For a time, phenolphthalein tablets and phenolphthalein buccal tablets were pushed to the forefront.
Many people who have used or are using phenolphthalein tablets and phenolphthalein buccal tablets are worried about their health problems. Many people don't understand: after all, it is an old medicine that has been used for a long time, and suddenly it is told that there are serious adverse reactions. What is this?
People with frequent constipation should be familiar with phenolphthalein tablets. Phenolphthalein tablets, also known as guide tablets, mainly act on colon. They are stimulating laxatives, mainly used to treat habitual constipation and intractable constipation.
After phenolphthalein tablets enter the human body, they will be decomposed by small intestinal fluid to form soluble sodium salts, which will increase gastrointestinal peristalsis, produce laxative effect and finally promote defecation. Phenolphthalein tablets were popular in the streets a few years ago because of their cheap price and quick effect. In order to make huge profits, some businesses even add phenolphthalein tablets to diet pills and sell them to people who need to lose weight.
Although phenolphthalein tablets have a good laxative effect, they need to be used under the guidance of a doctor because they are clinical prescription drugs. In addition, phenolphthalein tablets have strict indications, and long-term overdose may cause a series of adverse reactions.
1954, a two-and-a-half-year-old girl suffered from mild diarrhea accompanied by convulsions in her right face and right arm because she ate too many chocolate laxatives containing phenolphthalein. After being rushed to the hospital for treatment, the girl still has persistent myoclonic epilepsy and sometimes generalized epilepsy. Eventually, the girl lost consciousness and died in a coma. The doctor speculated that the girl's death may be related to encephalitis caused by phenolphthalein allergy.
With the increasing frequency of phenolphthalein use, there are more and more cases of adverse reactions.
Clinical research shows that phenolphthalein contains irritating components, which may cause gastrointestinal mucosal inflammation, such as dermatitis and enteritis, and even cause electrolyte metabolism disorder, induce arrhythmia and threaten life safety.
These are not the most deadly. What makes phenolphthalein completely denied is that a survey in the United States shows that people who use phenolphthalein laxatives for more than 350 times have a risk of developing intestinal cancer 3.9 times that of ordinary people. This means that phenolphthalein is potentially carcinogenic. Subsequently, more and more studies have proved that long-term use of phenolphthalein does increase the risk of cancer.
With the accelerated pace of life, people's lifestyle has also changed to a certain extent. Bad lifestyles such as high-fat diet, lack of sleep, excessive stress and lack of exercise have made more and more people suffer from constipation. In order to relieve the pain of constipation, some people began to use laxatives, tasted the sweetness, and gradually became dependent, resulting in the situation that "without the help of laxatives, they could not pull it out at all". But the abuse of laxatives in constipation is extremely harmful.
On the one hand, some laxatives containing strong laxatives basically contain anthraquinone. Anthraquinones can cause pigmented lesions of colon mucosa, lead to melanosis of colon and increase the risk of colon cancer.
On the other hand, the abuse of laxatives will also damage the intestinal motility, making the intestine dependent on laxatives, which is not only not conducive to improving constipation, but also makes the colon motor function disorder, eventually leading to constipation without laxatives, resulting in a vicious circle.
Laxatives should not be abused or misused. At present, laxatives commonly used in clinic include lactulose, polyethylene glycol 4000 powder, castor oil and kaisai dew. Generally speaking, for patients with functional constipation, priority should be given to adjusting eating habits and changing defecation habits to relieve constipation. When the basic treatment fails, consider using drugs as appropriate, instead of using laxatives as soon as constipation occurs.
Besides phenolphthalein, the following three drugs have been banned in many places. We should be more careful before taking medicine.
1. An Naijin
Analgin is a mixture of aminopyrine and sodium sulfite, which belongs to antipyretic and analgesic drugs. At present, more than 30 countries, such as the United States, Japan and Australia, have eliminated Anakin because of its side effects. In March last year, the State Administration of Pharmaceutical Products also issued an announcement to stop the production, sale and use of metamizole sodium injection, metamizole sodium chlorpromazine injection and pediatric metamizole sodium enema in China, and to cancel the drug registration certificate.
The side effects of metamizole sodium are as follows: first, it can cause agranulocytosis; Second, it causes skin allergic reactions such as urticaria and exudative erythema; Third, it can cause anaphylactic shock, which can lead to death in severe cases.
2. Pidotimod preparation
Pidotimod preparation was once called "pediatric medicine", which is suitable for the adjuvant treatment of chronic or recurrent respiratory tract infections and urinary tract infections. However, due to the possible side effects of Pidotimod preparation, such as damage to digestive system, skin and its accessories, damage to nervous system, etc., the US Food and Drug Administration issued a taboo that "children under 3 years old are prohibited" in the instructions of Pidotimod preparation.
3. Bupleurum injection
Bupleurum injection has the effect of clearing away heat and relieving exterior syndrome, and is suitable for fever caused by common cold, influenza and malaria. At present, due to adverse reactions such as nausea, vomiting, shortness of breath, dermatitis, anaphylactic shock, etc. Caused by Bupleurum injection, the State Pharmaceutical Administration issued an announcement requesting to change the instruction manual of Bupleurum injection and list it as "forbidden for children".
As the saying goes, "it's a three-point poison." There are many cheap and easy-to-use drugs, but it must be remembered that "rational use of drugs" can give full play to the greatest role of drugs. Drugs should not be eaten indiscriminately, let alone used indiscriminately, so as not to cause adverse reactions and threaten life, health and safety.
#39 Health Super Group #
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