treatment plan in all major viral public health incidents in China in recent ten years, and it has been included in the Guidelines for Influenza Diagnosis and Treatment, the Diagnosis and Treatment Plan for Human Infected with Influenza A H1N/KLOC-0, the Prevention and Treatment Plan for Influenza B with Chinese Medicine and the Diagnosis and Treatment Plan for Human Infected with H7N9 Avian Influenza. After many times of epidemic prevention and control, Lianhua Qingwen has been selected as a reserve drug in many places and has become a representative drug to deal with infectious public health incidents in China.
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